{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:35:49Z","timestamp":1787726149395,"version":"build-2784847793"},"reference-count":32,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIAID ULTIMATE project 1R01AI145781-01"],"award-info":[{"award-number":["NIAID ULTIMATE project 1R01AI145781-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Wellcome International Intermediate Fellowship 206724\/Z\/17\/Z"],"award-info":[{"award-number":["Wellcome International Intermediate Fellowship 206724\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["110179\/Z\/15\/Z"],"award-info":[{"award-number":["110179\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Principal Research Fellowship 103950\/Z\/14"],"award-info":[{"award-number":["Principal Research Fellowship 103950\/Z\/14"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37 AI054503"],"award-info":[{"award-number":["R37 AI054503"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Tuberculous meningitis has high mortality, linked to excessive inflammation. However, adjunctive anti-inflammatory corticosteroids reduce mortality by only 30%, suggesting that inflammatory pathophysiology causes only a subset of deaths. In Vietnam, the survival benefit of anti-inflammatory corticosteroids was most pronounced in patients with a C\/T promoter variant in the leukotriene A\n                    <jats:sub>4<\/jats:sub>\n                    hydrolase (\n                    <jats:italic>LTA4H<\/jats:italic>\n                    ) gene encoding an enzyme that regulates inflammatory eicosanoids.\n                    <jats:italic>LTA4H<\/jats:italic>\n                    TT patients with increased expression had increased survival, consistent with corticosteroids benefiting individuals with hyper-inflammatory responses. However, an Indonesia study did not find an\n                    <jats:italic>LTA4H<\/jats:italic>\n                    TT genotype survival benefit. Here using Bayesian methods to analyse both studies, we find that\n                    <jats:italic>LTA4H<\/jats:italic>\n                    TT genotype confers survival benefit that begins early and continues long-term in both populations. This benefit is nullified in the most severe cases with high early mortality.\n                    <jats:italic>LTA4H<\/jats:italic>\n                    genotyping together with disease severity assessment may target glucocorticoid therapy to patients most likely to benefit from it.\n                  <\/jats:p>","DOI":"10.7554\/elife.61722","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T06:00:20Z","timestamp":1610085620000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.61722","source":"Crossref","is-referenced-by-count":16,"title":["A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival in tuberculous meningitis"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8232-4601","authenticated-orcid":true,"given":"Laura","family":"Whitworth","sequence":"first","affiliation":[{"name":"Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of 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Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofiati","family":"Dian","sequence":"additional","affiliation":[{"name":"Universitas Padjadjaran, TB-HIV Research Center, Faculty of Medicine, Bandung, Indonesia"},{"name":"Department of Neurology, Faculty of Medicine\/Hasan Sadikin Hospital, Universitas Padjadjaran, Sumedang, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bachti","family":"Alisjahbana","sequence":"additional","affiliation":[{"name":"Universitas Padjadjaran, TB-HIV Research Center, Faculty of Medicine, Bandung, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Rizal","family":"Ganiem","sequence":"additional","affiliation":[{"name":"Universitas Padjadjaran, TB-HIV Research Center, Faculty of Medicine, Bandung, Indonesia"},{"name":"Department of Neurology, Faculty of Medicine\/Hasan Sadikin Hospital, Universitas Padjadjaran, Sumedang, 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