{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:55:07Z","timestamp":1790700907306,"version":"4.1.0"},"reference-count":63,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R00 EY026651"],"award-info":[{"award-number":["R00 EY026651"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001694","name":"International Retinal Research Foundation","doi-asserted-by":"publisher","award":["Regular Grant"],"award-info":[{"award-number":["Regular Grant"]}],"id":[{"id":"10.13039\/100001694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["Dr. H. James and Carole Free Career Development"],"award-info":[{"award-number":["Dr. H. James and Carole Free Career Development"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01 EY009339"],"award-info":[{"award-number":["R01 EY009339"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R24 EY027283"],"award-info":[{"award-number":["R24 EY027283"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013510","name":"Eye and Tissue Bank Foundation","doi-asserted-by":"crossref","award":["Postdoctoral Award"],"award-info":[{"award-number":["Postdoctoral Award"]}],"id":[{"id":"10.13039\/501100013510","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003125","name":"Finnish Cultural Foundation","doi-asserted-by":"publisher","award":["Postdoctoral Award"],"award-info":[{"award-number":["Postdoctoral Award"]}],"id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007083","name":"Orion Research Foundation","doi-asserted-by":"publisher","award":["Postdoctoral Award"],"award-info":[{"award-number":["Postdoctoral Award"]}],"id":[{"id":"10.13039\/501100007083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["Unrestricted grant to the Department of Ophthalmology"],"award-info":[{"award-number":["Unrestricted grant to the Department of Ophthalmology"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["Unrestricted grant to the Department of Ophthalmology and Visual Sciences"],"award-info":[{"award-number":["Unrestricted grant to the Department of Ophthalmology and Visual Sciences"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["University of Utah"],"award-info":[{"award-number":["University of Utah"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["University of California Irvine"],"award-info":[{"award-number":["University of California Irvine"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001209","name":"Knights Templar Eye Foundation","doi-asserted-by":"publisher","award":["Career-Starter Research Grant"],"award-info":[{"award-number":["Career-Starter Research Grant"]}],"id":[{"id":"10.13039\/100001209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002089","name":"Fight for Sight","doi-asserted-by":"publisher","award":["Postdoctoral Award"],"award-info":[{"award-number":["Postdoctoral Award"]}],"id":[{"id":"10.13039\/100002089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Neuronal plasticity of the inner retina has been observed in response to photoreceptor degeneration. Typically, this phenomenon has been considered maladaptive and may preclude vision restoration in the blind. However, several recent studies utilizing triggered photoreceptor ablation have shown adaptive responses in bipolar cells expected to support normal vision. Whether such homeostatic plasticity occurs during progressive photoreceptor degenerative disease to help maintain normal visual behavior is unknown. We addressed this issue in an established mouse model of Retinitis Pigmentosa caused by the P23H mutation in rhodopsin. We show robust modulation of the retinal transcriptomic network, reminiscent of the neurodevelopmental state, and potentiation of rod \u2013 rod bipolar cell signaling following rod photoreceptor degeneration. Additionally, we found highly sensitive night vision in P23H mice even when more than half of the rod photoreceptors were lost. These results suggest retinal adaptation leading to persistent visual function during photoreceptor degenerative disease.<\/jats:p>","DOI":"10.7554\/elife.59422","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T12:00:22Z","timestamp":1599739222000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.59422","source":"Crossref","is-referenced-by-count":72,"title":["Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0388-832X","authenticated-orcid":true,"given":"Henri","family":"Leinonen","sequence":"first","affiliation":[{"name":"Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, Irvine, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen C","family":"Pham","sequence":"additional","affiliation":[{"name":"John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Boyd","sequence":"additional","affiliation":[{"name":"John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanes","family":"Santoso","sequence":"additional","affiliation":[{"name":"Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, Irvine, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0788-545X","authenticated-orcid":true,"given":"Krzysztof","family":"Palczewski","sequence":"additional","affiliation":[{"name":"Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, Irvine, United States"},{"name":"Departments of Physiology and Biophysics, and Chemistry, University of California, Irvine, Irvine, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3439-4979","authenticated-orcid":true,"given":"Frans","family":"Vinberg","sequence":"additional","affiliation":[{"name":"John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/S0166-2236(96)80018-X","article-title":"Metaplasticity: the plasticity of synaptic plasticity","volume":"19","author":"Abraham","year":"1996","journal-title":"Trends in Neurosciences"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1016\/S0042-6989(01)00157-2","article-title":"Augmented rod