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It has been hypothesized that maternal vaginal microbiota is an important initial seeding source and therefore might have lifelong effects on disease risk. To understand maternal vaginal microbiota\u2019s role in seeding the child\u2019s microbiota and the extent of delivery mode-dependent transmission, we studied 665 mother\u2013child dyads from the COPSAC\n                    <jats:sub>2010<\/jats:sub>\n                    cohort. The maternal vaginal microbiota was evaluated twice in the third trimester and compared with the children\u2019s fecal (at 1 week, 1 month, and 1 year of age) and airway microbiota (at 1 week, 1 month, and 3 months). Based on the concept of weighted transfer ratios (WTRs), we have identified bacterial orders for which the WTR displays patterns indicate persistent or transient transfer from the maternal vaginal microbiome, as well as orders that are shared at later time points independent of delivery mode, indicating a common reservoir.\n                  <\/jats:p>","DOI":"10.7554\/elife.57051","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T10:00:23Z","timestamp":1610704823000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.57051","source":"Crossref","is-referenced-by-count":49,"title":["Modeling transfer of vaginal microbiota from mother to infant in early life"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-7533","authenticated-orcid":true,"given":"Martin Steen","family":"Mortensen","sequence":"first","affiliation":[{"name":"Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, 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