{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:02:57Z","timestamp":1789916577238,"version":"4.0.1"},"reference-count":66,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T00:00:00Z","timestamp":1590451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T00:00:00Z","timestamp":1590451200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T00:00:00Z","timestamp":1590451200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56 AI13646"],"award-info":[{"award-number":["R56 AI13646"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI14110"],"award-info":[{"award-number":["R01 AI14110"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA196266"],"award-info":[{"award-number":["R01 CA196266"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006630","name":"Utah State University","doi-asserted-by":"publisher","award":["Graduate Research and Creative Opportunities grant"],"award-info":[{"award-number":["Graduate Research and Creative Opportunities grant"]}],"id":[{"id":"10.13039\/100006630","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Jun\u00edn virus (JUNV) is one of five New World mammarenaviruses (NWMs) that causes fatal hemorrhagic disease in humans and is the etiological agent of Argentine hemorrhagic fever (AHF). The pathogenesis underlying AHF is poorly understood; however, a prolonged, elevated interferon-\u03b1 (IFN-\u03b1) response is associated with a negative disease outcome. A feature of all NWMs that cause viral hemorrhagic fever is the use of human transferrin receptor 1 (hTfR1) for cellular entry. Here, we show that mice expressing hTfR1 develop a lethal disease course marked by an increase in serum IFN-\u03b1 concentration when challenged with JUNV. Further, we provide evidence that the type I IFN response is central to the development of severe JUNV disease in hTfR1 mice. Our findings identify hTfR1-mediated entry and the type I IFN response as key factors in the pathogenesis of JUNV infection in mice.<\/jats:p>","DOI":"10.7554\/elife.55352","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T08:00:28Z","timestamp":1590480028000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.55352","source":"Crossref","is-referenced-by-count":24,"title":["Type I interferon underlies severe disease associated with Jun\u00edn virus infection in mice"],"prefix":"10.7554","volume":"9","author":[{"given":"Brady T","family":"Hickerson","sequence":"first","affiliation":[{"name":"Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J","family":"Sefing","sequence":"additional","affiliation":[{"name":"Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin W","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud J","family":"Van Wettere","sequence":"additional","affiliation":[{"name":"Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, United States"},{"name":"Utah Veterinary Diagnostic Laboratory, Utah State University, Logan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel L","family":"Penichet","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, United States"},{"name":"Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, United States"},{"name":"UCLA Molecular Biology Institute, Los Angeles, United States"},{"name":"UCLA Jonsson Comprehensive Cancer Center, Los Angeles, United States"},{"name":"UCLA AIDS Institute, Los Angeles, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9113-2575","authenticated-orcid":true,"given":"Brian B","family":"Gowen","sequence":"additional","affiliation":[{"name":"Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2020,5,26]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"10404","DOI":"10.1128\/JVI.00856-11","article-title":"The major determinant of attenuation in mice of the Candid1 vaccine for argentine hemorrhagic fever is located in the G2 glycoprotein transmembrane domain","volume":"85","author":"Albari\u00f1o","year":"2011","journal-title":"Journal of Virology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/jmv.1890210109","article-title":"Protection of jun\u00edn virus-infected marmosets by passive administration of immune serum: association with late neurologic signs","volume":"21","author":"Avila","year":"1987","journal-title":"Journal of Medical Virology"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"8925","DOI":"10.1073\/pnas.1408148111","article-title":"Type I interferon is a therapeutic target for virus-induced lethal vascular damage","volume":"111","author":"Baccala","year":"2014","journal-title":"PNAS"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1093\/infdis\/154.3.478","article-title":"Macrophage maturity and modulation of response to jun\u00edn virus in infected rats","volume":"154","author":"Blejer","year":"1986","journal-title":"Journal of Infectious Diseases"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1159\/000149729","article-title":"Macrophages are involved in age-dependent resistance of rats to Junin virus infection","volume":"27","author":"Blejer","year":"1987","journal-title":"Intervirology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1073\/pnas.73.7.2462","article-title":"Ontogeny of mouse B lymphocytes and inactivation by antigen of early B lymphocytes","volume":"73","author":"Bruyns","year":"1976","journal-title":"PNAS"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1128\/IAI.34.2.323-327.1981","article-title":"Cell-mediated immunity and