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However, its impacts on movements and Parkinsonian tremor are unclear. We developed a neurofeedback paradigm targeting STN beta bursts and investigated whether neurofeedback training could improve motor initiation in Parkinson\u2019s disease compared to passive observation. Our task additionally allowed us to test which endogenous changes in oscillatory STN activities are associated with trial-to-trial motor performance. Neurofeedback training reduced beta synchrony and increased gamma activity within the STN, and reduced beta band coupling between the STN and motor cortex. These changes were accompanied by reduced reaction times in subsequently cued movements. However, in Parkinsonian patients with pre-existing symptoms of tremor, successful volitional beta suppression was associated with an amplification of tremor which correlated with theta band activity in STN local field potentials, suggesting an additional cross-frequency interaction between STN beta and theta activities.<\/jats:p>","DOI":"10.7554\/elife.60979","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T06:02:49Z","timestamp":1605679369000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.60979","source":"Crossref","is-referenced-by-count":50,"title":["Subthalamic beta-targeted neurofeedback speeds up movement initiation but increases tremor in Parkinsonian patients"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5269-1902","authenticated-orcid":true,"given":"Shenghong","family":"He","sequence":"first","affiliation":[{"name":"MRC Brain Network Dynamics Unit at the University of Oxford, Oxford, United 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