{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T08:29:46Z","timestamp":1772267386225,"version":"3.50.1"},"reference-count":50,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["STR 1095\/6-1"],"award-info":[{"award-number":["STR 1095\/6-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010564","name":"Deutsche Zentrum f\u00fcr Lungenforschung","doi-asserted-by":"crossref","award":["82DZL002A"],"award-info":[{"award-number":["82DZL002A"]}],"id":[{"id":"10.13039\/501100010564","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB\/TRR57"],"award-info":[{"award-number":["SFB\/TRR57"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Expression levels of CX3CR1 (C-X3-C motif chemokine receptor 1) on immune cells have significant importance in maintaining tissue homeostasis under physiological and pathological conditions. The factors implicated in the regulation of CX3CR1 and its specific ligand CX3CL1 (fractalkine) expression remain largely unknown. Recent studies provide evidence that host\u2019s misfolded proteins occurring in the forms of polymers or amyloid fibrils can regulate CX3CR1 expression. Herein, a novel example demonstrates that polymers of human ZZ alpha-1 antitrypsin (Z-AAT) protein, resulting from its conformational misfolding due to the Z (Glu342Lys) mutation in\n                    <jats:italic>SERPINA1<\/jats:italic>\n                    gene, strongly lower CX3CR1 mRNA expression in human peripheral blood mononuclear cells (PBMCs). This parallels with increase of intracellular levels of CX3CR1 and Z-AAT proteins. Presented data indicate the involvement of the CX3CR1 pathway in the Z-AAT-related disorders and further support the role of misfolded proteins in CX3CR1 regulation.\n                  <\/jats:p>","DOI":"10.7554\/elife.64881","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T08:00:34Z","timestamp":1621324834000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.64881","source":"Crossref","is-referenced-by-count":4,"title":["Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0363-3914","authenticated-orcid":true,"given":"Srinu","family":"Tumpara","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Hannover Medical School, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1352-5995","authenticated-orcid":true,"given":"Matthias","family":"Ballmaier","sequence":"additional","affiliation":[{"name":"Cell Sorting Core Facility Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9733-6162","authenticated-orcid":true,"given":"Sabine","family":"Wrenger","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Hannover Medical School, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"8sens.biognostic GmbH, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Lehmann","sequence":"additional","affiliation":[{"name":"8sens.biognostic GmbH, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Lichtinghagen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6834-350X","authenticated-orcid":true,"given":"Beatriz","family":"Martinez-Delgado","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Institute of Health Carlos III, Center for Biomedical Research in the Network of Rare Diseases (CIBERER), Majadahonda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Korenbaum","sequence":"additional","affiliation":[{"name":"Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0141-9116","authenticated-orcid":true,"given":"David","family":"DeLuca","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Hannover Medical School, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Jedicke","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Welte","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Hannover Medical School, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malin","family":"Fromme","sequence":"additional","affiliation":[{"name":"Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Strnad","sequence":"additional","affiliation":[{"name":"Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Stolk","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Leiden University Medical Center, Member of European Reference Network LUNG, section Alpha-1-antitrypsin Deficiency, Leiden, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7687-5258","authenticated-orcid":true,"given":"Sabina","family":"Janciauskiene","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Hannover Medical School, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany"},{"name":"Department of Pulmonology, Leiden University Medical Center, Member of European Reference Network LUNG, section Alpha-1-antitrypsin Deficiency, Leiden, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4374","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1081\/COPD-120030828","article-title":"Analysis of systemic biomarkers in COPD patients","volume":"1","author":"Aldonyte","year":"2004","journal-title":"COPD: Journal of Chronic Obstructive Pulmonary Disease"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.imlet.2013.03.004","article-title":"Sources of heterogeneity in human monocyte subsets","volume":"152","author":"Appleby","year":"2013","journal-title":"Immunology Letters"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1126\/science.1142883","article-title":"Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior","volume":"317","author":"Auffray","year":"2007","journal-title":"Science"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1146\/annurev.immunol.021908.132557","article-title":"Blood monocytes: development, heterogeneity, and relationship with dendritic cells","volume":"27","author":"Auffray","year":"2009","journal-title":"Annual Review of Immunology"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/pr.113.007724","article-title":"International union of basic and clinical pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors","volume":"66","author":"Bachelerie","year":"2014","journal-title":"Pharmacological Reviews"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"3494","DOI":"10.1182\/blood-2003-03-0946","article-title":"IL-15 and IL-2 oppositely regulate expression of the chemokine receptor