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Because CGRP\n                    <jats:sup>PBN<\/jats:sup>\n                    neurons respond broadly to multi-modal threats, it remains unknown how these distinct adaptive processes are individually engaged. We show that while three partially separable subsets of CGRP\n                    <jats:sup>PBN<\/jats:sup>\n                    neurons broadly collateralize to their respective downstream partners, individual projections accomplish distinct functions: hypothalamic and extended amygdalar projections elicit assorted unconditioned threat responses including autonomic arousal, anxiety, and freezing behavior, while thalamic and basal forebrain projections generate freezing behavior and, unexpectedly, contribute to associative fear learning. Moreover, the unconditioned responses generated by individual projections are complementary, with simultaneous activation of multiple sites driving profound freezing behavior and bradycardia that are not elicited by any individual projection. This semi-parallel, scalable connectivity schema likely contributes to flexible control of threat responses in unpredictable environments.\n                  <\/jats:p>","DOI":"10.7554\/elife.59799","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T08:00:25Z","timestamp":1598601625000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.59799","source":"Crossref","is-referenced-by-count":93,"title":["Dissociable control of unconditioned responses and associative fear learning by parabrachial CGRP neurons"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8911-2572","authenticated-orcid":true,"given":"Anna J","family":"Bowen","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Washington, Seattle, United States"},{"name":"Howard Hughes Medical Institute, University of Washington, Seattle, United States"},{"name":"Graduate Program in Neuroscience, University of Washington, Seattle, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3986-8785","authenticated-orcid":true,"given":"Jane Y","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Washington, Seattle, United States"},{"name":"Howard Hughes Medical Institute, University of Washington, Seattle, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y Waterlily","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Washington, Seattle, United States"},{"name":"Howard Hughes Medical Institute, University of Washington, Seattle, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1589-5575","authenticated-orcid":true,"given":"Nathan A","family":"Baertsch","sequence":"additional","affiliation":[{"name":"Center for Integrative Brain Research, Seattle Children\u2019s Research Institute, Seattle, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sekun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Washington, Seattle, United States"},{"name":"Howard Hughes Medical Institute, University of Washington, Seattle, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6587-0582","authenticated-orcid":true,"given":"Richard D","family":"Palmiter","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Washington, Seattle, United States"},{"name":"Howard Hughes Medical Institute, University of Washington, Seattle, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"bib1","first-page":"841","article-title":"Convergence of nociceptive information on the parabrachio-amygdala neurons in the rat","volume":"307","author":"Bernard","year":"1988","journal-title":"Comptes Rendus De l'Academie Des Sciences. 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