{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:54:56Z","timestamp":1790704496765,"version":"4.1.0"},"reference-count":47,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32 AI007641-16"],"award-info":[{"award-number":["T32 AI007641-16"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19AI089674"],"award-info":[{"award-number":["U19AI089674"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["K43TW010365"],"award-info":[{"award-number":["K43TW010365"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["D43TW010526"],"award-info":[{"award-number":["D43TW010526"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Multiple studies have reported a male bias in incidence and\/or prevalence of malaria infection in males compared to females. To test the hypothesis that sex-based differences in host-parasite interactions affect the epidemiology of malaria, we intensively followed\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    infections in a cohort in a malaria endemic area of eastern Uganda and estimated both force of infection (FOI) and rate of clearance using amplicon deep-sequencing. We found no evidence of differences in behavioral risk factors, incidence of malaria, or FOI by sex. In contrast, females cleared asymptomatic infections at a faster rate than males (hazard ratio [HR]=1.82, 95% CI 1.20 to 2.75 by clone and HR = 2.07, 95% CI 1.24 to 3.47 by infection event) in multivariate models adjusted for age, timing of infection onset, and parasite density. These findings implicate biological sex-based differences as an important factor in the host response to this globally important pathogen.\n                  <\/jats:p>","DOI":"10.7554\/elife.59872","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T20:00:22Z","timestamp":1603742422000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.59872","source":"Crossref","is-referenced-by-count":93,"title":["Sex-based differences in clearance of chronic Plasmodium falciparum infection"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8078-3898","authenticated-orcid":true,"given":"Jessica","family":"Briggs","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Teyssier","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaniter I","family":"Nankabirwa","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration, Kampala, Uganda"},{"name":"Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Rek","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6305-758X","authenticated-orcid":true,"given":"Prasanna","family":"Jagannathan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stanford University, Palo Alto, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Arinaitwe","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration, Kampala, Uganda"},{"name":"Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2666-094X","authenticated-orcid":true,"given":"Teun","family":"Bousema","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands"},{"name":"Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4863-075X","authenticated-orcid":true,"given":"Chris","family":"Drakeley","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stanford University, Palo Alto, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Crawford","sequence":"additional","affiliation":[{"name":"Chan-Zuckerberg Biohub, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Hathaway","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Massachusetts, Amherst, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah G","family":"Staedke","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Smith","sequence":"additional","affiliation":[{"name":"Institute for Health Metrics & Evaluation, University of Washington, Seattle, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip J","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Kamya","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration, Kampala, Uganda"},{"name":"Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Dorsey","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6784-1021","authenticated-orcid":true,"given":"Isabel","family":"Rodriguez-Barraquer","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Greenhouse","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-6-97","article-title":"The burden of malaria in Sudan: incidence, mortality and disability--adjusted life--years","volume":"6","author":"Abdalla","year":"2007","journal-title":"Malaria Journal"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"S107","DOI":"10.1093\/infdis\/jit610","article-title":"Sex Bias in the outcome of human tropical infectious diseases: influence of steroid hormones","volume":"209 Suppl 3","author":"Bernin","year":"2014","journal-title":"Journal of Infectious Diseases"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/nrmicro3364","article-title":"Asymptomatic malaria infections: detectability, transmissibility and public health relevance","volume":"12","author":"Bousema","year":"2014","journal-title":"Nature Reviews Microbiology"},{"key":"bib4","article-title":"sex_based_differences","volume-title":"Github","author":"Briggs","year":"2020","unstructured":"Briggs J. 2020. sex_based_differences. Github. jbriggs7. https:\/\/github.com\/EPPIcenter\/sex_based_differences."