{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T05:33:58Z","timestamp":1786858438404,"version":"build-2736575974"},"reference-count":77,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss Cancer Research foundation","award":["KLS-3388-02-2014"],"award-info":[{"award-number":["KLS-3388-02-2014"]}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["Marie Curie Intra-European Fellowships PIEF-GA-2013-629414"],"award-info":[{"award-number":["Marie Curie Intra-European Fellowships PIEF-GA-2013-629414"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009042","name":"University of Seville","doi-asserted-by":"publisher","award":["postdoctoral contract of the V PPIT-US"],"award-info":[{"award-number":["postdoctoral contract of the V PPIT-US"]}],"id":[{"id":"10.13039\/100009042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["CABIMER"],"award-info":[{"award-number":["CABIMER"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>TRIM37 is an E3 ubiquitin ligase mutated in Mulibrey nanism, a disease with impaired organ growth and increased tumor formation. TRIM37 depletion from tissue culture cells results in supernumerary foci bearing the centriolar protein Centrin. Here, we characterize these centriolar protein assemblies (Cenpas) to uncover the mechanism of action of TRIM37. We find that an atypical de novo assembly pathway can generate Cenpas that act as microtubule-organizing centers (MTOCs), including in Mulibrey patient cells. Correlative light electron microscopy reveals that Cenpas are centriole-related or electron-dense structures with stripes. TRIM37 regulates the stability and solubility of Centrobin, which accumulates in elongated entities resembling the striped electron dense structures upon TRIM37 depletion. Furthermore, Cenpas formation upon TRIM37 depletion requires PLK4, as well as two parallel pathways relying respectively on Centrobin and PLK1. Overall, our work uncovers how TRIM37 prevents Cenpas formation, which would otherwise threaten genome integrity.<\/jats:p>","DOI":"10.7554\/elife.62640","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T08:00:45Z","timestamp":1611561645000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.62640","source":"Crossref","is-referenced-by-count":36,"title":["TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2741-6068","authenticated-orcid":true,"given":"Fernando R","family":"Balestra","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica, Universidad de Sevilla, Sevilla, Spain"},{"name":"Centro Andaluz de Biolog\u00eda Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3689-227X","authenticated-orcid":true,"given":"Andr\u00e9s","family":"Dom\u00ednguez-Calvo","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Universidad de Sevilla, Sevilla, Spain"},{"name":"Centro Andaluz de Biolog\u00eda Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5673-4239","authenticated-orcid":true,"given":"Benita","family":"Wolf","sequence":"additional","affiliation":[{"name":"Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Busso","sequence":"additional","affiliation":[{"name":"Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliz\u00e9e","family":"Buff","sequence":"additional","affiliation":[{"name":"Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Averink","sequence":"additional","affiliation":[{"name":"Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marita","family":"Lipsanen-Nyman","sequence":"additional","affiliation":[{"name":"Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1756-4449","authenticated-orcid":true,"given":"Pablo","family":"Huertas","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Universidad de Sevilla, Sevilla, Spain"},{"name":"Centro Andaluz de Biolog\u00eda Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6305-6883","authenticated-orcid":true,"given":"Pierre","family":"G\u00f6nczy","sequence":"additional","affiliation":[{"name":"Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1242\/jcs.069963","article-title":"SPICE--a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression","volume":"123","author":"Archinti","year":"2010","journal-title":"Journal of Cell Science"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.cub.2013.12.016","article-title":"STIL microcephaly mutations interfere with APC\/C-mediated degradation and cause centriole amplification","volume":"24","author":"Arquint","year":"2014","journal-title":"Current Biology"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/77053","article-title":"Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism","volume":"25","author":"Avela","year":"2000","journal-title":"Nature Genetics"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1083\/jcb.200808082","article-title":"hPOC5 is a centrin-binding protein required for assembly of full-length centrioles","volume":"185","author":"Azimzadeh","year":"2009","journal-title":"Journal of Cell Biology"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.devcel.2013.05.016","article-title":"Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells","volume":"25","author":"Balestra","year":"2013","journal-title":"Developmental Cell"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1146\/annurev-cellbio-100616-060454","article-title":"Centriole biogenesis: from identifying the characters to understanding the plot","volume":"33","author":"Banterle","year":"2017","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.tig.2011.05.004","article-title":"Centrosomes and cilia in human disease","volume":"27","author":"Bettencourt-Dias","year":"2011","journal-title":"Trends in Genetics"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/nature13955","article-title":"TRIM37 is a new histone H2A ubiquitin ligase and breast Cancer oncoprotein","volume":"516","author":"Bhatnagar","year":"2014","journal-title":"Nature"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1126\/science.1209037","article-title":"The