{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:17:53Z","timestamp":1785428273227,"version":"3.56.0"},"reference-count":38,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51772144"],"award-info":[{"award-number":["51772144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Science and Technology Development Foundation, Nanjing Department of Health","award":["YKK20152"],"award-info":[{"award-number":["YKK20152"]}]},{"name":"Nanjing Clinical Research Center for Oral Diseases, Nanjing Department of Health","award":["2019060009"],"award-info":[{"award-number":["2019060009"]}]},{"name":"Jiangsu Province Natural Science Foundation of China","award":["BK20200149"],"award-info":[{"award-number":["BK20200149"]}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2022,2,9]]},"abstract":"<jats:p>\n                    Hereditary gingival fibromatosis (HGF) is the most common genetic form of gingival fibromatosis which is featured as a localized or generalized overgrowth of gingivae. Currently two genes (\n                    <jats:italic>SOS1<\/jats:italic>\n                    and\n                    <jats:italic>REST<\/jats:italic>\n                    ), as well as four loci (2p22.1, 2p23.3\u2013p22.3, 5q13\u2013q22, and 11p15), have been identified as associated with HGF in a dominant inheritance pattern. Here, we report 13 individuals with autosomal-dominant HGF from a four-generation Chinese family. Whole-exome sequencing followed by further genetic co-segregation analysis was performed for the family members across three generations. A novel heterozygous missense mutation (c.2812G &gt; A) in zinc finger protein 862 gene (\n                    <jats:italic>ZNF862<\/jats:italic>\n                    ) was identified, and it is absent among the population as per the Genome Aggregation Database. The functional study supports a biological role of\n                    <jats:italic>ZNF862<\/jats:italic>\n                    for increasing the profibrotic factors particularly COL1A1 synthesis and hence resulting in HGF. Here, for the first time we identify the physiological role of\n                    <jats:italic>ZNF862<\/jats:italic>\n                    for the association with the HGF.\n                  <\/jats:p>","DOI":"10.7554\/elife.66646","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T08:00:19Z","timestamp":1644480019000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.66646","source":"Crossref","is-referenced-by-count":15,"title":["A novel gene ZNF862 causes hereditary gingival fibromatosis"],"prefix":"10.7554","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4494-6570","authenticated-orcid":true,"given":"Juan","family":"Wu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01rxvg760","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University","place":["Nanjing, 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huishuang","family":"Chen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/045pn2j94","id-type":"ROR","asserted-by":"publisher"}],"name":"BGI Genomics, BGI-Shenzhen","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Zhao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01rxvg760","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/045pn2j94","id-type":"ROR","asserted-by":"publisher"}],"name":"BGI Genomics, BGI-Shenzhen","place":["Shenzhen, 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Ren","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01rxvg760","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Zhai","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/045pn2j94","id-type":"ROR","asserted-by":"publisher"}],"name":"BGI Genomics, BGI-Shenzhen","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibin","family":"Sun","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01rxvg760","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University","place":["Nanjing, 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