},{"key":"bib5","doi-asserted-by":"publisher","first-page":"32","DOI":"10.4269\/ajtmh.1996.55.32","article-title":"Hypoendemic malaria in Rondonia (Brazil, western Amazon region): seasonal variation and risk groups in an urban locality","volume":"55","author":"Camargo","year":"1996","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.steroids.2011.05.013","article-title":"Testosterone response of hepatic gene expression in female mice having acquired testosterone-unresponsive immunity to Plasmodium chabaudi malaria","volume":"76","author":"Deli\u0107","year":"2011","journal-title":"Steroids"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S1473-3099(07)70021-X","article-title":"Epidemiology and burden of malaria in pregnancy","volume":"7","author":"Desai","year":"2007","journal-title":"The Lancet Infectious Diseases"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045542","article-title":"The dynamics of natural Plasmodium falciparum infections","volume":"7","author":"Felger","year":"2012","journal-title":"PLOS ONE"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217414","article-title":"Linking human behaviours and malaria vector biting risk in south-eastern Tanzania","volume":"14","author":"Finda","year":"2019","journal-title":"PLOS ONE"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s15010-015-0791-9","article-title":"Sex differences in immune responses to infectious diseases","volume":"43","author":"Fischer","year":"2015","journal-title":"Infection"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/nri2394","article-title":"The X-files in immunity: sex-based differences predispose immune responses","volume":"8","author":"Fish","year":"2008","journal-title":"Nature Reviews Immunology"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1201","article-title":"SeekDeep: single-base resolution de novo clustering for amplicon deep sequencing","volume":"46","author":"Hathaway","year":"2018","journal-title":"Nucleic Acids Research"},{"key":"bib13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001788","article-title":"Ultra-sensitive detection of Plasmodium falciparum by amplification of multi-copy subtelomeric targets","volume":"12","author":"Hofmann","year":"2015","journal-title":"PLOS Medicine"},{"key":"bib14","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-14-7","article-title":"Disparities of Plasmodium falciparum infection, malaria-related morbidity and access to malaria prevention and treatment among school-aged children: a national cross-sectional survey in c\u00f4te d'ivoire","volume":"14","author":"Houngbedji","year":"2015","journal-title":"Malaria Journal"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.0141-9838.2004.00710.x","article-title":"Hormonal and immunological mechanisms mediating sex differences in parasite infection","volume":"26","author":"Klein","year":"2004","journal-title":"Parasite Immunology"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00514-16","article-title":"RTS,S malaria vaccine and increased mortality in girls","volume":"7","author":"Klein","year":"2016","journal-title":"mBio"},{"key":"bib17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019010","article-title":"How much remains undetected? probability of molecular detection of human plasmodia in the field","volume":"6","author":"Koepfli","year":"2011","journal-title":"PLOS ONE"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.pt.2017.08.013","article-title":"Malaria epidemiology at the clone level","volume":"33","author":"Koepfli","year":"2017","journal-title":"Trends in Parasitology"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1128\/IAI.69.1.123-128.2001","article-title":"Human resistance to Plasmodium falciparum increases during puberty and is predicted by dehydroepiandrosterone sulfate levels","volume":"69","author":"Kurtis","year":"2001","journal-title":"Infection and Immunity"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/0035-9203(94)90505-3","article-title":"Parasite density of Plasmodium falciparum malaria in Ghanaian schoolchildren: evidence for influence of sex hormones?","volume":"88","author":"Landgraf","year":"1994","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1086\/376508","article-title":"Dehydroepiandrosterone sulfate levels associated with decreased malaria parasite density and increased hemoglobin concentration in pubertal girls from western Kenya","volume":"188","author":"Leenstra","year":"2003","journal-title":"The Journal of Infectious Diseases"},{"key":"bib22","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-4260-y","article-title":"Development of amplicon deep sequencing markers and data analysis pipeline for genotyping multi-clonal malaria infections","volume":"18","author":"Lerch","year":"2017","journal-title":"BMC Genomics"},{"key":"bib23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39656-7","article-title":"Longitudinal tracking and quantification of individual Plasmodium falciparum clones in complex infections","volume":"9","author":"Lerch","year":"2019","journal-title":"Scientific Reports"},{"key":"bib24","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-017-2137-9","article-title":"A deep sequencing approach to estimate Plasmodium falciparum complexity of infection (COI) and explore apical membrane antigen 1 diversity","volume":"16","author":"Miller","year":"2017","journal-title":"Malaria Journal"},{"key":"bib25","article-title":"The garki project : research on the epidemiology and control of malaria in the Sudan savanna of west africa","volume-title":"World Health Organization","author":"Molineaux","year":"1980","unstructured":"Molineaux L, Gramiccia G, Organization WH. 1980. The garki project : research on the epidemiology and control of malaria in the Sudan savanna of west africa. World Health Organization. https:\/\/apps.who.int\/iris\/handle\/10665\/40316 [Accessed February 18, 2020]."},{"key":"bib26","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3347\/kjp.2001.39.4.293","article-title":"Incidence patterns of vivax malaria in civilians residing in a high-risk county of Kyonggi-do (province), Republic of korea","volume":"39","author":"Moon","year":"2001","journal-title":"The Korean Journal of Parasitology"},{"key":"bib27","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-227","article-title":"Epidemiological and clinical correlates of malaria-helminth co-infections in southern Ethiopia","volume":"12","author":"Mulu","year":"2013","journal-title":"Malaria Journal"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1093\/infdis\/jiy628","article-title":"Persistent parasitemia despite dramatic reduction in malaria incidence after 3 rounds of indoor residual spraying in Tororo, Uganda","volume":"219","author":"Nankabirwa","year":"2019","journal-title":"The Journal of Infectious Diseases"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.4269\/ajtmh.20-0250","article-title":"Malaria transmission, infection, and disease following sustained indoor