bipolar cell function in partial receptor loss: an ERG study in P23H rhodopsin transgenic and aging normal rats","volume":"41","author":"Aleman","year":"2001","journal-title":"Vision Research"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"4635","DOI":"10.1523\/JNEUROSCI.2570-16.2017","article-title":"Deafferented adult rod bipolar cells create new synapses with photoreceptors to restore vision","volume":"37","author":"Beier","year":"2017","journal-title":"The Journal of Neuroscience"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1016\/j.cub.2018.04.063","article-title":"Stereotyped synaptic connectivity is restored during circuit repair in the adult mammalian retina","volume":"28","author":"Beier","year":"2018","journal-title":"Current Biology"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/j.1463-5224.2009.00694.x","article-title":"The use of canine models of inherited retinal degeneration to test novel therapeutic approaches","volume":"12","author":"Beltran","year":"2009","journal-title":"Veterinary Ophthalmology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1001\/archopht.1991.01080010094039","article-title":"Ocular findings in patients with autosomal dominant retinitis pigmentosa and a rhodopsin gene defect (Pro-23-His)","volume":"109","author":"Berson","year":"1991","journal-title":"Archives of Ophthalmology"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/0042-6989(79)90006-3","article-title":"Barium suppresses slow PIII in perfused bullfrog retina","volume":"19","author":"Bolnick","year":"1979","journal-title":"Vision Research"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.conb.2003.09.007","article-title":"Synaptic gain control and homeostasis","volume":"13","author":"Burrone","year":"2003","journal-title":"Current Opinion in Neurobiology"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1016\/j.celrep.2019.04.065","article-title":"Partial cone loss triggers Synapse-Specific remodeling and spatial receptive field rearrangements in a mature retinal circuit","volume":"27","author":"Care","year":"2019","journal-title":"Cell Reports"},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107730","article-title":"Mature retina compensates functionally for partial loss of rod photoreceptors","volume":"31","author":"Care","year":"2020","journal-title":"Cell Reports"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"XIX","DOI":"10.1007\/978-1-59745-186-4","volume-title":"Retinal Degenerations: Biology, Diagnostics, and Therapeutics","author":"Chang","year":"2007"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.visres.2006.11.020","article-title":"Two mouse retinal degenerations caused by missense mutations in the beta-subunit of rod cGMP phosphodiesterase gene","volume":"47","author":"Chang","year":"2007","journal-title":"Vision Research"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/nn878","article-title":"Critical periods for experience-dependent synaptic scaling in visual cortex","volume":"5","author":"Desai","year":"2002","journal-title":"Nature Neuroscience"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0002-9394(99)00401-8","article-title":"Abnormalities in rod photoreceptors, amacrine cells, and horizontal cells in human retinas with retinitis pigmentosa","volume":"129","author":"Fariss","year":"2000","journal-title":"American Journal of Ophthalmology"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0157","article-title":"Multiple shared mechanisms for homeostatic plasticity in rodent somatosensory and visual cortex","volume":"372","author":"Gainey","year":"2017","journal-title":"Philosophical Transactions of the Royal Society B: Biological Sciences"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/cne.21144","article-title":"Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study","volume":"500","author":"Gargini","year":"2007","journal-title":"The Journal of Comparative Neurology"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1038\/nn1725","article-title":"Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience","volume":"9","author":"Goel","year":"2006","journal-title":"Nature Neuroscience"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"6692","DOI":"10.1523\/JNEUROSCI.5038-06.2007","article-title":"Persistence of experience-induced homeostatic synaptic plasticity through adulthood in superficial layers of mouse visual cortex","volume":"27","author":"Goel","year":"2007","journal-title":"Journal of Neuroscience"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"415","DOI":"10.4196\/kjpp.2011.15.6.415","article-title":"Spontaneous oscillatory rhythm in retinal activities of two retinal degeneration (rd1 and rd10) Mice","volume":"15","author":"Goo","year":"2011","journal-title":"The Korean Journal of Physiology and the Korean Society of Pharmacology"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1016\/S0140-6736(06)69740-7","article-title":"Retinitis pigmentosa","volume":"368","author":"Hartong","year":"2006","journal-title":"The Lancet"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"5248","DOI":"10.1523\/JNEUROSCI.4483-05.2006","article-title":"Synaptic plasticity in CNGA3(-\/-) mice: cone bipolar cells react on the missing cone input and form ectopic synapses with rods","volume":"26","author":"Haverkamp","year":"2006","journal-title":"Journal of Neuroscience"},{"key":"bib22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01332-7","article-title":"Homeostatic plasticity shapes the visual system's first synapse","volume":"8","author":"Johnson","year":"2017","journal-title":"Nature Communications"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cne.10703","article-title":"Retinal remodeling triggered by photoreceptor degenerations","volume":"464","author":"Jones","year":"2003","journal-title":"The