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It remains unclear to what extent pituitary stem cells (PSCs), which uniquely express SOX2, contribute to pituitary growth and renewal. Moreover, neither the signals that drive proliferation nor their sources have been elucidated. We have used genetic approaches in the mouse, showing that the WNT pathway is essential for proliferation of all lineages in the gland. We reveal that SOX2\n                    <jats:sup>+<\/jats:sup>\n                    stem cells are a key source of WNT ligands. By blocking secretion of WNTs from SOX2\n                    <jats:sup>+<\/jats:sup>\n                    PSCs in vivo, we demonstrate that proliferation of neighbouring committed progenitor cells declines, demonstrating that progenitor multiplication depends on the paracrine WNT secretion from SOX2\n                    <jats:sup>+<\/jats:sup>\n                    PSCs. Our results indicate that stem cells can hold additional roles in tissue expansion and homeostasis, acting as paracrine signalling centres to coordinate the proliferation of neighbouring cells.\n                  <\/jats:p>","DOI":"10.7554\/elife.59142","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T08:07:56Z","timestamp":1609834076000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.59142","source":"Crossref","is-referenced-by-count":44,"title":["Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells"],"prefix":"10.7554","volume":"10","author":[{"given":"John P","family":"Russell","sequence":"first","affiliation":[{"name":"Centre for Craniofacial and Regenerative Biology, King\u2019s College London, London, United 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9857-7577","authenticated-orcid":true,"given":"Val","family":"Yianni","sequence":"additional","affiliation":[{"name":"Centre for Craniofacial and Regenerative Biology, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine","family":"Kemkem","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics (IGF), University of Montpellier, CNRS, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Wang","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Stanford University School of Medicine, Department of Developmental Biology, Stanford University School of Medicine, Stanford, United States"},{"name":"Department of Medicine and Liver Center, University of California San Francisco, San Francisco, United 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirleen","family":"Hallang","sequence":"additional","affiliation":[{"name":"Centre for Craniofacial and Regenerative Biology, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0932-8515","authenticated-orcid":true,"given":"Emily J","family":"Lodge","sequence":"additional","affiliation":[{"name":"Centre for Craniofacial and Regenerative Biology, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L","family":"Patist","sequence":"additional","affiliation":[{"name":"Centre for Craniofacial and Regenerative Biology, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schedl","sequence":"additional","affiliation":[{"name":"Universit\u00e9 C\u00f4te d'Azur, Inserm, CNRS, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2324-7589","authenticated-orcid":true,"given":"Patrice","family":"Mollard","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics (IGF), University of Montpellier, CNRS, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel","family":"Nusse","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Stanford University School of Medicine, Department of Developmental Biology, Stanford University School of Medicine, Stanford, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4311-5855","authenticated-orcid":true,"given":"Cynthia L","family":"Andoniadou","sequence":"additional","affiliation":[{"name":"Centre for Craniofacial and Regenerative Biology, King\u2019s College London, London, United Kingdom"},{"name":"Department of Medicine III, 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