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Using the newly fertilized\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    zygote, we show that the mitotic Polo-like kinase PLK-1 phosphorylates the lamin LMN-1 to promote timely lamina disassembly and subsequent merging of the parental genomes into a single nucleus after mitosis. Expression of non-phosphorylatable versions of LMN-1, which affect lamina depolymerization during mitosis, is sufficient to prevent the mixing of the parental chromosomes into a single nucleus in daughter cells. Finally, we recapitulate lamina depolymerization by PLK-1 in vitro demonstrating that LMN-1 is a direct PLK-1 target. Our findings indicate that the timely removal of lamin is essential for the merging of parental chromosomes at the beginning of life in\n                    <jats:italic>C. elegans<\/jats:italic>\n                    and possibly also in humans, where a defect in this process might be fatal for embryo development.\n                  <\/jats:p>","DOI":"10.7554\/elife.59510","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T06:00:11Z","timestamp":1602136811000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.59510","source":"Crossref","is-referenced-by-count":42,"title":["PLK-1 promotes the merger of the parental genome into a single nucleus by triggering lamina disassembly"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9662-8833","authenticated-orcid":true,"given":"Griselda","family":"Velez-Aguilera","sequence":"first","affiliation":[{"name":"Programme Equipe Lab\u00e9llis\u00e9e Ligue Contre le Cancer - Team 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