lymphocyte populations in experimental argentine hemorrhagic fever (Jun\u00edn virus)","volume":"34","author":"Carballal","year":"1981","journal-title":"Infection and Immunity"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S0092-8674(04)00130-8","article-title":"Structure of the human transferrin receptor-transferrin complex","volume":"116","author":"Cheng","year":"2004","journal-title":"Cell"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"664","DOI":"10.2307\/1382739","article-title":"Rodent-Borne hemorrhagic fever viruses: a special risk for mammalogists?","volume":"76","author":"Childs","year":"1995","journal-title":"Journal of Mammalogy"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.mib.2011.07.014","article-title":"Transferrin receptor 1 in the zoonosis and pathogenesis of new world hemorrhagic fever arenaviruses","volume":"14","author":"Choe","year":"2011","journal-title":"Current Opinion in Microbiology"},{"key":"bib11","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13924-6","article-title":"Rational design of universal immunotherapy for TfR1-tropic arenaviruses","volume":"11","author":"Cohen-Dvashi","year":"2020","journal-title":"Nature Communications"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00475","article-title":"Clonal exhaustion as a mechanism to protect against severe immunopathology and death from an overwhelming CD8 T cell response","volume":"4","author":"Cornberg","year":"2013","journal-title":"Frontiers in Immunology"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/jmv.1890180311","article-title":"Role of Calomys musculinus peritoneal macrophages in age-related resistance to Junin virus infection","volume":"18","author":"Coulombi\u00e9","year":"1986","journal-title":"Journal of Medical Virology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1084\/jem.142.5.1078","article-title":"Frequency and avidity of specific antigen-binding cells in developing mice","volume":"142","author":"D'Eustachio","year":"1975","journal-title":"The Journal of Experimental Medicine"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1056\/NEJM197808032990502","article-title":"Argentine hemorrhagic fever\u00a0alterations of the complement system and anti-Junin-virus humoral response","volume":"299","author":"de Bracco","year":"1978","journal-title":"The New England Journal of Medicine"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1097\/MPG.0000000000000206","article-title":"Iron requirements of infants and toddlers","volume":"58","author":"Domell\u00f6f","year":"2014","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"key":"bib17","first-page":"601","article-title":"Age-dependent variations of antibody avidity","volume":"35","author":"Doria","year":"1978","journal-title":"Immunology"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"229","DOI":"10.4269\/ajtmh.1973.22.229","article-title":"Pathology of 12 fatal cases of argentine hemorrhagic fever","volume":"22","author":"Elsner","year":"1973","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1128\/JVI.02102-10","article-title":"Rescue from cloned cDNAs and in vivo characterization of recombinant pathogenic Romero and live-attenuated Candid #1 strains of Junin virus, the causative agent of Argentine hemorrhagic fever disease","volume":"85","author":"Emonet","year":"2011","journal-title":"Journal of Virology"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/BF02122443","article-title":"Current status of the treatment of argentine hemorrhagic fever","volume":"175","author":"Enr\u00eda","year":"1986","journal-title":"Medical Microbiology and Immunology"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.antiviral.2007.10.010","article-title":"Treatment of argentine hemorrhagic fever","volume":"78","author":"Enria","year":"2008","journal-title":"Antiviral Research"},{"key":"bib22","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/793257","article-title":"Brocato RL: animal models for the study of Rodent-Borne hemorrhagic fever viruses: arenaviruses and hantaviruses","volume":"2015","author":"Golden","year":"2015","journal-title":"BioMed Research International"},{"key":"bib23","first-page":"250","article-title":"Laguens RP: lymphatic tissue in argentine hemorrhagic fever\u00a0pathologic features","volume":"104","author":"Gonz\u00e1lez","year":"1980","journal-title":"Archives of Pathology & Laboratory Medicine"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"417","DOI":"10.4269\/ajtmh.1983.32.417","article-title":"Junin virus infection of callithrix jacchus: pathologic features","volume":"32","author":"Gonz\u00e1lez","year":"1983","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"3168","DOI":"10.1128\/AAC.00356-07","article-title":"In vitro and in vivo activities of T-705 against Arenavirus and Bunyavirus infections","volume":"51","author":"Gowen","year":"2007","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"bib26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002614","article-title":"Favipiravir (T-705) inhibits jun\u00edn virus infection and reduces mortality in a guinea pig model of argentine hemorrhagic fever","volume":"7","author":"Gowen","year":"2013","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"4024","DOI":"10.1128\/JVI.06397-11","article-title":"An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses","volume":"86","author":"Helguera","year":"2012","journal-title":"Journal