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A limited amount of stem cell-driven neurogenesis persists in postnatal life and is reduced in large-brained species. Another source of immature neurons in adult brains is cortical layer II. These cortical immature neurons (cINs) retain developmentally undifferentiated states in adulthood, though they are generated before birth. Here, the occurrence, distribution and cellular features of cINs were systematically studied in 12 diverse mammalian species spanning from small-lissencephalic to large-gyrencephalic brains. In spite of well-preserved morphological and molecular features, the distribution of cINs was highly heterogeneous, particularly in neocortex. While virtually absent in rodents, they are present in the entire neocortex of many other species and their linear density in cortical layer II generally increased with brain size. These findings suggest an evolutionary developmental mechanism for plasticity that varies among mammalian species, granting a reservoir of young cells for the cerebral cortex.<\/jats:p>","DOI":"10.7554\/elife.55456","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T20:00:29Z","timestamp":1595275229000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.55456","source":"Crossref","is-referenced-by-count":63,"title":["Phylogenetic variation in cortical layer II immature neuron reservoir of mammals"],"prefix":"10.7554","volume":"9","author":[{"given":"Chiara","family":"La Rosa","sequence":"first","affiliation":[{"name":"Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Italy"},{"name":"Department of Veterinary Sciences, University of Turin, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Cavallo","sequence":"additional","affiliation":[{"name":"Neuroscience Institute Cavalieri Ottolenghi 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