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Using forward and reverse genetics in zebrafish, we show that disrupting the glycolytic gene phosphoglycerate kinase-1 (pgk1) impairs Fgf-dependent development of hair cells and neurons in the otic vesicle and other neurons in the CNS\/PNS. Fgf-MAPK signaling underperforms in pgk1- \/ - mutants even when Fgf is transiently overexpressed. Wild-type embryos treated with drugs that block synthesis or secretion of lactate mimic the pgk1- \/ - phenotype, whereas pgk1- \/ - mutants are rescued by treatment with exogenous lactate. Lactate treatment of wild-type embryos elevates expression of Etv5b\/Erm even when Fgf signaling is blocked. However, lactate\u2019s ability to stimulate neurogenesis is reversed by blocking MAPK. Thus, lactate raises basal levels of MAPK and Etv5b (a critical effector of the Fgf pathway), rendering cells more responsive to dynamic changes in Fgf signaling required by many developing tissues.<\/jats:p>","DOI":"10.7554\/elife.56301","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T13:17:35Z","timestamp":1587993455000},"source":"Crossref","is-referenced-by-count":26,"title":["The Warburg Effect and lactate signaling augment Fgf-MAPK to promote sensory-neural development in the otic vesicle"],"prefix":"10.7554","volume":"9","author":[{"given":"Husniye","family":"Kantarci","sequence":"first","affiliation":[{"name":"Biology Department, Texas A&M University, College Station, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3105-252X","authenticated-orcid":true,"given":"Yunzi","family":"Gou","sequence":"additional","affiliation":[{"name":"Biology Department, Texas A&M University, College 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