of Virology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1093\/infdis\/166.5.1203","article-title":"Increased tumor necrosis factor-alpha levels in argentine hemorrhagic fever","volume":"166","author":"Heller","year":"1992","journal-title":"Journal of Infectious Diseases"},{"key":"bib29","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01278-19","article-title":"Guinea pig transferrin receptor 1 mediates cellular entry of jun\u00edn virus and other pathogenic new world arenaviruses","volume":"94","author":"Hickerson","year":"2020","journal-title":"Journal of Virology"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.exger.2008.02.007","article-title":"Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy","volume":"43","author":"Hofer","year":"2008","journal-title":"Experimental Gerontology"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1128\/JVI.53.1.75-80.1985","article-title":"Effect of immunosuppression on experimental argentine hemorrhagic fever in guinea pigs","volume":"53","author":"Kenyon","year":"1985","journal-title":"Journal of Virology"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1159\/000150227","article-title":"Aerosol infection of rhesus macaques with Junin virus","volume":"33","author":"Kenyon","year":"1992","journal-title":"Intervirology"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1191\/0960327102ht287oa","article-title":"Critical windows in development of the rodent immune system","volume":"21","author":"Landreth","year":"2002","journal-title":"Human & Experimental Toxicology"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1126\/science.286.5440.779","article-title":"Crystal structure of the ectodomain of human transferrin receptor","volume":"286","author":"Lawrence","year":"1999","journal-title":"Science"},{"key":"bib35","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02061","article-title":"The dual nature of type I and type II interferons","volume":"9","author":"Lee","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1093\/infdis\/149.3.428","article-title":"Endogenous interferon in argentine hemorrhagic fever","volume":"149","author":"Levis","year":"1984","journal-title":"Journal of Infectious Diseases"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1089\/jir.1985.5.383","article-title":"Correlation between endogenous interferon and the clinical evolution of patients with argentine hemorrhagic fever","volume":"5","author":"Levis","year":"1985","journal-title":"Journal of Interferon Research"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"S491","DOI":"10.1177\/15648265070284S402","article-title":"Iron metabolism in infants and children","volume":"28","author":"L\u00f6nnerdal","year":"2007","journal-title":"Food and Nutrition Bulletin"},{"key":"bib39","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2016.32","article-title":"A new transferrin receptor aptamer inhibits new world hemorrhagic fever Mammarenavirus entry","volume":"5","author":"Maier","year":"2016","journal-title":"Molecular Therapy - Nucleic Acids"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"85","DOI":"10.4269\/ajtmh.1999.60.85","article-title":"Proinflammatory cytokines and elastase-alpha-1-antitrypsin in argentine hemorrhagic fever","volume":"60","author":"Marta","year":"1999","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1093\/infdis\/152.1.218","article-title":"Experimental argentine hemorrhagic fever in rhesus macaques: viral strain-dependent clinical response","volume":"152","author":"McKee","year":"1985","journal-title":"Journal of Infectious Diseases"},{"key":"bib42","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09098-w","article-title":"Cryo-EM structure of the human ferritin-transferrin receptor 1 complex","volume":"10","author":"Montemiglio","year":"2019","journal-title":"Nature Communications"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"E7814","DOI":"10.1073\/pnas.1804674115","article-title":"Lymphocytic choriomeningitis virus clone 13 infection causes either persistence or acute death dependent on IFN-1, cytotoxic T lymphocytes (CTLs), and host genetics","volume":"115","author":"Oldstone","year":"2018","journal-title":"PNAS"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1146\/annurev-pathol-020712-164041","article-title":"Pathogenesis of the viral hemorrhagic fevers","volume":"8","author":"Paessler","year":"2013","journal-title":"Annual Review of Pathology: Mechanisms of Disease"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/70938","article-title":"Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway","volume":"5","author":"Puglielli","year":"1999","journal-title":"Nature Medicine"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature05539","article-title":"Transferrin receptor 1 is a cellular receptor for new world haemorrhagic fever arenaviruses","volume":"446","author":"Radoshitzky","year":"2007","journal-title":"Nature"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"2664","DOI":"10.1073\/pnas.0709254105","article-title":"Receptor determinants of zoonotic transmission of new world hemorrhagic fever arenaviruses","volume":"105","author":"Radoshitzky","year":"2008","journal-title":"PNAS"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","article-title":"A simple method of estimating fifty percent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"American