{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:22:07Z","timestamp":1777692127799,"version":"3.51.4"},"reference-count":55,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["4183-00258B"],"award-info":[{"award-number":["4183-00258B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["7025-00050A"],"award-info":[{"award-number":["7025-00050A"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R93-A8859"],"award-info":[{"award-number":["R93-A8859"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R287-2018-735"],"award-info":[{"award-number":["R287-2018-735"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MEMBRANES Research Center"}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Acid-base conditions modify artery tone and tissue perfusion but the involved vascular-sensing mechanisms and disease consequences remain unclear. We experimentally investigated transgenic mice and performed genetic studies in a UK-based human cohort. We show that endothelial cells express the putative HCO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>\u2013<\/jats:sup>\n                    -sensor receptor-type tyrosine-protein phosphatase RPTP\u03b3, which enhances endothelial intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -responses in resistance arteries and facilitates endothelium-dependent vasorelaxation only when CO\n                    <jats:sub>2<\/jats:sub>\n                    \/HCO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>\u2013<\/jats:sup>\n                    is present. Consistent with waning RPTP\u03b3-dependent vasorelaxation at low [HCO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>\u2013<\/jats:sup>\n                    ], RPTP\u03b3 limits increases in cerebral perfusion during neuronal activity and augments decreases in cerebral perfusion during hyperventilation. RPTP\u03b3 does not influence resting blood pressure but amplifies hyperventilation-induced blood pressure elevations. Loss-of-function variants in\n                    <jats:italic>PTPRG<\/jats:italic>\n                    , encoding RPTP\u03b3, are associated with increased risk of cerebral infarction, heart attack, and reduced cardiac ejection fraction. We conclude that\n                    <jats:italic>PTPRG<\/jats:italic>\n                    is an ischemia susceptibility locus; and RPTP\u03b3-dependent sensing of HCO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>\u2013<\/jats:sup>\n                    adjusts endothelium-mediated vasorelaxation, microvascular perfusion, and blood pressure during acid-base disturbances and altered tissue metabolism.\n                  <\/jats:p>","DOI":"10.7554\/elife.57553","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T08:01:04Z","timestamp":1600675264000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.57553","source":"Crossref","is-referenced-by-count":20,"title":["PTPRG is an ischemia risk locus essential for HCO3\u2013-dependent regulation of endothelial function and tissue perfusion"],"prefix":"10.7554","volume":"9","author":[{"given":"Kristoffer B","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Staehr","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4347-8656","authenticated-orcid":true,"given":"Palle D","family":"Rohde","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casper","family":"Homilius","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukhan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"Nyegaard","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3303-1095","authenticated-orcid":true,"given":"Vladimir V","family":"Matchkov","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5078-9279","authenticated-orcid":true,"given":"Ebbe","family":"Boedtkjer","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4374","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1113\/jphysiol.1988.sp017211","article-title":"Intracellular pH regulation in resting and contracting segments of rat mesenteric resistance vessels","volume":"402","author":"Aalkjaer","year":"1988","journal-title":"The Journal of Physiology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1113\/jphysiol.1991.sp018539","article-title":"Chloride and bicarbonate transport in rat resistance arteries","volume":"436","author":"Aalkjaer","year":"1991","journal-title":"The Journal of Physiology"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/j.1476-5381.1980.tb07892.x","article-title":"Adverse effects of artificial buffers on contractile responses of arterial and venous smooth muscle","volume":"69","author":"Altura","year":"1980","journal-title":"British Journal of Pharmacology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/neuro.01.001.2008","article-title":"Layer, column and cell-type specific genetic manipulation in mouse barrel cortex","volume":"2","author":"Aronoff","year":"2008","journal-title":"Frontiers in