{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:44:31Z","timestamp":1790837071766,"version":"4.1.0"},"reference-count":52,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BA 1742\/8-1"],"award-info":[{"award-number":["BA 1742\/8-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Immature neutrophils and HLA-DR\n                    <jats:sup>neg\/low<\/jats:sup>\n                    monocytes expand in cancer, autoimmune diseases and viral infections, but their appearance and immunoregulatory effects on T-cells after acute myocardial infarction (AMI) remain underexplored. We found an expansion of circulating immature CD16\n                    <jats:sup>+<\/jats:sup>\n                    CD66b\n                    <jats:sup>+<\/jats:sup>\n                    CD10\n                    <jats:sup>neg<\/jats:sup>\n                    neutrophils and CD14\n                    <jats:sup>+<\/jats:sup>\n                    HLA-DR\n                    <jats:sup>neg\/low<\/jats:sup>\n                    monocytes in AMI patients, correlating with cardiac damage, function and levels of immune-inflammation markers. Immature CD10\n                    <jats:sup>neg<\/jats:sup>\n                    neutrophils expressed high amounts of MMP-9 and S100A9, and displayed resistance to apoptosis. Moreover, we found that increased frequency of CD10\n                    <jats:sup>neg<\/jats:sup>\n                    neutrophils and elevated circulating IFN-\u03b3 levels were linked, mainly in patients with expanded CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD28\n                    <jats:sup>null<\/jats:sup>\n                    T-cells. Notably, the expansion of circulating CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD28\n                    <jats:sup>null<\/jats:sup>\n                    T-cells was associated with cytomegalovirus (CMV) seropositivity. Using bioinformatic tools, we identified a tight relationship among the peripheral expansion of immature CD10\n                    <jats:sup>neg<\/jats:sup>\n                    neutrophils, CMV IgG titers, and circulating levels of IFN-\u03b3 and IL-12 in patients with AMI. At a mechanistic level, CD10\n                    <jats:sup>neg<\/jats:sup>\n                    neutrophils enhanced IFN-\u03b3 production by CD4\n                    <jats:sup>+<\/jats:sup>\n                    T-cells through a contact-independent mechanism involving IL-12. In vitro experiments also highlighted that HLA-DR\n                    <jats:sup>neg\/low<\/jats:sup>\n                    monocytes do not suppress T-cell proliferation but secrete high levels of pro-inflammatory cytokines after differentiation to macrophages and IFN-\u03b3 stimulation. Lastly, using a mouse model of AMI, we showed that immature neutrophils (CD11b\n                    <jats:sup>pos<\/jats:sup>\n                    Ly6G\n                    <jats:sup>pos<\/jats:sup>\n                    CD101\n                    <jats:sup>neg<\/jats:sup>\n                    cells) are recruited to the injured myocardium and migrate to mediastinal lymph nodes shortly after reperfusion. In conclusion, immunoregulatory functions of CD10\n                    <jats:sup>neg<\/jats:sup>\n                    neutrophils play a dynamic role in mechanisms linking myeloid cell compartment dysregulation, Th1-type immune responses and inflammation after AMI.\n                  <\/jats:p>","DOI":"10.7554\/elife.66808","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T05:00:12Z","timestamp":1626930012000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.66808","source":"Crossref","is-referenced-by-count":54,"title":["Expansion of CD10neg neutrophils and CD14+HLA-DRneg\/low monocytes driving proinflammatory responses in patients with acute myocardial infarction"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7756-6032","authenticated-orcid":true,"given":"Daniela","family":"Fraccarollo","sequence":"first","affiliation":[{"name":"Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Neuser","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1818-6782","authenticated-orcid":true,"given":"Julian","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Riehle","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Galuppo","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Bauersachs","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1161\/CIRCRESAHA.120.315937","article-title":"Interleukin-1 and the inflammasome as therapeutic targets in cardiovascular disease","volume":"126","author":"Abbate","year":"2020","journal-title":"Circulation Research"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1038\/s41591-018-0059-x","article-title":"The human heart contains distinct macrophage subsets with divergent origins and functions","volume":"24","author":"Bajpai","year":"2018","journal-title":"Nature Medicine"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17772-7","article-title":"A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis","volume":"11","author":"Barth","year":"2020","journal-title":"Nature Communications"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1093\/eurheartj\/ehy128","article-title":"Interleukin-1 blockade in cardiovascular diseases: a clinical update","volume":"39","author":"Buckley","year":"2018","journal-title":"European Heart Journal"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115828","article-title":"S100A9 induced inflammatory responses are mediated by distinct damage associated molecular patterns (DAMP) receptors in vitro and in vivo","volume":"10","author":"Chen","year":"2015","journal-title":"PLOS ONE"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/imm.13005","article-title":"Recent advances on the crosstalk between neutrophils and B or T lymphocytes","volume":"156","author":"Costa","year":"2019","journal-title":"Immunology"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s41577-020-0332-3","article-title":"Building a T cell compartment: how immune cell development shapes function","volume":"20","author":"Davenport","year":"2020","journal-title":"Nature Reviews Immunology"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1016\/j.cell.2020.08.001","article-title":"Severe COVID-19 is marked by a dysregulated myeloid cell compartment","volume":"182","author":"Deutsche COVID-19 OMICS Initiative (DeCOI)","year":"2020","journal-title":"Cell"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/cvr\/cvn248","article-title":"CD4+ CD28 null T cells in coronary artery disease: when helpers become killers","volume":"81","author":"Dumitriu","year":"2009","journal-title":"Cardiovascular