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Many drivers have been identified, but their molecular mechanisms are largely unknown. The\n                    <jats:italic>wtf4<\/jats:italic>\n                    gene is a meiotic driver in\n                    <jats:italic>Schizosaccharomyces pombe<\/jats:italic>\n                    that uses a poison-antidote mechanism to selectively kill meiotic products (spores) that do not inherit\n                    <jats:italic>wtf4<\/jats:italic>\n                    . Here, we show that the Wtf4 proteins can function outside of gametogenesis and in a distantly related species,\n                    <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    . The Wtf4\n                    <jats:sup>poison<\/jats:sup>\n                    protein forms dispersed, toxic aggregates. The Wtf4\n                    <jats:sup>antidote<\/jats:sup>\n                    can co-assemble with the Wtf4\n                    <jats:sup>poison<\/jats:sup>\n                    and promote its trafficking to vacuoles. We show that neutralization of the Wtf4\n                    <jats:sup>poison<\/jats:sup>\n                    requires both co-assembly with the Wtf4\n                    <jats:sup>antidote<\/jats:sup>\n                    and aggregate trafficking, as mutations that disrupt either of these processes result in cell death in the presence of the Wtf4 proteins. This work reveals that\n                    <jats:italic>wtf<\/jats:italic>\n                    parasites can exploit protein aggregate management pathways to selectively destroy spores.\n                  <\/jats:p>","DOI":"10.7554\/elife.55694","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T07:02:01Z","timestamp":1603782121000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.55694","source":"Crossref","is-referenced-by-count":40,"title":["The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death"],"prefix":"10.7554","volume":"9","author":[{"given":"Nicole L","family":"Nuckolls","sequence":"first","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony C","family":"Mok","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, United States"},{"name":"University of Missouri-Kansas City, Kansas City, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J","family":"Lange","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexi","family":"Yi","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejbir S","family":"Kandola","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, United States"},{"name":"Open University, Milton Keynes, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M","family":"Hunn","sequence":"additional","affiliation":[{"name":"Stowers Institute for Medical Research, Kansas City, United 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