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In contrast, immunity to severe disease can be acquired quickly and without the need for improved pathogen control (tolerance). Using\n                    <jats:italic>Plasmodium chabaudi<\/jats:italic>\n                    , we show that a single malaria episode is sufficient to induce host adaptations that can minimise inflammation, prevent tissue damage and avert endothelium activation, a hallmark of severe disease. Importantly, monocytes are functionally reprogrammed to prevent their differentiation into inflammatory macrophages and instead promote mechanisms of stress tolerance to protect their niche. This alternative fate is not underpinned by epigenetic reprogramming of bone marrow progenitors but appears to be imprinted within the remodelled spleen. Crucially, all of these adaptations operate independently of pathogen load and limit the damage caused by malaria parasites in subsequent infections. Acquired immunity to malaria therefore prioritises host fitness over pathogen clearance.\n                  <\/jats:p>","DOI":"10.7554\/elife.63838","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T20:00:24Z","timestamp":1616443224000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.63838","source":"Crossref","is-referenced-by-count":70,"title":["Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4503-8761","authenticated-orcid":true,"given":"Wiebke","family":"Nahrendorf","sequence":"first","affiliation":[{"name":"Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alasdair","family":"Ivens","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom"},{"name":"Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5506-2773","authenticated-orcid":true,"given":"Philip J","family":"Spence","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom"},{"name":"Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-017-1796-x","article-title":"Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity","volume":"16","author":"Ademolue","year":"2017","journal-title":"Malaria 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