Journal of Comparative Neurology"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.exer.2016.03.018","article-title":"Retinal remodeling in human retinitis pigmentosa","volume":"150","author":"Jones","year":"2016","journal-title":"Experimental Eye Research"},{"key":"bib25","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00103","article-title":"Retinal remodeling and metabolic alterations in human AMD","volume":"10","author":"Jones","year":"2016","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.exer.2005.03.006","article-title":"Retinal remodeling during retinal degeneration","volume":"81","author":"Jones","year":"2005","journal-title":"Experimental Eye Research"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.cub.2019.11.021","article-title":"Mice reach higher visual sensitivity at night by using a more efficient behavioral strategy","volume":"30","author":"Koskela","year":"2020","journal-title":"Current Biology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.exer.2017.10.023","article-title":"Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration","volume":"167","author":"LaVail","year":"2018","journal-title":"Experimental Eye Research"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1167\/iovs.19-26560","article-title":"A mixture of U.S. food and drug Administration\u2013Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness","volume":"60","author":"Leinonen","year":"2019","journal-title":"Investigative Opthalmology & Visual Science"},{"key":"bib30","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1523\/JNEUROSCI.15-08-05429.1995","article-title":"Rod photoreceptor neurite sprouting in Retinitis pigmentosa","volume":"15","author":"Li","year":"1995","journal-title":"The Journal of Neuroscience"},{"key":"bib31","first-page":"3200","article-title":"P23H rhodopsin transgenic rat: correlation of retinal function with histopathology","volume":"41","author":"Machida","year":"2000","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/S1350-9462(03)00039-9","article-title":"Neural remodeling in retinal degeneration","volume":"22","author":"Marc","year":"2003","journal-title":"Progress in Retinal and Eye Research"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1385\/MN:28:2:139","article-title":"Retinal remodeling in inherited photoreceptor degenerations","volume":"28","author":"Marc","year":"2003","journal-title":"Molecular Neurobiology"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"6526","DOI":"10.1523\/JNEUROSCI.1533-08.2008","article-title":"Functional stability of retinal ganglion cells after degeneration-induced changes in synaptic input","volume":"28","author":"Margolis","year":"2008","journal-title":"Journal of Neuroscience"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1007\/s00018-012-1230-z","article-title":"Characterization of neurite outgrowth and ectopic synaptogenesis in response to photoreceptor dysfunction","volume":"70","author":"Michalakis","year":"2013","journal-title":"Cellular and Molecular Life Sciences"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/nrn2735","article-title":"Plasticity during stroke recovery: from synapse to behaviour","volume":"10","author":"Murphy","year":"2009","journal-title":"Nature Reviews Neuroscience"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1085\/jgp.200609490","article-title":"Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings","volume":"127","author":"Nikonov","year":"2006","journal-title":"Journal of General Physiology"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1113\/jphysiol.2005.090662","article-title":"Light responses and light adaptation in rat retinal rods at different temperatures","volume":"567","author":"Nymark","year":"2005","journal-title":"The Journal of Physiology"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1124\/jpet.117.245167","article-title":"A combination of G Protein-Coupled receptor modulators protects photoreceptors from degeneration","volume":"364","author":"Orban","year":"2018","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/S1090-0233(98)80028-2","article-title":"A review of research to elucidate the causes of the generalized progressive retinal atrophies","volume":"155","author":"Petersen-Jones","year":"1998","journal-title":"The Veterinary Journal"},{"key":"bib41","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2019.07.004","article-title":"Persistent remodeling and neurodegeneration in late-stage retinal degeneration","volume":"74","author":"Pfeiffer","year":"2020","journal-title":"Progress in Retinal and Eye Research"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s11481-013-9517-x","article-title":"TNF-\u03b1\/NF-\u03baB signaling in the CNS: possible connection to EPHB2","volume":"9","author":"Pozniak","year":"2014","journal-title":"Journal of Neuroimmune Pharmacology"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"4611","DOI":"10.1167\/iovs.04-0541","article-title":"Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system","volume":"45","author":"Prusky","year":"2004","journal-title":"Investigative Opthalmology & Visual Science"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.exer.2018.02.024","article-title":"Loss of cone function without degeneration in a novel Gnat2 knock-out mouse","volume":"171","author":"Ronning","year":"2018","journal-title":"Experimental Eye Research"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1167\/iovs.11-8784","article-title":"Generation of an inbred miniature pig model of retinitis pigmentosa","volume":"53","author":"Ross","year":"2012","journal-title":"Investigative Opthalmology & Visual Science"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"10551","DOI":"10.1074\/jbc.M110.209759","article-title":"Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations","volume":"286","author":"Sakami","year":"2011","journal-title":"Journal