{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:51:47Z","timestamp":1790650307084,"version":"4.1.0"},"reference-count":78,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"},{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"},{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM110628"],"award-info":[{"award-number":["GM110628"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK124115"],"award-info":[{"award-number":["DK124115"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Innate immune cellular effectors are actively consumed during systemic inflammation, but the systemic traffic and the mechanisms that support their replenishment remain unknown. Here, we demonstrate that acute systemic inflammation induces the emergent activation of a previously unrecognized system of rapid migration of granulocyte-macrophage progenitors and committed macrophage-dendritic progenitors, but not other progenitors or stem cells, from bone marrow (BM) to regional lymphatic capillaries. The progenitor traffic to the systemic lymphatic circulation is mediated by Ccl19\/Ccr7 and is NF-\u03baB independent, Traf6\/I\u03baB-kinase\/SNAP23 activation dependent, and is responsible for the secretion of pre-stored Ccl19 by a subpopulation of CD205\n                    <jats:sup>+<\/jats:sup>\n                    \/CD172a\n                    <jats:sup>+<\/jats:sup>\n                    conventional dendritic cells type 2 and upregulation of BM myeloid progenitor Ccr7 signaling. Mature myeloid Traf6 signaling is anti-inflammatory and necessary for lymph node myeloid cell development. This report unveils the existence and the mechanistic basis of a very early direct traffic of myeloid progenitors from BM to lymphatics during inflammation.\n                  <\/jats:p>","DOI":"10.7554\/elife.66190","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T08:06:15Z","timestamp":1617869175000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.66190","source":"Crossref","is-referenced-by-count":6,"title":["Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics"],"prefix":"10.7554","volume":"10","author":[{"given":"Juana","family":"Serrano-Lopez","sequence":"first","affiliation":[{"name":"Divisions of Experimental Hematology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailaja","family":"Hegde","sequence":"additional","affiliation":[{"name":"Divisions of Experimental Hematology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States"},{"name":"Hoxworth Blood Center, University of Cincinnati College of Medicine, Cincinnati, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Kumar","sequence":"additional","affiliation":[{"name":"Divisions of Experimental Hematology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Serrano","sequence":"additional","affiliation":[{"name":"Hematology Department, Reina Sof\u00eda University Hospital\/Maimonides Biomedical Research Institute of C\u00f3rdoba (IMIBIC)\/University of C\u00f3rdoba, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fang","sequence":"additional","affiliation":[{"name":"Divisions of Experimental Hematology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley M","family":"Wellendorf","sequence":"additional","affiliation":[{"name":"Divisions of Experimental Hematology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A","family":"Roche","sequence":"additional","affiliation":[{"name":"Center for Cancer Research, National Cancer Institute, Bethesda, United States"},{"name":"Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamileth","family":"Rangel","sequence":"additional","affiliation":[{"name":"Hematology Department, Reina Sof\u00eda University Hospital\/Maimonides Biomedical Research Institute of C\u00f3rdoba (IMIBIC)\/University of C\u00f3rdoba, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-3270","authenticated-orcid":true,"given":"Leolene J","family":"Carrington","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine, Philadelphia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5794-5430","authenticated-orcid":true,"given":"Hartmut","family":"Geiger","sequence":"additional","affiliation":[{"name":"Divisions of Experimental Hematology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States"},{"name":"Institute of Molecular Medicine, Ulm University, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Leighton","family":"Grimes","sequence":"additional","affiliation":[{"name":"Immunobiology, Department of Pediatrics, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv","family":"Luther","sequence":"additional","affiliation":[{"name":"Center for Immunity and Infection, Department of Biochemistry, University of Lausanne, Epalinges, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Maillard","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine, Philadelphia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Sanchez-Garcia","sequence":"additional","affiliation":[{"name":"Hematology Department, Reina Sof\u00eda University Hospital\/Maimonides Biomedical Research Institute of C\u00f3rdoba (IMIBIC)\/University of C\u00f3rdoba, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T","family":"Starczynowski","sequence":"additional","affiliation":[{"name":"Divisions