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To test this model, we studied conditional knockout mice in which the vast majority of dentate granule cells (DGCs) fail to develop \u2013 including nearly all DGCs in the dorsal hippocampus \u2013 secondary to eliminating\n                    <jats:italic>Wntless<\/jats:italic>\n                    (\n                    <jats:italic>Wls<\/jats:italic>\n                    ) in a subset of cortical progenitors with\n                    <jats:italic>Gfap-Cre<\/jats:italic>\n                    . Other cells in the\n                    <jats:italic>\n                      Wls\n                      <jats:sup>fl\/-<\/jats:sup>\n                      ;Gfap-Cre\n                    <\/jats:italic>\n                    hippocampus were minimally affected, as determined by single nucleus RNA sequencing. CA3 pyramidal cells, the targets of DGC-derived mossy fibers, exhibited normal morphologies with a small reduction in the numbers of synaptic spines.\n                    <jats:italic>\n                      Wls\n                      <jats:sup>fl\/-<\/jats:sup>\n                      ;Gfap-Cre\n                    <\/jats:italic>\n                    mice have a modest performance decrement in several complex spatial tasks, including active place avoidance. They were also modestly impaired in one simpler spatial task, finding a visible platform in the Morris water maze. These experiments support a role for DGCs in enhancing spatial learning and memory.\n                  <\/jats:p>","DOI":"10.7554\/elife.62766","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T06:00:18Z","timestamp":1603260018000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.62766","source":"Crossref","is-referenced-by-count":4,"title":["Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9542-6212","authenticated-orcid":true,"given":"Amir","family":"Rattner","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantelle E","family":"Terrillion","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Jou","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Robert F. 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