{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:59:28Z","timestamp":1787032768738,"version":"build-2736575974"},"reference-count":75,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["K99EY030951"],"award-info":[{"award-number":["K99EY030951"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["U01EY025497"],"award-info":[{"award-number":["U01EY025497"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007817","name":"Alcon Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007817","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Astellas Pharmaceuticals"},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Retinitis pigmentosa (RP) is an inherited retinal disease affecting &gt;20 million people worldwide. Loss of daylight vision typically occurs due to the dysfunction\/loss of cone photoreceptors, the cell type that initiates our color and high-acuity vision. Currently, there is no effective treatment for RP, other than gene therapy for a limited number of specific disease genes. To develop a disease gene-agnostic therapy, we screened 20 genes for their ability to prolong cone photoreceptor survival in vivo. Here, we report an adeno-associated virus vector expressing Txnip, which prolongs the survival of cone photoreceptors and improves visual acuity in RP mouse models. A\n                    <jats:italic>Txnip<\/jats:italic>\n                    allele, C247S, which blocks the association of Txnip with thioredoxin, provides an even greater benefit. Additionally, the rescue effect of Txnip depends on lactate dehydrogenase b (Ldhb) and correlates with the presence of healthier mitochondria, suggesting that Txnip saves RP cones by enhancing their lactate catabolism.\n                  <\/jats:p>","DOI":"10.7554\/elife.66240","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T20:00:52Z","timestamp":1618257652000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.66240","source":"Crossref","is-referenced-by-count":50,"title":["AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2088-9826","authenticated-orcid":true,"given":"Yunlu","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States"},{"name":"Department of Ophthalmology, Harvard Medical School, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean K","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States"},{"name":"Department of Ophthalmology, Harvard Medical School, Boston, United States"},{"name":"Howard Hughs Medical Institute, Chevy Chase, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parimal","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma R","family":"West","sequence":"additional","affiliation":[{"name":"Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States"},{"name":"Howard Hughs Medical Institute, Chevy Chase, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christin M","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States"},{"name":"Howard Hughs Medical Institute, Chevy Chase, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helian","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States"},{"name":"Department of Ophthalmology, Harvard Medical School, Boston, United States"},{"name":"Retina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9945-6387","authenticated-orcid":true,"given":"Constance L","family":"Cepko","sequence":"additional","affiliation":[{"name":"Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States"},{"name":"Department of Ophthalmology, Harvard Medical School, Boston, United States"},{"name":"Howard Hughs Medical Institute, Chevy Chase, United 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