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Radial astroglia remodel the IHF to form a continuous substrate between the hemispheres for midline crossing of the corpus callosum (CC) and hippocampal commissure (HC). Deleted in colorectal carcinoma (DCC) and netrin 1 (NTN1) are molecules that have an evolutionarily conserved function in commissural axon guidance. The CC and HC are absent in\n                    <jats:italic>Dcc<\/jats:italic>\n                    and\n                    <jats:italic>Ntn1<\/jats:italic>\n                    knockout mice, while other commissures are only partially affected, suggesting an additional aetiology in forebrain commissure formation. Here, we find that these molecules play a critical role in regulating astroglial development and IHF remodelling during CC and HC formation. Human subjects with\n                    <jats:italic>DCC<\/jats:italic>\n                    mutations display disrupted IHF remodelling associated with CC and HC malformations. Thus, axon guidance molecules such as DCC and NTN1 first regulate the formation of a midline substrate for dorsal commissures prior to their role in regulating axonal growth and guidance across it.\n                  <\/jats:p>","DOI":"10.7554\/elife.61769","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T08:18:47Z","timestamp":1618820327000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.61769","source":"Crossref","is-referenced-by-count":16,"title":["DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6683-4356","authenticated-orcid":true,"given":"Laura","family":"Morcom","sequence":"first","affiliation":[{"name":"The University of Queensland, Queensland Brain Institute, Brisbane, 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