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We built a biochemically detailed model of post-synaptic plasticity describing CaMKII, PKA, and PKC pathways and their contribution to synaptic potentiation or depression. We developed a statistical AMPA-receptor-tetramer model, which permits the estimation of the AMPA-receptor-mediated maximal synaptic conductance based on numbers of GluR1s and GluR2s predicted by the biochemical signalling model. We show that our model reproduces neuromodulator-gated spike-timing-dependent plasticity as observed in the visual cortex and can be fit to data from many cortical areas, uncovering the biochemical contributions of the pathways pinpointed by the underlying experimental studies. Our model explains the dependence of different forms of plasticity on the availability of different proteins and can be used for the study of mental disorder-associated impairments of cortical plasticity.<\/jats:p>","DOI":"10.7554\/elife.55714","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T08:00:25Z","timestamp":1596096025000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.55714","source":"Crossref","is-referenced-by-count":54,"title":["A unified computational model for cortical post-synaptic plasticity"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7082-2507","authenticated-orcid":true,"given":"Tuomo","family":"M\u00e4ki-Marttunen","sequence":"first","affiliation":[{"name":"Simula Research Laboratory, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolangelo","family":"Iannella","sequence":"additional","affiliation":[{"name":"Department of Biosciences, University of Oslo, 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