{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:04:25Z","timestamp":1789589065026,"version":"build-2803163510"},"reference-count":31,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Strategic Priority Research Program of the Chinese Academy of Sciences","award":["XDA16040302"],"award-info":[{"award-number":["XDA16040302"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971336"],"award-info":[{"award-number":["81971336"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771526"],"award-info":[{"award-number":["81771526"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071600"],"award-info":[{"award-number":["82071600"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Excellent Youth Natural Science Foundation of Jiangsu Province","award":["BK20170051"],"award-info":[{"award-number":["BK20170051"]}]},{"name":"Jiangsu Province\u2019s Key Provincial Talents Program","award":["ZDRCA2016067"],"award-info":[{"award-number":["ZDRCA2016067"]}]},{"name":"Jiangsu Biobank of Clinical Resources","award":["BM2015004"],"award-info":[{"award-number":["BM2015004"]}]},{"name":"National Key R&D Program of China","award":["2018YFC1004404"],"award-info":[{"award-number":["2018YFC1004404"]}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Emerging evidence demonstrates the important role of circular RNAs (circRNAs) in regulating pathological processes in various diseases including organ fibrosis. Endometrium fibrosis is the leading cause of uterine infertility, but the role of circRNAs in its pathogenesis is largely unknown. Here, we provide the evidence that upregulation of circPTPN12 in endometrial epithelial cells (EECs) of fibrotic endometrium functions as endogenous sponge of miR-21\u20135 p to inhibit miR-21\u20135 p expression and activity, which in turn results in upregulation of \u0394Np63\u03b1 to induce the epithelial mesenchymal transition (EMT) of EECs (EEC\u2013EMT). In a mouse model of endometrium fibrosis, circPTPN12 appears to be a cofactor of driving EEC\u2013EMT and administration of\n                    <jats:italic>miR-21\u20135<\/jats:italic>\n                    p could reverse this process and improve endometrial fibrosis. Our findings revealed that the dysfunction of circPTPN12\/miR-21\u20135 p\/\u2206Np63\u03b1 pathway contributed to the pathogenesis of endometrial fibrosis.\n                  <\/jats:p>","DOI":"10.7554\/elife.65735","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T06:00:15Z","timestamp":1623823215000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.65735","source":"Crossref","is-referenced-by-count":39,"title":["circPTPN12\/miR-21\u20135 p\/\u2206Np63\u03b1 pathway contributes to human endometrial fibrosis"],"prefix":"10.7554","volume":"10","author":[{"given":"Minmin","family":"Song","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 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