of Experimental Hematology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States"},{"name":"Department of Cancer Biology, University of Cincinnati, Cincinnati, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1291-7233","authenticated-orcid":true,"given":"Jose A","family":"Cancelas","sequence":"additional","affiliation":[{"name":"Divisions of Experimental Hematology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States"},{"name":"Hoxworth Blood Center, University of Cincinnati College of Medicine, Cincinnati, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"Akira","year":"2001","journal-title":"Nature Immunology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"9897","DOI":"10.1073\/pnas.1120636110","article-title":"Circadian clock regulates the host response to Salmonella","volume":"110","author":"Bellet","year":"2013","journal-title":"PNAS"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/nri1004","article-title":"Innate immune sensing and its roots: the story of endotoxin","volume":"3","author":"Beutler","year":"2003","journal-title":"Nature Reviews Immunology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"5824","DOI":"10.4049\/jimmunol.1103253","article-title":"Cutting edge: lps-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells","volume":"188","author":"Boettcher","year":"2012","journal-title":"The Journal of Immunology"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1002\/ajh.2830160309","article-title":"The total marrow mass of the mouse: a simplified method of measurement","volume":"16","author":"Boggs","year":"1984","journal-title":"American Journal of Hematology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/sj.leu.2403563","article-title":"Rapid reconstitution of dendritic cells after allogeneic transplantation of CD133+ selected hematopoietic stem cells","volume":"19","author":"Bornh\u00e4user","year":"2005","journal-title":"Leukemia"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1084\/jem.20141441","article-title":"Circulating precursors of human CD1c+ and CD141+ dendritic cells","volume":"212","author":"Breton","year":"2015","journal-title":"Journal of Experimental Medicine"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.mad.2010.10.002","article-title":"Human blood and marrow side population stem cell and Stro-1 positive bone marrow stromal cell numbers decline with age, with an increase in quality of surviving stem cells: correlation with cytokines","volume":"131","author":"Brusnahan","year":"2010","journal-title":"Mechanisms of Ageing and Development"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"5019","DOI":"10.1182\/blood-2011-01-293050","article-title":"The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications","volume":"117","author":"Campo","year":"2011","journal-title":"Blood"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/nm1274","article-title":"Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization","volume":"11","author":"Cancelas","year":"2005","journal-title":"Nature Medicine"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.cell.2013.04.040","article-title":"Rhythmic modulation of the hematopoietic niche through neutrophil clearance","volume":"153","author":"Casanova-Acebes","year":"2013","journal-title":"Cell"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1634\/stemcells.2005-0116","article-title":"A side order of stem cells: the SP phenotype","volume":"24","author":"Challen","year":"2006","journal-title":"Stem Cells"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1016\/j.celrep.2014.11.031","article-title":"p62 is required for stem cell\/progenitor retention through inhibition of IKK\/NF-\u03baB\/Ccl4 signaling at the bone marrow macrophage-osteoblast niche","volume":"9","author":"Chang","year":"2014","journal-title":"Cell Reports"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1038\/s41590-019-0402-5","article-title":"Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation","volume":"20","author":"Chavakis","year":"2019","journal-title":"Nature Immunology"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.cell.2010.09.039","article-title":"Microbial stimulation fully differentiates monocytes to DC-SIGN\/CD209(+) dendritic cells for immune T cell Areas","volume":"143","author":"Cheong","year":"2010","journal-title":"Cell"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1023\/a:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"Clausen","year":"1999","journal-title":"Transgenic Research"},{"key":"bib17","first-page":"186","article-title":"Mobilization of hematopoietic stem cells (CFU-C) into the peripheral blood of man by endotoxin","volume":"5","author":"Cline","year":"1977","journal-title":"Experimental Hematology"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"6232","DOI":"10.1073\/pnas.85.17.6232","article-title":"Mouse lysozyme M gene: isolation, characterization, and expression studies","volume":"85","author":"Cross","year":"1988","journal-title":"PNAS"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1172\/JCI40645","article-title":"Comprehensive