of Biological Chemistry"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1093\/hmg\/ddt561","article-title":"P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis","volume":"23","author":"Sakami","year":"2014","journal-title":"Human Molecular Genetics"},{"key":"bib48","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.06358","article-title":"Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior","volume":"4","author":"Sarria","year":"2015","journal-title":"eLife"},{"key":"bib49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.03.033","article-title":"Homeostatic plasticity shapes the retinal response to photoreceptor degeneration","volume":"2","author":"Shen","year":"2020","journal-title":"Current Biology : CB"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1152\/jn.00144.2007","article-title":"Emergence of sustained spontaneous hyperactivity and temporary preservation of OFF responses in ganglion cells of the retinal degeneration (rd1) mouse","volume":"99","author":"Stasheff","year":"2008","journal-title":"Journal of Neurophysiology"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.neuron.2019.02.015","article-title":"Retinoic acid induces hyperactivity, and blocking its receptor unmasks light responses and augments vision in retinal degeneration","volume":"102","author":"Telias","year":"2019","journal-title":"Neuron"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.neuron.2017.04.016","article-title":"Homeostatic plasticity shapes Cell-Type-Specific wiring in the retina","volume":"94","author":"Tien","year":"2017","journal-title":"Neuron"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"13972","DOI":"10.1523\/JNEUROSCI.2399-13.2013","article-title":"Block of gap junctions eliminates aberrant activity and restores light responses during retinal degeneration","volume":"33","author":"Toychiev","year":"2013","journal-title":"Journal of Neuroscience"},{"key":"bib54","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00513","article-title":"A novel retinal oscillation mechanism in an autosomal dominant photoreceptor degeneration mouse model","volume":"9","author":"Tu","year":"2015","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1038\/36103","article-title":"Activity-dependent scaling of quantal amplitude in neocortical neurons","volume":"391","author":"Turrigiano","year":"1998","journal-title":"Nature"},{"key":"bib56","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005736","article-title":"Homeostatic synaptic plasticity: local and global mechanisms for stabilizing neuronal function","volume":"4","author":"Turrigiano","year":"2012","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"bib57","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0258","article-title":"The dialectic of Hebb and homeostasis","volume":"372","author":"Turrigiano","year":"2017","journal-title":"Philosophical Transactions of the Royal Society B: Biological Sciences"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.visres.2014.06.003","article-title":"Ex vivo ERG analysis of photoreceptors using an in vivo ERG system","volume":"101","author":"Vinberg","year":"2014","journal-title":"Vision Research"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"5915","DOI":"10.1093\/hmg\/ddv319","article-title":"A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease","volume":"24","author":"Vinberg","year":"2015","journal-title":"Human Molecular Genetics"},{"key":"bib60","doi-asserted-by":"publisher","DOI":"10.3791\/52855","article-title":"Simultaneous ex vivo functional testing of two retinas by in vivo electroretinogram system","volume":"99","author":"Vinberg","year":"2015","journal-title":"Journal of Visualized Experiments : JoVE"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"15332","DOI":"10.1074\/jbc.RA118.004459","article-title":"The PDE6 mutation in the rd10 retinal degeneration mouse model causes protein mislocalization and instability and promotes cell death through increased ion influx","volume":"293","author":"Wang","year":"2018","journal-title":"Journal of Biological Chemistry"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"6798","DOI":"10.1523\/JNEUROSCI.2902-18.2019","article-title":"Activation of rod input in a model of retinal degeneration reverses retinal remodeling and induces formation of functional synapses and recovery of visual signaling in the adult retina","volume":"39","author":"Wang","year":"2019","journal-title":"The Journal of Neuroscience"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/ar.1092120215","article-title":"Cell differentiation in the retina of the mouse","volume":"212","author":"Young","year":"1985","journal-title":"The Anatomical Record"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/59422\/elife-59422-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/59422\/elife-59422-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/59422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:13:07Z","timestamp":1697058787000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/59422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,22]]},"references-count":63,"alternative-id":["10.7554\/eLife.59422"],"URL":"https:\/\/doi.org\/10.7554\/elife.59422","archive":["CLOCKSS"],"relation":{"is-supplemented-by":[{"id-type":"accession","id":"GSE152474","asserted-by":"subject"},{"id-type":"accession","id":"GSE156533","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.59422.sa2","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.59422.sa1","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.05.28.121673","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,22]]},"article-number":"e59422"}}