{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:56:43Z","timestamp":1791381403509,"version":"4.3.3"},"reference-count":62,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["DP2HL13718601"],"award-info":[{"award-number":["DP2HL13718601"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["5T32DK098132-05"],"award-info":[{"award-number":["5T32DK098132-05"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005492","name":"Stanford University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007491","name":"Donald E. and Delia B. Baxter Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Invasion of human erythrocytes by the malaria parasite\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    is a multi-step process. Previously, a forward genetic screen for\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    host factors identified erythrocyte CD55 as essential for invasion, but its specific role and how it interfaces with the other factors that mediate this complex process are unknown. Using CRISPR-Cas9 editing, antibody-based inhibition, and live cell imaging, here we show that CD55 is specifically required for parasite internalization. Pre-invasion kinetics, erythrocyte deformability, and echinocytosis were not influenced by CD55, but entry was inhibited when CD55 was blocked or absent. Visualization of parasites attached to CD55-null erythrocytes points to a role for CD55 in stability and\/or progression of the moving junction. Our findings demonstrate that CD55 acts after discharge of the parasite\u2019s rhoptry organelles, and plays a unique role relative to all other invasion receptors. As the requirement for CD55 is strain-transcendent, these results suggest that CD55 or its interacting partners may hold potential as therapeutic targets for malaria.\n                  <\/jats:p>","DOI":"10.7554\/elife.61516","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T08:00:24Z","timestamp":1621843224000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.61516","source":"Crossref","is-referenced-by-count":28,"title":["Erythrocyte CD55 mediates the internalization of Plasmodium falciparum parasites"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9100-0660","authenticated-orcid":true,"given":"Bikash","family":"Shakya","sequence":"first","affiliation":[{"name":"Departments of Pediatrics and Microbiology & Immunology, Stanford University School of Medicine, Stanford, United 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