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Ross Chair in Neuromodulation fund","award":["endowment"],"award-info":[{"award-number":["endowment"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY029159"],"award-info":[{"award-number":["R01EY029159"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY028350"],"award-info":[{"award-number":["R01EY028350"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Sciatic nerve crush injury triggers sterile inflammation within the distal nerve and axotomized dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory Ly6C\n                    <jats:sup>high<\/jats:sup>\n                    monocytes infiltrate the nerve first and rapidly give way to Ly6C\n                    <jats:sup>negative<\/jats:sup>\n                    inflammation-resolving macrophages. In axotomized DRGs, few hematogenous leukocytes are detected and resident macrophages acquire a ramified morphology. Single-cell RNA-sequencing of injured sciatic nerve identifies five macrophage subpopulations, repair Schwann cells, and mesenchymal precursor cells. Macrophages at the nerve crush site are molecularly distinct from macrophages associated with Wallerian degeneration. In the injured nerve, macrophages \u2018eat\u2019 apoptotic leukocytes, a process called efferocytosis, and thereby promote an anti-inflammatory milieu. Myeloid cells in the injured nerve, but not axotomized DRGs, strongly express receptors for the cytokine GM-CSF. In GM-CSF-deficient (\n                    <jats:italic>\n                      Csf2\n                      <jats:sup>-\/-<\/jats:sup>\n                    <\/jats:italic>\n                    ) mice, inflammation resolution is delayed and conditioning-lesion-induced regeneration of DRG neuron central axons is abolished. Thus, carefully orchestrated inflammation resolution in the nerve is required for conditioning-lesion-induced neurorepair.\n                  <\/jats:p>","DOI":"10.7554\/elife.60223","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T08:01:40Z","timestamp":1606896100000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.60223","source":"Crossref","is-referenced-by-count":156,"title":["Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-0810","authenticated-orcid":true,"given":"Ashley L","family":"Kalinski","sequence":"first","affiliation":[{"name":"Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, United 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