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However, the role of these pathways in different tissues is incompletely understood, an issue particularly relevant to the CMVs which have broad tissue tropisms. Herein, we contrasted anti-viral effects of MyD88 versus STING in distinct cell types that are infected with murine CMV (MCMV). Bone marrow chimeras revealed STING-mediated MCMV control in hematological cells, similar to MyD88. However, unlike MyD88, STING also contributed to viral control in non-hematological, stromal cells. Infected splenic stromal cells produced IFN-I in a cGAS-STING-dependent and MyD88-independent manner, while we confirmed plasmacytoid dendritic cell IFN-I had inverse requirements. MCMV-induced natural killer cytotoxicity was dependent on MyD88 and STING. Thus, MyD88 and STING contribute to MCMV control in distinct cell types that initiate downstream immune responses.<\/jats:p>","DOI":"10.7554\/elife.56882","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T08:01:13Z","timestamp":1596009673000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.56882","source":"Crossref","is-referenced-by-count":23,"title":["Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5379-3556","authenticated-orcid":true,"given":"Sytse J","family":"Piersma","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Poursine-Laurent","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen N","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijal A","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, United 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