{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:06:36Z","timestamp":1788955596913,"version":"build-2803163510"},"reference-count":72,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DE027568"],"award-info":[{"award-number":["R01DE027568"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL14058"],"award-info":[{"award-number":["R01HL14058"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DE027538"],"award-info":[{"award-number":["R01DE027538"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18PRE34050063"],"award-info":[{"award-number":["18PRE34050063"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99DE028592"],"award-info":[{"award-number":["K99DE028592"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    During gastrulation, neural crest cells are specified at the neural plate border, as characterized by\n                    <jats:italic>Pax7<\/jats:italic>\n                    expression. Using single-cell RNA sequencing coupled with high-resolution\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization to identify novel transcriptional regulators, we show that chromatin remodeler\n                    <jats:italic>Hmga1<\/jats:italic>\n                    is highly expressed prior to specification and maintained in migrating chick neural crest cells. Temporally controlled CRISPR-Cas9-mediated knockouts uncovered two distinct functions of\n                    <jats:italic>Hmga1<\/jats:italic>\n                    in neural crest development. At the neural plate border,\n                    <jats:italic>Hmga1<\/jats:italic>\n                    regulates Pax7-dependent neural crest lineage specification. At premigratory stages, a second role manifests where\n                    <jats:italic>Hmga1<\/jats:italic>\n                    loss reduces cranial crest emigration from the dorsal neural tube independent of\n                    <jats:italic>Pax7.<\/jats:italic>\n                    Interestingly, this is rescued by stabilized \u00df-catenin, thus implicating\n                    <jats:italic>Hmga1<\/jats:italic>\n                    as a canonical Wnt activator. Together, our results show that\n                    <jats:italic>Hmga1<\/jats:italic>\n                    functions in a bimodal manner during neural crest development to regulate specification at the neural plate border, and subsequent emigration from the neural tube via canonical Wnt signaling.\n                  <\/jats:p>","DOI":"10.7554\/elife.57779","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T08:00:17Z","timestamp":1600848017000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.57779","source":"Crossref","is-referenced-by-count":26,"title":["Bimodal function of chromatin remodeler Hmga1 in neural crest induction and Wnt-dependent emigration"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4081-4338","authenticated-orcid":true,"given":"Shashank","family":"Gandhi","sequence":"first","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4316-0333","authenticated-orcid":true,"given":"Erica J","family":"Hutchins","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystyna","family":"Maruszko","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong H","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Thomson","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4274-1862","authenticated-orcid":true,"given":"Marianne E","family":"Bronner","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"bib1","first-page":"3117","article-title":"Pancreatic duct cell carcinomas express high levels of high mobility group I(Y) proteins","volume":"60","author":"Abe","year":"2000","journal-title":"Cancer Research"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/nature08733","article-title":"CHD7 cooperates with PBAF to control multipotent neural crest formation","volume":"463","author":"Bajpai","year":"2010","journal-title":"Nature"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/nature04684","article-title":"Specification of the neural crest occurs during gastrulation and requires Pax7","volume":"441","author":"Basch","year":"2006","journal-title":"Nature"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1096\/fj.02-0977fje","article-title":"Loss of Hmga1 gene function affects embryonic stem cell lympho-hematopoietic differentiation","volume":"17","author":"Battista","year":"2003","journal-title":"The FASEB Journal"},{"key":"bib5","article-title":"Dynamic thresholding of Grey-Level images","author":"Bernsen","year":"1986","unstructured":"Bernsen J. 1986. 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