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In Cnidaria, the frequency of appendage regeneration in the moon jellyfish\n                    <jats:italic>Aurelia<\/jats:italic>\n                    was increased by feeding with the amino acid L-leucine and the growth hormone insulin. In insects, the same strategy induced tibia regeneration in adult\n                    <jats:italic>Drosophila<\/jats:italic>\n                    . Finally, in mammals, L-leucine and sucrose administration induced digit regeneration in adult mice, including dramatically from mid-phalangeal amputation. The conserved effect of L-leucine and insulin\/sugar suggests a key role for energetic parameters in regeneration induction. The simplicity by which nutrient supplementation can induce appendage regeneration provides a testable hypothesis across animals.\n                  <\/jats:p>","DOI":"10.7554\/elife.65092","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T08:15:16Z","timestamp":1637741716000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.65092","source":"Crossref","is-referenced-by-count":30,"title":["A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice"],"prefix":"10.7554","volume":"10","author":[{"given":"Michael J","family":"Abrams","sequence":"first","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology","place":["Pasadena, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fayth Hui","family":"Tan","sequence":"first","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology","place":["Pasadena, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8151-3518","authenticated-orcid":true,"given":"Yutian","family":"Li","sequence":"first","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology","place":["Pasadena, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ty","family":"Basinger","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology","place":["Pasadena, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin L","family":"Heithe","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology","place":["Pasadena, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anish","family":"Sarma","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology","place":["Pasadena, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris T","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology","place":["Pasadena, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zevin J","family":"Condiotte","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology","place":["Pasadena, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misha","family":"Raffiee","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology","place":["Pasadena, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John O","family":"Dabiri","sequence":"additional","affiliation":[{"name":"Graduate Aerospace Laboratories and Mechanical Engineering, California Institute of Technology","place":["Pasadena, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Gold","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology","place":["Pasadena, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3904-0195","authenticated-orcid":true,"given":"Lea","family":"Goentoro","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering, California Institute of Technology","place":["Pasadena, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"E3365","DOI":"10.1073\/pnas.1502497112","article-title":"Self-repairing symmetry in jellyfish through mechanically driven reorganization","volume":"112","author":"Abrams","year":"2015","journal-title":"PNAS"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16346-w","article-title":"Food availability drives plastic self-repair response in a basal metazoan- case study on the ctenophore Mnemiopsis leidyi A. 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