centrosome in cells and organisms","volume":"335","author":"Bornens","year":"2012","journal-title":"Science"},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069986","article-title":"Cep63 and cep152 cooperate to ensure centriole duplication","volume":"8","author":"Brown","year":"2013","journal-title":"PLOS ONE"},{"key":"bib11","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0468","article-title":"Small organelle, big responsibility: the role of centrosomes in development and disease","volume":"369","author":"Chavali","year":"2014","journal-title":"Philosophical Transactions of the Royal Society B: Biological Sciences"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1083\/jcb.201007107","article-title":"Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome","volume":"191","author":"Cizmecioglu","year":"2010","journal-title":"Journal of Cell Biology"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1016\/j.cub.2013.06.002","article-title":"CEP120 and SPICE1 cooperate with CPAP in centriole elongation","volume":"23","author":"Comartin","year":"2013","journal-title":"Current Biology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1083\/jcb.201202135","article-title":"The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development","volume":"198","author":"Courtois","year":"2012","journal-title":"Journal of Cell Biology"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1242\/jcs.02302","article-title":"Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function","volume":"118","author":"Delgehyr","year":"2005","journal-title":"Journal of Cell Science"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"6280","DOI":"10.1038\/sj.onc.1210456","article-title":"Centriole overduplication through the concurrent formation of multiple daughter centrioles at single maternal templates","volume":"26","author":"Duensing","year":"2007","journal-title":"Oncogene"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/cm.21284","article-title":"Rapid centriole assembly in Naegleria reveals conserved roles for both de novo and mentored assembly","volume":"73","author":"Fritz-Laylin","year":"2016","journal-title":"Cytoskeleton"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1083\/jcb.51.3.826","article-title":"Basal bodies, but not centrioles, in Naegleria","volume":"51","author":"Fulton","year":"1971","journal-title":"Journal of Cell Biology"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41592-018-0238-1","article-title":"Imaging cellular ultrastructures using expansion microscopy (U-ExM)","volume":"16","author":"Gambarotto","year":"2019","journal-title":"Nature Methods"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/nature08136","article-title":"A mechanism linking extra centrosomes to chromosomal instability","volume":"460","author":"Ganem","year":"2009","journal-title":"Nature"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/nature13277","article-title":"Oncogene-like induction of cellular invasion from centrosome amplification","volume":"510","author":"Godinho","year":"2014","journal-title":"Nature"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nrc3995","article-title":"Centrosomes and Cancer: revisiting a long-standing relationship","volume":"15","author":"G\u00f6nczy","year":"2015","journal-title":"Nature Reviews Cancer"},{"key":"bib23","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.228833","article-title":"Centriole assembly at a glance","volume":"132","author":"G\u00f6nczy","year":"2019","journal-title":"Journal of Cell Science"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1083\/jcb.201006135","article-title":"Centrobin-tubulin interaction is required for centriole elongation and stability","volume":"193","author":"Gudi","year":"2011","journal-title":"Journal of Cell Biology"},{"key":"bib25","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14813","article-title":"Cell-free reconstitution reveals centriole cartwheel assembly mechanisms","volume":"8","author":"Guichard","year":"2017","journal-title":"Nature Communications"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"1700241","DOI":"10.1002\/bies.201700241","article-title":"The rise of the cartwheel: seeding the centriole organelle","volume":"40","author":"Guichard","year":"2018","journal-title":"BioEssays"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1038\/ncb1320","article-title":"The polo kinase Plk4 functions in centriole duplication","volume":"7","author":"Habedanck","year":"2005","journal-title":"Nature Cell Biology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1083\/jcb.201006049","article-title":"Cep152 interacts with Plk4 and is required for centriole duplication","volume":"191","author":"Hatch","year":"2010","journal-title":"Journal of Cell Biology"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"20130458","DOI":"10.1098\/rstb.2013.0458","article-title":"Cartwheel assembly","volume":"369","author":"Hirono","year":"2014","journal-title":"Philosophical Transactions of the Royal Society B: Biological Sciences"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.3892\/mmr.2017.6125","article-title":"TRIM37 promotes epithelialmesenchymal transition in colorectal Cancer","volume":"15","author":"Hu","year":"2017","journal-title":"Molecular Medicine Reports"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1242\/jcs.03458","article-title":"Characterization of NIP2\/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization","volume":"120","author":"Jeong","year":"2007","journal-title":"Journal of Cell Science"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1016\/j.bbrc.2015.07.089","article-title":"Over-expression of TRIM37 promotes cell migration and metastasis in hepatocellular carcinoma by activating wnt\/\u03b2-catenin