Journal of Hygiene"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/978-3-642-56029-3_2","article-title":"Mammalian reservoirs of arenaviruses","volume":"262","author":"Salazar-Bravo","year":"2002","journal-title":"Current Topics in Microbiology and Immunology"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1146\/annurev-virology-101416-042001","article-title":"New world arenavirus biology","volume":"4","author":"Sarute","year":"2017","journal-title":"Annual Review of Virology"},{"key":"bib51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003073","article-title":"Lymphocytic choriomeningitis virus infection in FVB mouse produces hemorrhagic disease","volume":"8","author":"Schnell","year":"2012","journal-title":"PLOS Pathogens"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-\u03b3: an overview of signals, mechanisms and functions","volume":"75","author":"Schroder","year":"2004","journal-title":"Journal of Leukocyte Biology"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1002\/hep.1840110313","article-title":"Transferrin receptor expression in rat liver: immunohistochemical and biochemical analysis of the effect of age and iron storage","volume":"11","author":"Sciot","year":"1990","journal-title":"Hepatology"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1146\/annurev.micro.55.1.255","article-title":"Viruses and interferons","volume":"55","author":"Sen","year":"2001","journal-title":"Annual Review of Microbiology"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"5949","DOI":"10.1128\/JVI.00104-15","article-title":"The glycoprotein precursor gene of Junin virus determines the virulence of the Romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever","volume":"89","author":"Seregin","year":"2015","journal-title":"Journal of Virology"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.4049\/jimmunol.1402794","article-title":"Interfering with immunity: detrimental role of type I IFNs during infection","volume":"194","author":"Stifter","year":"2015","journal-title":"The Journal of Immunology"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1126\/science.1235214","article-title":"Persistent LCMV infection is controlled by blockade of type I interferon signaling","volume":"340","author":"Teijaro","year":"2013","journal-title":"Science"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/nature10624","article-title":"Natural killer cells act as rheostats modulating antiviral T cells","volume":"481","author":"Waggoner","year":"2012","journal-title":"Nature"},{"key":"bib59","first-page":"507","article-title":"Experimental biology and pathogenesis of junin virus infection in animals and man","volume":"52","author":"Weissenbacher","year":"1975","journal-title":"Bulletin of the World Health Organization"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1159\/000149059","article-title":"Argentine hemorrhagic fever: a primate model","volume":"11","author":"Weissenbacher","year":"1979","journal-title":"Intervirology"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1126\/science.1235208","article-title":"Blockade of chronic type I interferon signaling to control persistent LCMV infection","volume":"340","author":"Wilson","year":"2013","journal-title":"Science"},{"key":"bib62","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01682-17","article-title":"Epistastic Interactions within the Jun\u00edn Virus Envelope Glycoprotein Complex Provide an Evolutionary Barrier to Reversion in the Live-Attenuated Candid#1 Vaccine","volume":"92","author":"York","year":"2018","journal-title":"Journal of Virology"},{"key":"bib63","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009835","article-title":"Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates","volume":"6","author":"Yu","year":"2014","journal-title":"Science Translational Medicine"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"275","DOI":"10.4269\/ajtmh.2008.79.275","article-title":"Pathogenesis of XJ and Romero strains of Junin virus in two strains of guinea pigs","volume":"79","author":"Yun","year":"2008","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"4458","DOI":"10.1073\/pnas.1600996113","article-title":"Monoclonal antibody therapy for Junin virus infection","volume":"113","author":"Zeitlin","year":"2016","journal-title":"PNAS"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"9418","DOI":"10.1128\/JVI.01112-14","article-title":"Human and host species transferrin receptor 1 use by north american arenaviruses","volume":"88","author":"Zong","year":"2014","journal-title":"Journal of Virology"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/55352\/elife-55352-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/55352\/elife-55352-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/55352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:05:05Z","timestamp":1697058305000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/55352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,26]]},"references-count":66,"alternative-id":["10.7554\/eLife.55352"],"URL":"https:\/\/doi.org\/10.7554\/elife.55352","archive":["CLOCKSS"],"relation":{"has-review":[{"id-type":"doi","id":"10.7554\/eLife.55352.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.55352.sa2","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,26]]},"article-number":"e55352"}}