{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:11:13Z","timestamp":1792087873676,"version":"4.4.0"},"reference-count":69,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2013R1A1A2012522"],"award-info":[{"award-number":["2013R1A1A2012522"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1A2B2006310"],"award-info":[{"award-number":["2018R1A2B2006310"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["0320180220: 2018-1293"],"award-info":[{"award-number":["0320180220: 2018-1293"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Derived from a common precursor cell, the balance between Th17 and Treg cells must be maintained within immune system to prevent autoimmune diseases. IL-1\u03b2-mediated IL-1 receptor (IL-1R) signaling is essential for Th17-cell biology. Fine-tuning of IL-1R signaling is controlled by two receptors, IL-1RI and IL-RII, IL-1R accessory protein, and IL-1R antagonist. We demonstrate that the decoy receptor, IL-1RII, is important for regulating IL-17 responses in TCR-stimulated CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells expressing functional IL-1RI via limiting IL-1\u03b2 responsiveness. IL-1RII expression is regulated by NFAT via its interaction with Foxp3. The NFAT\/FOXP3 complex binds to the\n                    <jats:italic>IL-1RII<\/jats:italic>\n                    promoter and is critical for its transcription. Additionally, IL-1RII expression is dysregulated in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells from patients with rheumatoid arthritis. Thus, differential expression of IL-1Rs on activated CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells defines unique immunological features and a novel molecular mechanism underlies IL-1RII expression. These findings shed light on the modulatory effects of IL-1RII on Th17 responses.\n                  <\/jats:p>","DOI":"10.7554\/elife.61841","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T08:06:21Z","timestamp":1611821181000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.61841","source":"Crossref","is-referenced-by-count":22,"title":["Induction of the IL-1RII decoy receptor by NFAT\/FOXP3 blocks IL-1\u03b2-dependent response of Th17 cells"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2765-4376","authenticated-orcid":true,"given":"Dong Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Laboratory of Autoimmunity and Inflammation (LAI), Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Autoimmunity and Inflammation (LAI), Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea"},{"name":"Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea"},{"name":"Cancer Research Institute and Institute of Infectious Diseases, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunjung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Jin","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chungnam National University School of Medicine, 282 Munhwa-ro, Jung-gu, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Life Science, College of Natural Sciences and Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Ran","family":"Yeon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Department of Biomedical Sciences, and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Department of Biomedical Sciences, and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je-Min","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Life Science, College of Natural Sciences and Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Wook","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chungnam National University School of Medicine, 282 Munhwa-ro, Jung-gu, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-9591","authenticated-orcid":true,"given":"Won-Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Autoimmunity and Inflammation (LAI), Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea"},{"name":"Department of Microbiology and Immunology, Seoul 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