signaling","volume":"464","author":"Jiang","year":"2015","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1086\/340256","article-title":"The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder","volume":"70","author":"Kallij\u00e4rvi","year":"2002","journal-title":"The American Journal of Human Genetics"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.yexcr.2005.04.001","article-title":"TRIM37 defective in Mulibrey nanism is a novel RING finger ubiquitin E3 ligase","volume":"308","author":"Kallij\u00e4rvi","year":"2005","journal-title":"Experimental Cell Research"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1002\/path.2538","article-title":"High frequency of tumours in Mulibrey nanism","volume":"218","author":"Karlberg","year":"2009","journal-title":"The Journal of Pathology"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1242\/bio.016246","article-title":"Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism","volume":"5","author":"Kettunen","year":"2016","journal-title":"Biology Open"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1083\/jcb.200205102","article-title":"De novo formation of centrosomes in vertebrate cells arrested during S phase","volume":"158","author":"Khodjakov","year":"2002","journal-title":"Journal of Cell Biology"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"3884","DOI":"10.1242\/jcs.089888","article-title":"Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL","volume":"124","author":"Kitagawa","year":"2011","journal-title":"Journal of Cell Science"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.cell.2011.01.008","article-title":"Structural basis of the 9-fold symmetry of centrioles","volume":"144","author":"Kitagawa","year":"2011","journal-title":"Cell"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"E657","DOI":"10.1073\/pnas.1417967112","article-title":"Autoinhibition and relief mechanism for Polo-like kinase 4","volume":"112","author":"Klebba","year":"2015","journal-title":"PNAS"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.cub.2009.05.018","article-title":"Overly long centrioles and defective cell division upon excess of the SAS-4-related protein CPAP","volume":"19","author":"Kohlmaier","year":"2009","journal-title":"Current Biology"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1083\/jcb.200411126","article-title":"The de novo centriole assembly pathway in HeLa cells: cell cycle progression and centriole assembly\/maturation","volume":"168","author":"La Terra","year":"2005","journal-title":"The Journal of Cell Biology"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.devcel.2016.12.022","article-title":"Centrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals","volume":"40","author":"Levine","year":"2017","journal-title":"Developmental Cell"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/embor.2012.40","article-title":"Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres","volume":"13","author":"Li","year":"2012","journal-title":"EMBO Reports"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.cub.2010.05.050","article-title":"Centriole reduplication during prolonged interphase requires procentriole maturation governed by Plk1","volume":"20","author":"Loncarek","year":"2010","journal-title":"Current Biology"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.cub.2012.12.030","article-title":"Selective chemical crosslinking reveals a Cep57-Cep63-Cep152 centrosomal complex","volume":"23","author":"Lukinavi\u010dius","year":"2013","journal-title":"Current Biology"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1016\/j.cub.2012.06.057","article-title":"Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling","volume":"22","author":"Mahjoub","year":"2012","journal-title":"Current Biology"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1083\/jcb.201604081","article-title":"53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration","volume":"214","author":"Meitinger","year":"2016","journal-title":"Journal of Cell Biology"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/s41586-020-2710-1","article-title":"TRIM37 controls cancer-specific vulnerability to PLK4 inhibition","volume":"585","author":"Meitinger","year":"2020","journal-title":"Nature"},{"key":"bib50","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.219501","article-title":"PLK4 is a microtubule-associated protein that self-assembles promoting de novo MTOC formation","volume":"132","author":"Montenegro Gouveia","year":"2018","journal-title":"Journal of Cell Science"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1083\/jcb.201502088","article-title":"Binding of STIL to Plk4 activates kinase activity to promote centriole assembly","volume":"209","author":"Moyer","year":"2015","journal-title":"Journal of Cell Biology"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/nrm.2017.127","article-title":"Once and only once: mechanisms of centriole duplication and their deregulation in disease","volume":"19","author":"Nigg","year":"2018","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.cell.2009.10.036","article-title":"Centrioles, centrosomes, and cilia in health and disease","volume":"139","author":"Nigg","year":"2009","journal-title":"Cell"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1083\/jcb.201706095","article-title":"Centrobin controls primary ciliogenesis in vertebrates","volume":"217","author":"Ogungbenro","year":"2018","journal-title":"Journal of Cell Biology"},{"key":"bib55","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6267","article-title":"Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole","volume":"5","author":"Ohta","year":"2014","journal-title":"Nature Communications"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1083\/jcb.149.2.317","article-title":"The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cells","volume":"149","author":"Piel","year":"2000","journal-title":"Journal of Cell Biology"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.cub.2009.05.016","article-title":"Control