residual spraying of insecticide in Tororo, Uganda","volume":"103","author":"Nankabirwa","year":"2020","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S1473-3099(18)30046-X","article-title":"The persistence and oscillations of submicroscopic Plasmodium falciparum and Plasmodium vivax infections over time in Vietnam: an open cohort study","volume":"18","author":"Nguyen","year":"2018","journal-title":"The Lancet Infectious Diseases"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"S100","DOI":"10.1093\/infdis\/jiu147","article-title":"Biological differences between the sexes and susceptibility to tuberculosis","volume":"209 Suppl 3","author":"Nhamoyebonde","year":"2014","journal-title":"Journal of Infectious Diseases"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms2241","article-title":"Factors determining the occurrence of submicroscopic malaria infections and their relevance for control","volume":"3","author":"Okell","year":"2012","journal-title":"Nature Communications"},{"key":"bib33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035592","article-title":"Age-dependent sex Bias in clinical malarial disease in Hypoendemic regions","volume":"7","author":"Pathak","year":"2012","journal-title":"PLOS ONE"},{"key":"bib34","article-title":"Python","author":"Python Language Reference","year":"2020","unstructured":"Python Language Reference. 2020. Python. Python Software Foundation. 3.7.4. http:\/\/www.python.org."},{"key":"bib35","article-title":"R: A language and environment for statistical computing","author":"R Development Core Team","year":"2019","unstructured":"R Development Core Team. 2019. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. https:\/\/www.R-project.org."},{"key":"bib36","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1128\/CMR.14.3.476-488.2001","article-title":"Sex-associated hormones and immunity to protozoan parasites","volume":"14","author":"Roberts","year":"2001","journal-title":"Clinical Microbiology Reviews"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v047.i04","article-title":"Frailtypack : An R Package for the Analysis of Correlated Survival Data with Frailty Models Using Penalized Likelihood Estimation or Parametrical Estimation","volume":"47","author":"Rondeau","year":"2012","journal-title":"Journal of Statistical Software"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.cmpb.2005.06.010","article-title":"Frailtypack: a computer program for the analysis of correlated failure time data using penalized likelihood estimation","volume":"80","author":"Rondeau","year":"2005","journal-title":"Computer Methods and Programs in Biomedicine"},{"key":"bib39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042496","article-title":"Estimating the numbers of malaria infections in blood samples using high-resolution genotyping data","volume":"7","author":"Ross","year":"2012","journal-title":"PLOS ONE"},{"key":"bib40","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09441-1","article-title":"The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density","volume":"10","author":"Slater","year":"2019","journal-title":"Nature Communications"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0035-9203(99)90328-0","article-title":"Effect of insecticide-treated bed nets on the dynamics of multiple Plasmodium falciparum infections","volume":"93 Suppl 1","author":"Smith","year":"1999","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/0166-6851(93)90077-B","article-title":"High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction","volume":"61","author":"Snounou","year":"1993","journal-title":"Molecular and Biochemical Parasitology"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1093\/cid\/cix1123","article-title":"The relative contribution of symptomatic and asymptomatic plasmodium vivax and Plasmodium falciparum infections to the infectious reservoir in a Low-Endemic setting in Ethiopia","volume":"66","author":"Tadesse","year":"2018","journal-title":"Clinical Infectious Diseases"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"4468","DOI":"10.1016\/j.vaccine.2019.06.075","article-title":"Irradiated sporozoite vaccination induces sex-specific immune responses and protection against malaria in mice","volume":"37","author":"Vom Steeg","year":"2019","journal-title":"Vaccine"},{"key":"bib45","doi-asserted-by":"crossref","DOI":"10.30875\/7e6f8c91-en","volume-title":"World Malaria Report 2019","author":"World malaria report","year":"2019","unstructured":"World malaria report. 2019. WHO. World Malaria Report 2019. https:\/\/www.who.int\/publications-detail-redirect\/9789241565721."},{"key":"bib46","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/j.1365-3024.1991.tb00289.x","article-title":"Testosterone and other gonadal factor(s) restrict the efficacy of genes controlling resistance to Plasmodium chabaudi malaria","volume":"13","author":"Wunderlich","year":"1991","journal-title":"Parasite Immunology"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/S0020-7519(96)80001-4","article-title":"Sex differences in parasite infections: patterns and processes","volume":"26","author":"Zuk","year":"1996","journal-title":"International Journal for Parasitology"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/59872\/elife-59872-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/59872\/elife-59872-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/59872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:14:07Z","timestamp":1697058847000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/59872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,27]]},"references-count":47,"alternative-id":["10.7554\/eLife.59872"],"URL":"https:\/\/doi.org\/10.7554\/elife.59872","archive":["CLOCKSS"],"relation":{"is-supplemented-by":[{"id-type":"accession","id":"DS_51b40fe2e2","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.59872.sa2","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.59872.sa1","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.06.10.20127720","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,27]]},"article-number":"e59872"}}