{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:32:12Z","timestamp":1792427532852,"version":"4.5.0"},"reference-count":52,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["092208\/Z\/10\/Z"],"award-info":[{"award-number":["092208\/Z\/10\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000135","name":"NIH Blueprint for Neuroscience Research","doi-asserted-by":"publisher","award":["R35NS097306"],"award-info":[{"award-number":["R35NS097306"]}],"id":[{"id":"10.13039\/100000135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["A102645"],"award-info":[{"award-number":["A102645"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014895","name":"Open Philanthropy Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Primary sensory neurons are generally considered the only source of dorsal horn calcitonin gene-related peptide (CGRP), a neuropeptide critical to the transmission of pain messages. Using a tamoxifen-inducible\n                    <jats:italic>\n                      Calca\n                      <jats:sup>CreER<\/jats:sup>\n                    <\/jats:italic>\n                    transgenic mouse, here we identified a distinct population of CGRP-expressing excitatory interneurons in lamina III of the spinal cord dorsal horn and trigeminal nucleus caudalis. These interneurons have spine-laden, dorsally directed, dendrites, and ventrally directed axons. As under resting conditions, CGRP interneurons are under tonic inhibitory control, neither innocuous nor noxious stimulation provoked significant Fos expression in these neurons. However, synchronous, electrical non-nociceptive A\u03b2 primary afferent stimulation of dorsal roots depolarized the CGRP interneurons, consistent with their receipt of a VGLUT1 innervation. On the other hand, chemogenetic activation of the neurons produced a mechanical hypersensitivity in response to von Frey stimulation, whereas their caspase-mediated ablation led to mechanical hyposensitivity. Finally, after partial peripheral nerve injury, innocuous stimulation (brush) induced significant Fos expression in the CGRP interneurons. These findings suggest that CGRP interneurons become hyperexcitable and contribute either to ascending circuits originating in deep dorsal horn or to the reflex circuits in baseline conditions, but not in the setting of nerve injury.\n                  <\/jats:p>","DOI":"10.7554\/elife.59751","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T08:02:34Z","timestamp":1622534554000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.59751","source":"Crossref","is-referenced-by-count":39,"title":["Contribution of dorsal horn CGRP-expressing interneurons to mechanical sensitivity"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6762-9717","authenticated-orcid":true,"given":"Line S","family":"L\u00f6ken","sequence":"first","affiliation":[{"name":"Department of Anatomy, University California, San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao M","family":"Braz","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University California, San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Etlin","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University California, San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9769-4082","authenticated-orcid":true,"given":"Mahsa","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University California, San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mollie","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University California, San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Jewell","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University California, San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Steyert","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University California, San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University California, San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Hamel","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University California, San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4269-6846","authenticated-orcid":true,"given":"Ida J","family":"Llewellyn-Smith","sequence":"additional","affiliation":[{"name":"Discipline of Physiology, Adelaide Medical School, University of Adelaide, Adelaide, Australia"},{"name":"Department of Cardiology, Flinders Medical Centre, Bedford Park, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1710-6333","authenticated-orcid":true,"given":"Allan","family":"Basbaum","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University California, San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.cell.2016.12.010","article-title":"The cellular and synaptic\u00a0architecture of the mechanosensory\u00a0dorsal\u00a0horn","volume":"168","author":"Abraira","year":"2017","journal-title":"Cell"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1523\/JNEUROSCI.2559-18.2019","article-title":"Dorsal horn\u00a0gastrin-releasing peptide expressing neurons transmit spinal itch but not pain signals","volume":"39","author":"Albisetti","year":"2019","journal-title":"The Journal of Neuroscience"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1111\/j.1468-2982.2009.01864.x","article-title":"Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice","volume":"30","author":"Bates","year":"2010","journal-title":"Cephalalgia"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1002\/cne.901790107","article-title":"The neurons in the gelatinosal complex (laminae II and III) of the monkey (Macaca mulatta): A golgi study","volume":"179","author":"Beal","year":"1978","journal-title":"The Journal of Comparative Neurology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1126\/science.aac8653","article-title":"Gate control of mechanical itch by a subpopulation of spinal cord interneurons","volume":"350","author":"Bourane","year":"2015","journal-title":"Science"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.cell.2015.01.011","article-title":"Identification of a spinal circuit for light touch and fine motor control","volume":"160","author":"Bourane","year":"2015","journal-title":"Cell"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.celrep.2019.06.040","article-title":"Defining a spinal