assessment of chemokine expression profiles by flow cytometry","volume":"120","author":"Eberlein","year":"2010","journal-title":"Journal of Clinical Investigation"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"5367","DOI":"10.4049\/jimmunol.1003438","article-title":"Chronic exposure to a TLR ligand injures hematopoietic stem cells","volume":"186","author":"Esplin","year":"2011","journal-title":"The Journal of Immunology"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/ni.3654","article-title":"Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia","volume":"18","author":"Fang","year":"2017","journal-title":"Nature Immunology"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/j.celrep.2018.01.013","article-title":"TRAF6 mediates basal activation of NF-\u03baB necessary for hematopoietic stem cell homeostasis","volume":"22","author":"Fang","year":"2018","journal-title":"Cell Reports"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1126\/science.1117729","article-title":"A clonogenic bone marrow progenitor specific for macrophages and dendritic cells","volume":"311","author":"Fogg","year":"2006","journal-title":"Science"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0092-8674(00)80059-8","article-title":"CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs","volume":"99","author":"F\u00f6rster","year":"1999","journal-title":"Cell"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/nri2297","article-title":"CCR7 and its ligands: balancing immunity and tolerance","volume":"8","author":"F\u00f6rster","year":"2008","journal-title":"Nature Reviews Immunology"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","article-title":"Blood monocytes consist of two principal subsets with distinct migratory properties","volume":"19","author":"Geissmann","year":"2003","journal-title":"Immunity"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"5144","DOI":"10.1182\/blood-2011-07-368506","article-title":"Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors","volume":"119","author":"Gonzalez-Nieto","year":"2012","journal-title":"Blood"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1084\/jem.183.4.1797","article-title":"Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo","volume":"183","author":"Goodell","year":"1996","journal-title":"Journal of Experimental Medicine"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1016\/j.celrep.2013.04.025","article-title":"Revision of the human hematopoietic tree: granulocyte subtypes derive from distinct hematopoietic lineages","volume":"3","author":"G\u00f6rgens","year":"2013","journal-title":"Cell Reports"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nature11926","article-title":"CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance","volume":"495","author":"Greenbaum","year":"2013","journal-title":"Nature"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/s42255-018-0016-5","article-title":"A network of trans-cortical capillaries as mainstay for blood circulation in long bones","volume":"1","author":"Gr\u00fcneboom","year":"2019","journal-title":"Nature Metabolism"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1677\/JOE-08-0568","article-title":"Bone loss in inflammatory disorders","volume":"201","author":"Hardy","year":"2009","journal-title":"Journal of Endocrinology"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1182\/blood.V55.1.77.77","article-title":"Competitive repopulation: a new assay for long-term stem cell functional capacity","volume":"55","author":"Harrison","year":"1980","journal-title":"Blood"},{"key":"bib34","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34323","article-title":"VEGF-C promotes the development of lymphatics in bone and bone loss","volume":"7","author":"Hominick","year":"2018","journal-title":"eLife"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"4106","DOI":"10.1128\/MCB.20.11.4106-4114.2000","article-title":"Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion","volume":"20","author":"Jung","year":"2000","journal-title":"Molecular and Cellular Biology"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/S1471-4906(00)01811-1","article-title":"Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice","volume":"22","author":"Kaisho","year":"2001","journal-title":"Trends in Immunology"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1182\/blood.V100.5.1734.h81702001734_1734_1741","article-title":"Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs","volume":"100","author":"Kamath","year":"2002","journal-title":"Blood"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"4567","DOI":"10.1182\/blood-2012-11-470468","article-title":"I\u03bab kinase phosphorylation of SNAP-23 controls platelet secretion","volume":"121","author":"Karim","year":"2013","journal-title":"Blood"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nri1703","article-title":"NF-kappaB: linking inflammation and immunity to Cancer development and progression","volume":"5","author":"Karin","year":"2005","journal-title":"Nature Reviews Immunology"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/sj.cdd.4401850","article-title":"TLR