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We report a 296 megabase (Mb) reference-quality genome comprised of 17,902 protein-coding genes derived from a single, representative\n                    <jats:italic>Ascaris<\/jats:italic>\n                    worm. An additional 68 worms were collected from 60 human hosts in Kenyan villages where pig husbandry is rare. Notably, the majority of these worms (63\/68) possessed mitochondrial genomes that clustered closer to the pig parasite\n                    <jats:italic>Ascaris suum<\/jats:italic>\n                    than to\n                    <jats:italic>A. lumbricoides<\/jats:italic>\n                    . Comparative phylogenomic analyses identified over 11 million nuclear-encoded SNPs but just two distinct genetic types that had recombined across the genomes analyzed. The nuclear genomes had extensive heterozygosity, and all samples existed as genetic mosaics with either\n                    <jats:italic>A. suum<\/jats:italic>\n                    -like or\n                    <jats:italic>A. lumbricoides<\/jats:italic>\n                    -like inheritance patterns supporting a highly interbred\n                    <jats:italic>Ascaris<\/jats:italic>\n                    species genetic complex. As no barriers appear to exist for anthroponotic transmission of these \u2018hybrid\u2019 worms, a one-health approach to control the spread of human ascariasis will be necessary.\n                  <\/jats:p>","DOI":"10.7554\/elife.61562","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T08:00:35Z","timestamp":1604649635000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.61562","source":"Crossref","is-referenced-by-count":84,"title":["Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4476-9415","authenticated-orcid":true,"given":"Alice","family":"Easton","sequence":"first","affiliation":[{"name":"Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, United States"},{"name":"Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, RNA Bioscience Initiative, University of Colorado School of Medicine, Aurora, United States"},{"name":"Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4055-6524","authenticated-orcid":true,"given":"Scott P","family":"Lawton","sequence":"additional","affiliation":[{"name":"Epidemiology Research Unit (ERU) Department of Veterinary and Animal Sciences, Northern Faculty, Scotland\u2019s Rural College (SRUC), Inverness, United 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Allergy and Infectious Diseases, National Institutes of Health, Hamilton, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita G","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Kepha","sequence":"additional","affiliation":[{"name":"London School of Tropical Medicine and Hygiene, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F","family":"Porcella","sequence":"additional","affiliation":[{"name":"Genomics Unit, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Webster","sequence":"additional","affiliation":[{"name":"Department of Infectious 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