microcircuit that gates myelinated afferent input: implications for tactile allodynia","volume":"28","author":"Boyle","year":"2019","journal-title":"Cell Reports"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/313054a0","article-title":"Calcitonin gene-related peptide is a potent vasodilator","volume":"313","author":"Brain","year":"1985","journal-title":"Nature"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"9075","DOI":"10.1073\/pnas.0901507106","article-title":"Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli","volume":"106","author":"Cavanaugh","year":"2009","journal-title":"PNAS"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"Journal of Neuroscience Methods"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/nn.4549","article-title":"Identification of spinal circuits involved in touch-evoked dynamic mechanical pain","volume":"20","author":"Cheng","year":"2017","journal-title":"Nature Neuroscience"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"5807","DOI":"10.1523\/JNEUROSCI.3565-17.2018","article-title":"Optogenetic inhibition of CGRP\u03b1 sensory neurons reveals their distinct roles in neuropathic and incisional pain","volume":"38","author":"Cowie","year":"2018","journal-title":"The Journal of Neuroscience"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1097\/j.pain.0000000000001406","article-title":"Morphological and functional properties distinguish the substance P and gastrin-releasing peptide subsets of excitatory interneuron in the spinal cord dorsal horn","volume":"160","author":"Dickie","year":"2019","journal-title":"Pain"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/j.cell.2014.11.003","article-title":"Identification of spinal circuits transmitting and gating mechanical pain","volume":"159","author":"Duan","year":"2014","journal-title":"Cell"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"11634","DOI":"10.1523\/JNEUROSCI.2301-16.2016","article-title":"Functional synaptic integration of forebrain GABAergic precursors into the adult spinal cord","volume":"36","author":"Etlin","year":"2016","journal-title":"The Journal of Neuroscience"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.neuron.2017.01.008","article-title":"A brainstem-spinal cord inhibitory circuit for mechanical pain modulation by GABA and enkephalins","volume":"93","author":"Fran\u00e7ois","year":"2017","journal-title":"Neuron"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1113\/jphysiol.2001.012890","article-title":"Correlations between neuronal morphology and electrophysiological features in the rodent superficial dorsal horn","volume":"540","author":"Grudt","year":"2002","journal-title":"The Journal of Physiology"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1038\/s41593-018-0141-1","article-title":"Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types","volume":"21","author":"H\u00e4ring","year":"2018","journal-title":"Nature Neuroscience"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nrneurol.2010.127","article-title":"CGRP and its receptors provide new insights into migraine pathophysiology","volume":"6","author":"Ho","year":"2010","journal-title":"Nature Reviews Neurology"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41586-018-0793-8","article-title":"Identifying the pathways required for coping behaviours associated with sustained pain","volume":"565","author":"Huang","year":"2019","journal-title":"Nature"},{"key":"bib22","doi-asserted-by":"publisher","DOI":"10.1038\/srep37104","article-title":"Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain","volume":"6","author":"Imlach","year":"2016","journal-title":"Scientific Reports"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/cne.902730203","article-title":"Distribution of calcitonin gene-related peptide immunoreactivity in relation to the rat central somatosensory projection","volume":"273","author":"Kruger","year":"1988","journal-title":"The Journal of Comparative Neurology"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/s41586-018-0515-2","article-title":"Touch and tactile neuropathic pain sensitivity are set by corticospinal projections","volume":"561","author":"Liu","year":"2018","journal-title":"Nature"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1002\/cne.20552","article-title":"Enkephalin-immunoreactive interneurons extensively innervate sympathetic preganglionic neurons regulating the pelvic viscera","volume":"488","author":"Llewellyn-Smith","year":"2005","journal-title":"The Journal of Comparative Neurology"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1002\/cne.24346","article-title":"Long-term, dynamic synaptic reorganization after GABAergic precursor cell transplantation into adult mouse spinal cord","volume":"526","author":"Llewellyn-Smith","year":"2018","journal-title":"Journal of Comparative Neurology"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"4050","DOI":"10.1172\/JCI70026","article-title":"A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia","volume":"123","author":"Lu","year":"2013","journal-title":"Journal of Clinical Investigation"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1126\/science.278.5336.279","article-title":"Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma","volume":"278","author":"Malmberg","year":"1997","journal-title":"Science"},{"key":"bib29","first-page":"155","article-title":"Combined light and electron microscopy of Golgi-labelled neurons in lamina III of the feline spinal cord","volume":"141","author":"Maxwell","year":"1985","journal-title":"Journal of Anatomy"},{"key":"bib30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036355","article-title":"CGRP\u03b1-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch","volume":"7","author":"McCoy","year":"2012","journal-title":"PLOS ONE"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"7936","DOI":"10.1523\/JNEUROSCI.1259-08.2008","article-title":"Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers","volume":"28","author":"Neumann","year":"2008","journal-title":"Journal of Neuroscience"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/syn.10249","article-title":"Cellular localization of three vesicular glutamate transporter mRNAs and proteins in rat spinal cord and dorsal