{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:15:08Z","timestamp":1783124108621,"version":"3.54.6"},"reference-count":68,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 NS097340"],"award-info":[{"award-number":["R35 NS097340"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["IOS-1853719"],"award-info":[{"award-number":["IOS-1853719"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    The Roundabout (Robo) guidance receptor family induces axon repulsion in response to its ligand Slit by inducing local cytoskeletal changes; however, the link to the cytoskeleton and the nature of these cytoskeletal changes are poorly understood. Here, we show that the heteropentameric Scar\/Wave Regulatory Complex (WRC), which drives Arp2\/3-induced branched actin polymerization, is a direct effector of Robo signaling. Biochemical evidence shows that Slit triggers WRC recruitment to the Robo receptor\u2019s WRC-interacting receptor sequence (WIRS) motif. In\n                    <jats:italic>Drosophila<\/jats:italic>\n                    embryos, mutants of the WRC enhance Robo1-dependent midline crossing defects. Additionally, mutating Robo1\u2019s WIRS motif significantly reduces receptor activity in rescue assays in vivo, and CRISPR-Cas9 mutagenesis shows that the WIRS motif is essential for endogenous Robo1 function. Finally, axon guidance assays in mouse dorsal spinal commissural axons and gain-of-function experiments in chick embryos demonstrate that the WIRS motif is also required for Robo1 repulsion in mammals. Together, our data support an essential conserved role for the WIRS-WRC interaction in Robo1-mediated axon repulsion.\n                  <\/jats:p>","DOI":"10.7554\/elife.64474","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T10:00:35Z","timestamp":1618221635000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.64474","source":"Crossref","is-referenced-by-count":19,"title":["Robo recruitment of the Wave regulatory complex plays an essential and conserved role in midline repulsion"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3533-3027","authenticated-orcid":true,"given":"Karina","family":"Chaudhari","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhavi","family":"Gorla","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chang","sequence":"additional","affiliation":[{"name":"Institut de recherches cliniques de Montr\u00e9al (IRCM), Montr\u00e9al, Canada"},{"name":"Department of Anatomy and Cell Biology and Division of Experimental Medicine, McGill University, Montr\u00e9al, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5209-2520","authenticated-orcid":true,"given":"Artur","family":"Kania","sequence":"additional","affiliation":[{"name":"Institut de recherches cliniques de Montr\u00e9al (IRCM), Montr\u00e9al, Canada"},{"name":"Department of Anatomy and Cell Biology and Division of Experimental Medicine, McGill University, Montr\u00e9al, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6146-0962","authenticated-orcid":true,"given":"Greg J","family":"Bashaw","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00081","article-title":"CYFIP family proteins between autism and intellectual disability: links with fragile X syndrome","volume":"8","author":"Abekhoukh","year":"2014","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1002\/ajmg.b.30697","article-title":"Genetic analyses of roundabout (ROBO) axon guidance receptors in autism","volume":"147B","author":"Anitha","year":"2008","journal-title":"American Journal of Medical Genetics. 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