CX3CR1","volume":"102","author":"Barlic","year":"2003","journal-title":"Blood"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/385640a0","article-title":"A new class of membrane-bound chemokine with a CX3C motif","volume":"385","author":"Bazan","year":"1997","journal-title":"Nature"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"3183","DOI":"10.2147\/COPD.S276792","article-title":"Monocytes and Macrophages in Alpha-1 Antitrypsin Deficiency","volume":"15","author":"Belchamber","year":"2020","journal-title":"International journal of chronic obstructive pulmonary disease"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0200-1","article-title":"Absence of CX3CR1 impairs the internalization of Tau by microglia","volume":"12","author":"Bol\u00f3s","year":"2017","journal-title":"Molecular Neurodegeneration"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"952","DOI":"10.4049\/jimmunol.1004164","article-title":"Cutting edge: protective effect of CX3CR1+ dendritic cells in a vaccinia virus pulmonary infection model","volume":"188","author":"Bonduelle","year":"2012","journal-title":"The Journal of Immunology"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1182\/blood-2007-10-118497","article-title":"Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues","volume":"112","author":"Cardona","year":"2008","journal-title":"Blood"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-020-00474-4","article-title":"Interaction of tau with the chemokine receptor, CX3CR1 and its effect on microglial activation, migration and proliferation","volume":"10","author":"Chidambaram","year":"2020","journal-title":"Cell & Bioscience"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"32713","DOI":"10.1074\/jbc.M111.254268","article-title":"CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease","volume":"286","author":"Cho","year":"2011","journal-title":"Journal of Biological Chemistry"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.immuni.2010.08.012","article-title":"Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors","volume":"33","author":"Cros","year":"2010","journal-title":"Immunity"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.94605","article-title":"Respiratory syncytial virus infection of newborn CX3CR1-deficient mice induces a pathogenic pulmonary innate immune response","volume":"2","author":"Das","year":"2017","journal-title":"JCI Insight"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.jaci.2004.02.030","article-title":"Expression of fractalkine and its receptor, CX3CR1, in atopic dermatitis: possible contribution to skin inflammation","volume":"113","author":"Echigo","year":"2004","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"5354","DOI":"10.4049\/jimmunol.1400378","article-title":"Acute-phase protein \u03b11-antitrypsin--a novel regulator of angiopoietin-like protein 4 transcription and secretion","volume":"192","author":"Frenzel","year":"2014","journal-title":"The Journal of Immunology"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","article-title":"Blood monocytes consist of two principal subsets with distinct migratory properties","volume":"19","author":"Geissmann","year":"2003","journal-title":"Immunity"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"10896","DOI":"10.1073\/pnas.95.18.10896","article-title":"Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia","volume":"95","author":"Harrison","year":"1998","journal-title":"PNAS"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"30225","DOI":"10.1074\/jbc.M802638200","article-title":"Functional adhesiveness of the CX3CL1 chemokine requires its aggregation. Role of the transmembrane domain","volume":"283","author":"Hermand","year":"2008","journal-title":"The Journal of Biological Chemistry"},{"key":"bib21","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-016-0017-2","article-title":"Therapeutic intervention of inflammatory\/immune diseases by inhibition of the fractalkine (CX3CL1)-CX3CR1 pathway","volume":"36","author":"Imai","year":"2016","journal-title":"Inflammation and Regeneration"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"26540","DOI":"10.1074\/jbc.M203832200","article-title":"Detection of circulating and endothelial cell polymers of Z and wild type \u03b11-Antitrypsin by a monoclonal antibody","volume":"277","author":"Janciauskiene","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.rmed.2011.02.002","article-title":"The discovery of \u03b11-antitrypsin and its role in health and disease","volume":"105","author":"Janciauskiene","year":"2011","journal-title":"Respiratory Medicine"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"S280","DOI":"10.1513\/AnnalsATS.201507-468KV","article-title":"Well-Known and less Well-Known functions of Alpha-1 antitrypsin. Its role in chronic obstructive pulmonary disease and other disease developments","volume":"13 Suppl 4","author":"Janciauskiene","year":"2016","journal-title":"Annals of the American Thoracic Society"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S0076-6879(09)05218-5","article-title":"Analysis of chemokine receptor endocytosis and intracellular trafficking","volume":"460","author":"Kershaw","year":"2009","journal-title":"Methods in Enzymology"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1128\/IAI.64.5.1762-1769.1996","article-title":"Human monocyte CD14 is upregulated by lipopolysaccharide","volume":"64","author":"Landmann","year":"1996","journal-title":"Infection and Immunity"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1182\/blood-2008-07-170787","article-title":"CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival","volume":"113","author":"Landsman","year":"2009","journal-title":"Blood"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1172\/JCI0216782","article-title":"Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy","volume":"110","author":"Lomas","year":"2002","journal-title":"Journal of Clinical