{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:05:50Z","timestamp":1792447550983,"version":"4.5.0"},"reference-count":111,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL092206"],"award-info":[{"award-number":["HL092206"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003043","name":"EMBO","doi-asserted-by":"publisher","award":["Long-Term Fellowship ALTF 751-2014"],"award-info":[{"award-number":["Long-Term Fellowship ALTF 751-2014"]}],"id":[{"id":"10.13039\/501100003043","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["F31 AG044948"],"award-info":[{"award-number":["F31 AG044948"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    One life-threatening outcome of cardiovascular disease is myocardial infarction, where cardiomyocytes are deprived of oxygen. To study inter-individual differences in response to hypoxia, we established an in vitro model of induced pluripotent stem cell-derived cardiomyocytes from 15 individuals. We measured gene expression levels, chromatin accessibility, and methylation levels in four culturing conditions that correspond to normoxia, hypoxia, and short- or long-term re-oxygenation. We characterized thousands of gene regulatory changes as the cells transition between conditions. Using available genotypes, we identified 1,573 genes with a\n                    <jats:italic>cis<\/jats:italic>\n                    expression quantitative locus (eQTL) in at least one condition, as well as 367 dynamic eQTLs, which are classified as eQTLs in at least one, but not in all conditions. A subset of genes with dynamic eQTLs is associated with complex traits and disease. Our data demonstrate how dynamic genetic effects on gene expression, which are likely relevant for disease, can be uncovered under stress.\n                  <\/jats:p>","DOI":"10.7554\/elife.57345","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T08:00:22Z","timestamp":1612771222000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.57345","source":"Crossref","is-referenced-by-count":60,"title":["Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1485-320X","authenticated-orcid":true,"given":"Michelle C","family":"Ward","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Chicago, Chicago, United States"},{"name":"Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2604-3247","authenticated-orcid":true,"given":"Nicholas E","family":"Banovich","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Chicago, Chicago, United States"},{"name":"Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4636-9255","authenticated-orcid":true,"given":"Abhishek","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Chicago, Chicago, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Chicago, Chicago, United States"},{"name":"Department of Statistics, University of Chicago, 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