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We identify genes connected to mitochondrial function and ribosome biogenesis as direct MYC\/HCF-1 targets and demonstrate how modulation of the MYC\u2013HCF-1 interaction influences cell growth, metabolite profiles, global gene expression patterns, and tumor growth in vivo. This work defines HCF-1 as a critical MYC co-factor, places the MYC\u2013HCF-1 interaction in biological context, and highlights HCF-1 as a focal point for development of novel anti-MYC therapies.<\/jats:p>","DOI":"10.7554\/elife.60191","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T09:03:08Z","timestamp":1610096588000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.60191","source":"Crossref","is-referenced-by-count":87,"title":["MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor\u20131"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4694-8804","authenticated-orcid":true,"given":"Tessa M","family":"Popay","sequence":"first","affiliation":[{"name":"Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, United 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