Investigation"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1002\/hep.23760","article-title":"A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency","volume":"52","author":"Miranda","year":"2010","journal-title":"Hepatology"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1021\/bi9820614","article-title":"Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1","volume":"38","author":"Mizoue","year":"1999","journal-title":"Biochemistry"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"14895","DOI":"10.1073\/pnas.0401168101","article-title":"Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease","volume":"101","author":"Ning","year":"2004","journal-title":"PNAS"},{"key":"bib32","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-65988-w","article-title":"CX3CL1 homo-oligomerization drives cell-to-cell adherence","volume":"10","author":"Ostuni","year":"2020","journal-title":"Scientific Reports"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"6421","DOI":"10.4049\/jimmunol.180.9.6421","article-title":"Decreased expression of the fractalkine receptor CX3CR1 on circulating monocytes as new feature of sepsis-induced immunosuppression","volume":"180","author":"Pachot","year":"2008","journal-title":"The Journal of Immunology"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1165\/ajrcmb.26.6.4739","article-title":"Polymers of alpha(1)-antitrypsin are chemotactic for human neutrophils: a new paradigm for the pathogenesis of emphysema","volume":"26","author":"Parmar","year":"2002","journal-title":"American journal of respiratory cell and molecular biology"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1073\/pnas.0334864100","article-title":"Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines","volume":"100","author":"Proudfoot","year":"2003","journal-title":"PNAS"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1111\/j.1365-2567.2009.03181.x","article-title":"Interleukin-10 and interferon-gamma modulate surface expression of fractalkine-receptor (CX(3)CR1) via PI3K in monocytes","volume":"129","author":"Ramos","year":"2010","journal-title":"Immunology"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.immuni.2009.09.010","article-title":"Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology","volume":"31","author":"Ransohoff","year":"2009","journal-title":"Immunity"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1136\/thoraxjnl-2012-202212","article-title":"Critical role of fractalkine (CX3CL1) in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium","volume":"68","author":"Rius","year":"2013","journal-title":"Thorax"},{"key":"bib39","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-9-34","article-title":"Endotoxin receptor CD14 in PiZ alpha-1-antitrypsin deficiency individuals","volume":"9","author":"Sandstr\u00f6m","year":"2008","journal-title":"Respiratory Research"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.cellimm.2004.10.001","article-title":"IL-15 alters expression and function of the chemokine receptor CX3CR1 in human NK cells","volume":"230","author":"Sechler","year":"2004","journal-title":"Cellular Immunology"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1084\/jem.185.5.969","article-title":"Bacterial lipopolysaccharide rapidly inhibits expression of C-C chemokine receptors in human monocytes","volume":"185","author":"Sica","year":"1997","journal-title":"Journal of Experimental Medicine"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/0092-8674(94)90337-9","article-title":"Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm","volume":"76","author":"Springer","year":"1994","journal-title":"Cell"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.rmed.2019.02.001","article-title":"Blood monocyte profiles in COPD patients with PiMM and PiZZ \u03b11-antitrypsin","volume":"148","author":"Stolk","year":"2019","journal-title":"Respiratory Medicine"},{"key":"bib44","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1056\/NEJMra1910234","article-title":"Alpha1-Antitrypsin Deficiency","volume":"382","author":"Strnad","year":"2020","journal-title":"The New England journal of medicine"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1183\/09031936.00111213","article-title":"Circulating polymers in \u03b11-antitrypsin deficiency","volume":"43","author":"Tan","year":"2014","journal-title":"European Respiratory Journal"},{"key":"bib46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140566","article-title":"Fractalkine Signaling Regulates the Inflammatory Response in an \u03b1-Synuclein Model of Parkinson Disease","volume":"10","author":"Thome","year":"2015","journal-title":"PLOS ONE"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1161\/01.ATV.0000095360.62479.1F","article-title":"Fractalkine in vascular biology: from basic research to clinical disease","volume":"24","author":"Umehara","year":"2004","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.1161\/ATVBAHA.114.304717","article-title":"Fractalkine promotes human monocyte survival via a reduction in oxidative stress","volume":"34","author":"White","year":"2014","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"bib49","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01828-y","article-title":"Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice","volume":"17","author":"Winter","year":"2020","journal-title":"Journal of Neuroinflammation"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1182\/blood-2010-02-258558","article-title":"Nomenclature of monocytes and dendritic cells in blood","volume":"116","author":"Ziegler-Heitbrock","year":"2010","journal-title":"Blood"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/64881\/elife-64881-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/64881\/elife-64881-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/64881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:07:29Z","timestamp":1697058449000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/64881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,18]]},"references-count":50,"alternative-id":["10.7554\/eLife.64881"],"URL":"https:\/\/doi.org\/10.7554\/elife.64881","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.11.24.395640","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.64881.sa2","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.64881.sa1","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,18]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e64881"}}