signaling","volume":"13","author":"Kawai","year":"2006","journal-title":"Cell Death & Differentiation"},{"key":"bib41","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.4049\/jimmunol.161.5.2580","article-title":"Macrophage-inflammatory protein-3 beta\/EBI1-ligand chemokine\/CK beta-11, a CC chemokine, is a chemoattractant with a specificity for macrophage progenitors among myeloid progenitor cells","volume":"161","author":"Kim","year":"1998","journal-title":"Journal of Immunology"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S1074-7613(03)00230-9","article-title":"TRAF6 is a critical factor for dendritic cell maturation and development","volume":"19","author":"Kobayashi","year":"2003","journal-title":"Immunity"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1182\/blood-2008-12-195644","article-title":"Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones","volume":"114","author":"K\u00f6hler","year":"2009","journal-title":"Blood"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.immuni.2014.12.017","article-title":"Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis","volume":"42","author":"Kwak","year":"2015","journal-title":"Immunity"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1084\/jem.187.4.655","article-title":"B Cell\u2013attracting Chemokine 1, a Human CXC Chemokine Expressed in Lymphoid Tissues, Selectively Attracts B Lymphocytes via BLR1\/CXCR5","volume":"187","author":"Legler","year":"1998","journal-title":"Journal of Experimental Medicine"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1038\/ni1513","article-title":"Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells","volume":"8","author":"Link","year":"2007","journal-title":"Nature Immunology"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"12694","DOI":"10.1073\/pnas.97.23.12694","article-title":"Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt\/plt mouse","volume":"97","author":"Luther","year":"2000","journal-title":"PNAS"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1056\/NEJMoa022139","article-title":"The epidemiology of Sepsis in the united states from 1979 through 2000","volume":"348","author":"Martin","year":"2003","journal-title":"New England Journal of Medicine"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.cell.2007.09.047","article-title":"Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues","volume":"131","author":"Massberg","year":"2007","journal-title":"Cell"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S1074-7613(03)00354-6","article-title":"Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells","volume":"20","author":"Matsuzaki","year":"2004","journal-title":"Immunity"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/nature06685","article-title":"Haematopoietic stem cell release is regulated by circadian oscillations","volume":"452","author":"M\u00e9ndez-Ferrer","year":"2008","journal-title":"Nature"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/nature09262","article-title":"Mesenchymal and haematopoietic stem cells form a unique bone marrow niche","volume":"466","author":"M\u00e9ndez-Ferrer","year":"2010","journal-title":"Nature"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/nature01345","article-title":"Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL\/tal-1 gene","volume":"421","author":"Mikkola","year":"2003","journal-title":"Nature"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.cell.2017.11.034","article-title":"Modulation of myelopoiesis progenitors is an integral component of trained immunity","volume":"172","author":"Mitroulis","year":"2018","journal-title":"Cell"},{"key":"bib55","doi-asserted-by":"publisher","DOI":"10.1242\/dev.184291","article-title":"Lymphatics in bone arise from pre-existing lymphatics","volume":"147","author":"Monroy","year":"2020","journal-title":"Development"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1084\/jem.193.2.207","article-title":"Mice lacking expression of the chemokines Ccl21-Ser and Ccl19 (plt mice) Demonstrate delayed but enhanced T cell immune responses","volume":"193","author":"Mori","year":"2001","journal-title":"Journal of Experimental Medicine"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.immuni.2006.04.008","article-title":"Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment","volume":"24","author":"Nagai","year":"2006","journal-title":"Immunity"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1177\/000348940911800512","article-title":"Radiographic and Micro\u2014Computed Tomographic Imaging of Lipopolysaccharide-Mediated Bone Resorption","volume":"118","author":"Nason","year":"2009","journal-title":"Annals of Otology, Rhinology & Laryngology"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/978-1-60761-421-0_12","article-title":"The generation of plasmacytoid and conventional dendritic cells with M-CSF","volume":"595","author":"O'Keeffe","year":"2010","journal-title":"Methods in Molecular Biology"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S0014-5793(97)00313-X","article-title":"'Green mice' as a source of ubiquitous green cells","volume":"407","author":"Okabe","year":"1997","journal-title":"FEBS