Neuroscience"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s00424-013-1323-z","article-title":"Acidosis prevents and alkalosis augments endothelium-dependent contractions in mouse arteries","volume":"466","author":"Baretella","year":"2014","journal-title":"Pfl\u00fcgers Archiv - European Journal of Physiology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1128\/MCB.13.3.1497","article-title":"Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP\u03b3 defines a new subfamily of receptor tyrosine phosphatases","volume":"13","author":"Barnea","year":"1993","journal-title":"Molecular and Cellular Biology"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.cell.2008.11.038","article-title":"Large-scale structural analysis of the classical human protein tyrosine phosphatome","volume":"136","author":"Barr","year":"2009","journal-title":"Cell"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"C932","DOI":"10.1152\/ajpcell.1993.264.4.C932","article-title":"Cytosolic free calcium regulation in response to acute changes in intracellular pH in vascular smooth muscle","volume":"264","author":"Batlle","year":"1993","journal-title":"American Journal of Physiology-Cell Physiology"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1161\/01.RES.0000204750.04971.76","article-title":"NBCn1 (slc4a7) mediates the Na+-dependent bicarbonate transport important for regulation of intracellular pH in mouse vascular smooth muscle cells","volume":"98","author":"Boedtkjer","year":"2006","journal-title":"Circulation Research"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"C591","DOI":"10.1152\/ajpcell.00281.2007","article-title":"Antibody-independent localization of the electroneutral Na+-HCO3\u2013\u00a0cotransporter NBCn1 (slc4a7) in mice","volume":"294","author":"Boedtkjer","year":"2008","journal-title":"American Journal of Physiology-Cell Physiology"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1161\/CIRCULATIONAHA.110.015974","article-title":"Disruption of Na+,HCO3\u207b cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca2+ sensitivity, and hypertension development in mice","volume":"124","author":"Boedtkjer","year":"2011","journal-title":"Circulation"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1113\/jphysiol.2011.227132","article-title":"NHE1 knockout reduces blood pressure and arterial media\/lumen ratio with no effect on resting pHi\u00a0in the vascular wall","volume":"590","author":"Boedtkjer","year":"2012","journal-title":"The Journal of Physiology"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1113\/jphysiol.2012.247478","article-title":"Endothelial alkalinisation inhibits gap junction communication and endothelium-derived hyperpolarisations in mouse mesenteric arteries","volume":"591","author":"Boedtkjer","year":"2013","journal-title":"The Journal of Physiology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1152\/physiol.00001.2016","article-title":"Negative news: Cl\u2013\u00a0and HCO3\u2013\u00a0in the vascular wall","volume":"31","author":"Boedtkjer","year":"2016","journal-title":"Physiology"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1093\/cvr\/cvw079","article-title":"Na+, HCO3\u2013-cotransporter NBCn1 increases pHi gradients, Filopodia, and migration of smooth muscle cells and promotes arterial remodelling","volume":"111","author":"Boedtkjer","year":"2016","journal-title":"Cardiovascular Research"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1177\/0271678X15610787","article-title":"Extracellular HCO3\u2013\u00a0is sensed by mouse cerebral arteries: regulation of tone by receptor protein tyrosine phosphatase \u03b3","volume":"36","author":"Boedtkjer","year":"2016","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1177\/0271678X17733868","article-title":"Acid-base regulation and sensing: accelerators and brakes in metabolic regulation of cerebrovascular tone","volume":"38","author":"Boedtkjer","year":"2018","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"H247","DOI":"10.1152\/ajpheart.00725.2008","article-title":"Insulin inhibits Na+\/H+ exchange in vascular smooth muscle and endothelial cells in situ: involvement of H2O2 and tyrosine phosphatase SHP-2","volume":"296","author":"Boedtkjer","year":"2009","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1159\/000341235","article-title":"Intracellular pH in the resistance vasculature: regulation and functional implications","volume":"49","author":"Boedtkjer","year":"2012","journal-title":"Journal of Vascular Research"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.tcm.2012.09.001","article-title":"Acid\u2013base transporters modulate cell migration, growth and proliferation: Implications for structure development and remodeling of resistance arteries?","volume":"23","author":"Boedtkjer","year":"2013","journal-title":"Trends in Cardiovascular Medicine"},{"key":"bib21","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00388","article-title":"Disturbed