root ganglia","volume":"50","author":"Oliveira","year":"2003","journal-title":"Synapse"},{"key":"bib33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198601","article-title":"Characteristics of sensory neuronal groups in CGRP-cre-ER reporter mice: Comparison to Nav1.8-cre, TRPV1-cre and TRPV1-GFP mouse lines","volume":"13","author":"Patil","year":"2018","journal-title":"PLOS ONE"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.neuron.2015.07.029","article-title":"Dorsal horn circuits for persistent mechanical pain","volume":"87","author":"Peirs","year":"2015","journal-title":"Neuron"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.celrep.2015.09.080","article-title":"Dorsal horn parvalbumin neurons are\u00a0gate-keepers of touch-evoked pain after nerve injury","volume":"13","author":"Petitjean","year":"2015","journal-title":"Cell Reports"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1016\/j.celrep.2019.07.048","article-title":"Recruitment of spinoparabrachial neurons by dorsal horn calretinin neurons","volume":"28","author":"Petitjean","year":"2019","journal-title":"Cell Reports"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1113\/jphysiol.2013.264937","article-title":"Morphological, biophysical and synaptic properties of glutamatergic neurons of the mouse spinal dorsal horn","volume":"592","author":"Punnakkal","year":"2014","journal-title":"The Journal of Physiology"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/0304-3940(88)90544-7","article-title":"Calcitonin gene-related peptide enhances calcium current of rat dorsal root ganglion neurons and spinal excitatory synaptic transmission","volume":"89","author":"Ryu","year":"1988","journal-title":"Neuroscience Letters"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1016\/j.celrep.2018.02.003","article-title":"Massively parallel single nucleus transcriptional profiling defines spinal cord neurons and their activity during behavior","volume":"22","author":"Sathyamurthy","year":"2018","journal-title":"Cell Reports"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/0304-3959(96)03063-1","article-title":"Strychnine-sensitive modulation is selective for non-noxious somatosensory input in the spinal cord of the rat","volume":"66","author":"Sherman","year":"1996","journal-title":"Pain"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1067\/S1526-5900(03)00781-8","article-title":"Spared nerve injury model of neuropathic pain in the mouse: a behavioral and anatomic analysis","volume":"4","author":"Shields","year":"2003","journal-title":"The Journal of Pain"},{"key":"bib42","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.49190","article-title":"Calretinin positive neurons form an excitatory amplifier network in the spinal cord dorsal horn","volume":"8","author":"Smith","year":"2019","journal-title":"eLife"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1523\/JNEUROSCI.2955-14.2015","article-title":"Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns","volume":"35","author":"Solorzano","year":"2015","journal-title":"The Journal of Neuroscience"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"17531","DOI":"10.1073\/pnas.1207238109","article-title":"Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis","volume":"109","author":"Song","year":"2012","journal-title":"PNAS"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/nature06029","article-title":"A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord","volume":"448","author":"Sun","year":"2007","journal-title":"Nature"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1097\/00001756-200103260-00025","article-title":"The expression of calcitonin gene-related peptide in dorsal horn neurons of the mouse lumbar spinal cord","volume":"12","author":"Tie-Jun","year":"2001","journal-title":"Neuroreport"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1523\/JNEUROSCI.4584-05.2006","article-title":"Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord","volume":"26","author":"Torsney","year":"2006","journal-title":"Journal of Neuroscience"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.cophys.2019.10.002","article-title":"Spinal cord projection neurons: a superficial, and also deep analysis","volume":"11","author":"Wercberger","year":"2019","journal-title":"Current Opinion in Physiology"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/0304-3940(86)90195-3","article-title":"Substance P and calcitonin gene-related peptide synergistically modulate the gain of the nociceptive flexor withdrawal reflex in the rat","volume":"66","author":"Woolf","year":"1986","journal-title":"Neuroscience Letters"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.pain.2010.08.008","article-title":"Populations of inhibitory and excitatory interneurons in Lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach","volume":"151","author":"Yasaka","year":"2010","journal-title":"Pain"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/cne.903080212","article-title":"Calcitonin gene-related peptide (CGRP) immunoreactive projections from the thalamus to the striatum and amygdala in the rat","volume":"308","author":"Yasui","year":"1991","journal-title":"The Journal of Comparative Neurology"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/cne.903070408","article-title":"Trigeminal projections to the nucleus submedius of the thalamus in the rat","volume":"307","author":"Yoshida","year":"1991","journal-title":"The Journal of Comparative Neurology"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/59751\/elife-59751-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/59751\/elife-59751-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/59751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:00:33Z","timestamp":1697058033000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/59751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":52,"alternative-id":["10.7554\/eLife.59751"],"URL":"https:\/\/doi.org\/10.7554\/elife.59751","archive":["CLOCKSS"],"relation":{"has-review":[{"id-type":"doi","id":"10.7554\/eLife.59751.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.59751.sa2","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,1]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e59751"}}