Letters"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1084\/jem.20091619","article-title":"Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning","volume":"207","author":"Pham","year":"2010","journal-title":"Journal of Experimental Medicine"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.ccr.2013.05.006","article-title":"Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome","volume":"24","author":"Rhyasen","year":"2013","journal-title":"Cancer Cell"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1146\/annurev.immunol.21.090501.080131","article-title":"Ligands for L-selectin: homing, inflammation, and beyond","volume":"22","author":"Rosen","year":"2004","journal-title":"Annual Review of Immunology"},{"key":"bib64","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.4049\/jimmunol.162.5.2472","article-title":"Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes","volume":"162","author":"Saeki","year":"1999","journal-title":"Journal of Immunology"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1034\/j.1600-065X.2000.17717.x","article-title":"Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression","volume":"177","author":"Sallusto","year":"2000","journal-title":"Immunological Reviews"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"4829","DOI":"10.1182\/blood-2011-03-344960","article-title":"Bone marrow dendritic cell progenitors sense pathogens via Toll-like receptors and subsequently migrate to inflamed lymph nodes","volume":"118","author":"Schmid","year":"2011","journal-title":"Blood"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.cell.2008.05.050","article-title":"Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation","volume":"134","author":"Suzuki","year":"2008","journal-title":"Cell"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1084\/jem.20041419","article-title":"Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow","volume":"201","author":"Ueda","year":"2005","journal-title":"Journal of Experimental Medicine"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1182\/blood-2002-07-2270","article-title":"Reduced stem cell mobilization in mice receiving antibiotic modulation of the intestinal flora: involvement of endotoxins as cofactors in mobilization","volume":"103","author":"Velders","year":"2004","journal-title":"Blood"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/j.1365-2184.1972.tb00385.x","article-title":"Mobilization of haemopoietic stem cells (CFU) into the peripheral blood of the mouse; effects of endotoxin and other compounds","volume":"5","author":"Vos","year":"1972","journal-title":"Cell Proliferation"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1111\/j.1365-2184.1979.tb00148.x","article-title":"FURTHER STUDIES ON MOBILIZATION OF CFUs","volume":"12","author":"Vos","year":"1979","journal-title":"Cell Proliferation"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/ni.1615","article-title":"The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues","volume":"9","author":"Waskow","year":"2008","journal-title":"Nature Immunology"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"S88","DOI":"10.1038\/modpathol.2012.176","article-title":"Benign lymphadenopathies","volume":"26 Suppl 1","author":"Weiss","year":"2013","journal-title":"Modern Pathology"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1182\/blood-2007-09-115006","article-title":"CD150- side population cells represent a functionally distinct population of long-term hematopoietic stem cells","volume":"111","author":"Weksberg","year":"2008","journal-title":"Blood"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1126\/science.1064081","article-title":"Physiological migration of hematopoietic stem and progenitor cells","volume":"294","author":"Wright","year":"2001","journal-title":"Science"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.stem.2014.01.007","article-title":"Conversion of danger signals into cytokine signals by hematopoietic stem and progenitor cells for regulation of stress-induced hematopoiesis","volume":"14","author":"Zhao","year":"2014","journal-title":"Cell Stem Cell"},{"key":"bib78","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/nm0901-1028","article-title":"The ABC transporter Bcrp1\/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype","volume":"7","author":"Zhou","year":"2001","journal-title":"Nature Medicine"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/66190\/elife-66190-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/66190\/elife-66190-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/66190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T16:58:42Z","timestamp":1698857922000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/66190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,8]]},"references-count":78,"alternative-id":["10.7554\/eLife.66190"],"URL":"https:\/\/doi.org\/10.7554\/elife.66190","archive":["CLOCKSS"],"relation":{"has-review":[{"id-type":"doi","id":"10.7554\/eLife.66190.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.66190.sa2","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,8]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e66190"}}