acid-base transport: an emerging cause of hypertension","volume":"4","author":"Boedtkjer","year":"2013","journal-title":"Frontiers in Physiology"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jneumeth.2015.02.024","article-title":"Characterisation and comparison of temporal release profiles of nitric oxide generating donors","volume":"245","author":"Bradley","year":"2015","journal-title":"Journal of Neuroscience Methods"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.vph.2005.07.009","article-title":"Protease-activated receptor-2 (PAR2) in cardiovascular system","volume":"43","author":"Bucci","year":"2005","journal-title":"Vascular Pharmacology"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1161\/STROKEAHA.115.009044","article-title":"Meta-Analysis of Genome-Wide association studies identifies genetic risk factors for stroke in african americans","volume":"46","author":"Carty","year":"2015","journal-title":"Stroke"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1126\/science.289.5479.625","article-title":"Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor","volume":"289","author":"Chen","year":"2000","journal-title":"Science"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1177\/002215549804600204","article-title":"Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues","volume":"46","author":"D'Andrea","year":"1998","journal-title":"Journal of Histochemistry & Cytochemistry"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"8146","DOI":"10.1074\/jbc.M113.455386","article-title":"Splice cassette II of Na+,HCO3- cotransporter NBCn1 (slc4a7) interacts with calcineurin A: implications for transporter activity and intracellular pH control during rat artery contractions","volume":"288","author":"Danielsen","year":"2013","journal-title":"The Journal of Biological Chemistry"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1161\/01.RES.74.6.1220","article-title":"Intracellular alkalinization induced by bradykinin sustains activation of the constitutive nitric oxide synthase in endothelial cells","volume":"74","author":"Fleming","year":"1994","journal-title":"Circulation Research"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1113\/jphysiol.1880.sp000083","article-title":"On the tonicity of the heart and blood vessels","volume":"3","author":"Gaskell","year":"1880","journal-title":"The Journal of Physiology"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.cell.2020.01.015","article-title":"Single-Cell transcriptome atlas of murine endothelial cells","volume":"180","author":"Kalucka","year":"2020","journal-title":"Cell"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"5106","DOI":"10.1128\/MCB.00101-06","article-title":"Receptor protein tyrosine phosphatase\u00a0\u03b3\u00a0is a marker for pyramidal cells and sensory neurons in the nervous system and is not necessary for normal development","volume":"26","author":"Lamprianou","year":"2006","journal-title":"Molecular and Cellular Biology"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3109\/00365516809167060","article-title":"Brain extracellular pH: the main factor controlling cerebral blood flow","volume":"22","author":"Lassen","year":"1968","journal-title":"Scandinavian Journal of Clinical and Laboratory Investigation"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2013\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nature01905","article-title":"Proton-sensing G-protein-coupled receptors","volume":"425","author":"Ludwig","year":"2003","journal-title":"Nature"},{"key":"bib36","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-0974-4","article-title":"The ensembl variant effect predictor","volume":"17","author":"McLaren","year":"2016","journal-title":"Genome Biology"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1161\/01.STR.0000169929.66497.73","article-title":"Possible role for K+ in endothelium-derived hyperpolarizing factor-linked dilatation in rat middle cerebral artery","volume":"36","author":"McNeish","year":"2005","journal-title":"Stroke"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1161\/01.RES.41.1.19","article-title":"Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats","volume":"41","author":"Mulvany","year":"1977","journal-title":"Circulation Research"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1177\/0271678X17699224","article-title":"Carbonic anhydrase inhibitors modify intracellular pH transients and contractions of rat middle cerebral arteries during CO2\/HCO3-\u2013\u00a0fluctuations","volume":"38","author":"Rasmussen","year":"2018","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"key":"bib40","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06159-4","article-title":"Functional equivalence of genome sequencing analysis pipelines enables harmonized variant calling across human genetics projects","volume":"9","author":"Regier","year":"2018","journal-title":"Nature