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Here, we detail the host immune and metabolic response during sickness and recovery in a mouse model of malaria. We describe extensive alterations in metabolism during acute infection, and identify increases in host-derived metabolites that signal through the aryl hydrocarbon receptor (AHR), a transcription factor with immunomodulatory functions. We find that\n                    <jats:italic>\n                      Ahr\n                      <jats:sup>-\/-<\/jats:sup>\n                    <\/jats:italic>\n                    mice are more susceptible to malaria and develop high plasma heme and acute kidney injury. This phenotype is dependent on AHR in\n                    <jats:italic>Tek<\/jats:italic>\n                    -expressing radioresistant cells. Our findings identify a role for AHR in limiting tissue damage during malaria. Furthermore, this work demonstrates the critical role of host metabolism in surviving infection.\n                  <\/jats:p>","DOI":"10.7554\/elife.60165","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T06:00:18Z","timestamp":1601964018000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.60165","source":"Crossref","is-referenced-by-count":13,"title":["Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3854-2919","authenticated-orcid":true,"given":"Michelle M","family":"Lissner","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Stanford University, Stanford, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Cumnock","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Stanford University, Stanford, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole M","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Stanford University, Stanford, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 G","family":"Vilches-Moure","sequence":"additional","affiliation":[{"name":"Department of Comparative Medicine, Stanford University, Stanford, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8550-7892","authenticated-orcid":true,"given":"Priyanka","family":"Basak","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Stanford University, Stanford, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J","family":"Navarrete","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Stanford University, Stanford, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica A","family":"Allen","sequence":"additional","affiliation":[{"name":"Division of Health, Mathematics and Science, Columbia College, Columbia, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2391-9963","authenticated-orcid":true,"given":"David","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Stanford University, Stanford, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4374","published-online":{"date-parts":[[2020,10,6]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-017-1875-z","article-title":"A metabolomic analytical approach permits identification of urinary biomarkers for Plasmodium falciparum infection: a case-control 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