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Here, we describe a novel population of lateral septum neurons expressing neurotensin (LS\n                    <jats:sup>Nts<\/jats:sup>\n                    ) in mice that are selectively tuned to specific types of stress. LS\n                    <jats:sup>Nts<\/jats:sup>\n                    neurons increase their activity during active escape, responding to stress when flight is a viable option, but not when associated with freezing or immobility. Chemogenetic activation of LS\n                    <jats:sup>Nts<\/jats:sup>\n                    neurons decreases food intake and body weight, without altering locomotion and anxiety. LS\n                    <jats:sup>Nts<\/jats:sup>\n                    neurons co-express several molecules including Glp1r (glucagon-like peptide one receptor) and manipulations of Glp1r signaling in the LS recapitulates the behavioral effects of LS\n                    <jats:sup>Nts<\/jats:sup>\n                    activation. Activation of LS\n                    <jats:sup>Nts<\/jats:sup>\n                    terminals in the lateral hypothalamus (LH) also decreases food intake. These results show that LS\n                    <jats:sup>Nts<\/jats:sup>\n                    neurons are selectively tuned to active escape stress and can reduce food consumption via effects on hypothalamic pathways.\n                  <\/jats:p>","DOI":"10.7554\/elife.58894","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T07:00:19Z","timestamp":1599462019000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.58894","source":"Crossref","is-referenced-by-count":99,"title":["A limbic circuit selectively links active escape to food suppression"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3149-7270","authenticated-orcid":true,"given":"Estefania P","family":"Azevedo","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Genetics, The Rockefeller University, New York, United 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