of centriole length by CPAP and CP110","volume":"19","author":"Schmidt","year":"2009","journal-title":"Current Biology"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/978-1-60327-993-2_7","article-title":"Automated live microscopy to study mitotic gene function in fluorescent reporter cell lines","volume":"545","author":"Schmitz","year":"2009","journal-title":"Methods in Molecular Biology"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/ncb3270","article-title":"Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis","volume":"18","author":"Ser\u00e7in","year":"2016","journal-title":"Nature Cell Biology"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1080\/15384101.2015.1041683","article-title":"The microtubule nucleation activity of centrobin in both the centrosome and cytoplasm","volume":"14","author":"Shin","year":"2015","journal-title":"Cell Cycle"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"97","DOI":"10.15252\/embj.201488979","article-title":"RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity","volume":"34","author":"Shiratsuchi","year":"2015","journal-title":"The EMBO Journal"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1091\/mbc.e09-06-0505","article-title":"Autophosphorylation of polo-like kinase 4 and its role in centriole duplication","volume":"21","author":"Sillibourne","year":"2010","journal-title":"Molecular Biology of the Cell"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1023\/A:1023081624133","article-title":"The 17q23 amplicon and breast Cancer","volume":"78","author":"Sinclair","year":"2003","journal-title":"Breast Cancer Research and Treatment"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1038\/ng.971","article-title":"A primary microcephaly protein complex forms a ring around parental centrioles","volume":"43","author":"Sir","year":"2011","journal-title":"Nature Genetics"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.devcel.2007.07.004","article-title":"Regulated HsSAS-6 levels ensure formation of a single procentriole per centriole during the centrosome duplication cycle","volume":"13","author":"Strnad","year":"2007","journal-title":"Developmental Cell"},{"key":"bib66","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061429","article-title":"With age comes maturity: biochemical and structural transformation of a human centriole in the making","volume":"9","author":"Sullenberger","year":"2020","journal-title":"Cells"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/ncb1889","article-title":"CPAP is a cell-cycle regulated protein that controls centriole length","volume":"11","author":"Tang","year":"2009","journal-title":"Nature Cell Biology"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1038\/ng.3031","article-title":"The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation","volume":"46","author":"Thauvin-Robinet","year":"2014","journal-title":"Nature Genetics"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.devcel.2009.07.015","article-title":"Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells","volume":"17","author":"Tsou","year":"2009","journal-title":"Developmental Cell"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1126\/science.1199325","article-title":"Structures of SAS-6 suggest its organization in centrioles","volume":"331","author":"van Breugel","year":"2011","journal-title":"Science"},{"key":"bib71","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10586","article-title":"De novo centriole formation in human cells is error-prone and does not require SAS-6 self-assembly","volume":"4","author":"Wang","year":"2015","journal-title":"eLife"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1083\/jcb.201611170","article-title":"TRIM37, a novel E3 ligase for PEX5-mediated peroxisomal matrix protein import","volume":"216","author":"Wang","year":"2017","journal-title":"Journal of Cell Biology"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/0092-8674(95)90435-2","article-title":"Identification of a signal for rapid export of proteins from the nucleus","volume":"82","author":"Wen","year":"1995","journal-title":"Cell"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1126\/science.aaa5111","article-title":"Cell biology. reversible centriole depletion with an inhibitor of Polo-like kinase 4","volume":"348","author":"Wong","year":"2015","journal-title":"Science"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/s41586-020-2690-1","article-title":"Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast Cancer","volume":"585","author":"Yeow","year":"2020","journal-title":"Nature"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.cub.2007.12.055","article-title":"The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis","volume":"18","author":"Zhu","year":"2008","journal-title":"Current Biology"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1083\/jcb.200506185","article-title":"Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication","volume":"171","author":"Zou","year":"2005","journal-title":"The Journal of Cell Biology"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/62640\/elife-62640-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/62640\/elife-62640-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/62640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:03:39Z","timestamp":1697058219000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/62640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,25]]},"references-count":77,"alternative-id":["10.7554\/eLife.62640"],"URL":"https:\/\/doi.org\/10.7554\/elife.62640","archive":["CLOCKSS"],"relation":{"has-review":[{"id-type":"doi","id":"10.7554\/eLife.62640.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.62640.sa2","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.09.03.281097","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,25]]},"article-number":"e62640"}}