Communications"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"2614","DOI":"10.1093\/bioinformatics\/btz955","article-title":"Qgg: an R package for large-scale quantitative genetic analyses","volume":"36","author":"Rohde","year":"2020","journal-title":"Bioinformatics"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1152\/physrev.1981.61.2.296","article-title":"Intracellular pH","volume":"61","author":"Roos","year":"1981","journal-title":"Physiological Reviews"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1159\/000051027","article-title":"Protons inhibit the BKCa\u00a0channel of rat small artery smooth muscle cells","volume":"38","author":"Schubert","year":"2001","journal-title":"Journal of Vascular Research"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1113\/jphysiol.2001.013268","article-title":"Facilitation of intracellular H+\u00a0ion mobility by CO2\/HCO3\u2013\u00a0in rabbit ventricular myocytes is regulated by carbonic anhydrase","volume":"541","author":"Spitzer","year":"2002","journal-title":"The Journal of Physiology"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s10554-017-1225-9","article-title":"Fully-automated left ventricular mass and volume MRI analysis in the UK Biobank population cohort: evaluation of initial results","volume":"34","author":"Suinesiaputra","year":"2018","journal-title":"The International Journal of Cardiovascular Imaging"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/jcbfm.2013.192","article-title":"Intracellular acidification alters myogenic responsiveness and vasomotion of mouse middle cerebral arteries","volume":"34","author":"Thomsen","year":"2014","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"key":"bib47","doi-asserted-by":"publisher","DOI":"10.1101\/572347","article-title":"Whole exome sequencing and characterization of coding variation in 49,960 individuals in the UK biobank","volume-title":"bioRxiv","author":"Van Hout","year":"2019"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/nature25739","article-title":"A molecular atlas of cell types and zonation in the brain vasculature","volume":"554","author":"Vanlandewijck","year":"2018","journal-title":"Nature"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"H245","DOI":"10.1152\/ajpheart.00368.2018","article-title":"Enhanced nitric oxide signaling amplifies vasorelaxation of human Colon cancer feed arteries","volume":"316","author":"Voss","year":"2019","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"bib50","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12040891","article-title":"Targeting the acidic tumor microenvironment: unexpected\u00a0pro-neoplastic effects of oral NaHCO3\u00a0therapy in murine breast tissue","volume":"12","author":"Voss","year":"2020","journal-title":"Cancers"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/BF00586483","article-title":"Micropuncture evaluation of the importance of perivascular pH for the arteriolar diameter on the brain surface","volume":"316","author":"Wahl","year":"1970","journal-title":"Pfl\u00fcgers Archiv European Journal of Physiology"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.tins.2006.06.014","article-title":"Acid-sensing ion channels: advances, questions and therapeutic opportunities","volume":"29","author":"Wemmie","year":"2006","journal-title":"Trends in Neurosciences"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1073\/pnas.1907467117","article-title":"Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice","volume":"117","author":"Wenzel","year":"2020","journal-title":"PNAS"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/374636a0","article-title":"Out-of-equilibrium CO2\/HCO3\u2013\u00a0solutions and their use in characterizing a new K\/HCO3 cotransporter","volume":"374","author":"Zhao","year":"1995","journal-title":"Nature"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.1681\/ASN.2015040439","article-title":"Role of receptor protein tyrosine phosphatase \u03b3 in sensing extracellular CO2 and HCO3\u2013","volume":"27","author":"Zhou","year":"2016","journal-title":"Journal of the American Society of Nephrology : JASN"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/57553\/elife-57553-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/57553\/elife-57553-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/57553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:09:34Z","timestamp":1697058574000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/57553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,21]]},"references-count":55,"alternative-id":["10.7554\/eLife.57553"],"URL":"https:\/\/doi.org\/10.7554\/elife.57553","archive":["CLOCKSS"],"relation":{"has-review":[{"id-type":"doi","id":"10.7554\/eLife.57553.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.57553.sa2","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,21]]},"article-number":"e57553"}}