Research"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.4049\/jimmunol.1601520","article-title":"Efferocytosis signaling in the regulation of macrophage inflammatory responses","volume":"198","author":"Elliott","year":"2017","journal-title":"The Journal of Immunology"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.immuni.2018.02.002","article-title":"Developmental analysis of bone marrow neutrophils reveals populations specialized in expansion, trafficking, and effector functions","volume":"48","author":"Evrard","year":"2018","journal-title":"Immunity"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1161\/CIRCULATIONAHA.110.983023","article-title":"Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction","volume":"123","author":"Fraccarollo","year":"2011","journal-title":"Circulation"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/978-1-4939-7113-8_9","article-title":"Modeling cardiac fibrosis in mice: (Myo)Fibroblast phenotype after ischemia","volume":"1627","author":"Fraccarollo","year":"2017","journal-title":"Methods in Molecular Biology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1161\/HYPERTENSIONAHA.118.12162","article-title":"Macrophage mineralocorticoid receptor is a pleiotropic modulator of myocardial infarct healing","volume":"73","author":"Fraccarollo","year":"2019","journal-title":"Hypertension"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nature Reviews Immunology"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"5122","DOI":"10.1096\/fj.201700317R","article-title":"The glucocorticoid receptor in monocyte-derived macrophages is critical for cardiac infarct repair and remodeling","volume":"31","author":"Galuppo","year":"2017","journal-title":"The FASEB Journal"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.ijcard.2010.10.053","article-title":"Immune responses after acute ischemic stroke or myocardial infarction","volume":"155","author":"Haeusler","year":"2012","journal-title":"International Journal of Cardiology"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1161\/ATVBAHA.118.311023","article-title":"Gut Microbiota-Dependent trimethylamine N-Oxide predicts risk of cardiovascular events in patients with stroke and is related to proinflammatory monocytes","volume":"38","author":"Haghikia","year":"2018","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"bib19","doi-asserted-by":"publisher","DOI":"10.1101\/2020.06.17.156588","article-title":"Ultra-pure isolation of low density neutrophils casts doubt on their exceptionality in health and disease","volume":"2057","author":"Hardisty","year":"2021","journal-title":"Frontiers in Immunology"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1093\/eurheartj\/ehw224","article-title":"The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge","volume":"38","author":"Heusch","year":"2017","journal-title":"European Heart Journal"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1161\/CIRCRESAHA.116.304393","article-title":"Myocardial ischemia and reperfusion leads to transient CD8 immune deficiency and accelerated immunosenescence in CMV-seropositive patients","volume":"116","author":"Hoffmann","year":"2015","journal-title":"Circulation Research"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1093\/eurheartj\/ehw002","article-title":"Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype","volume":"38","author":"Horckmans","year":"2017","journal-title":"European Heart Journal"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1002\/eji.1830250308","article-title":"The distribution of CD10 (NEP 24.11, CALLA) in humans and mice is similar in non-lymphoid organs but differs within the hematopoietic system: absence on murine T and B lymphoid progenitors","volume":"25","author":"Kalled","year":"1995","journal-title":"European Journal of Immunology"},{"key":"bib24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000461","article-title":"Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis","volume":"5","author":"Koedel","year":"2009","journal-title":"PLOS Pathogens"},{"key":"bib25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00471","article-title":"How neutrophils shape adaptive immune responses","volume":"6","author":"Leliefeld","year":"2015","journal-title":"Frontiers in Immunology"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"19083","DOI":"10.1073\/pnas.1905054116","article-title":"Phenotypically distinct neutrophils patrol uninfected human and mouse lymph nodes","volume":"116","author":"Lok","year":"2019","journal-title":"PNAS"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1006\/clim.1998.4638","article-title":"Role of Cytomegalovirus in the T cell changes seen in elderly individuals","volume":"90","author":"Looney","year":"1999","journal-title":"Clinical Immunology"},{"key":"bib28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01912","article-title":"Neutrophil maturity in cancer","volume":"10","author":"Mackey","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"bib29","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9051602","article-title":"Neutrophil phenotypes in coronary artery disease","volume":"9","author":"Mar\u00e9chal","year":"2020","journal-title":"Journal of Clinical Medicine"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1182\/blood-2016-04-713206","article-title":"Mature CD10+ and immature CD10- neutrophils present in G-CSF-treated donors display opposite effects on T cells","volume":"129","author":"Marini","year":"2017","journal-title":"Blood"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","article-title":"Of mice and not men: differences between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"The Journal of Immunology"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.clim.2018.03.015","article-title":"More intensive CMV-infection in chronic heart failure patients contributes to higher T-lymphocyte differentiation degree","volume":"192","author":"Moro-Garc\u00eda","year":"2018","journal-title":"Clinical Immunology"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"bib34","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21450-6","article-title":"Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms","volume":"8","author":"Negorev","year":"2018","journal-title":"Scientific Reports"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1038\/nri2318","article-title":"Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections","volume":"8","author":"Nikolich-Zugich","year":"2008","journal-title":"Nature Reviews Immunology"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"4509","DOI":"10.7150\/thno.27428","article-title":"CD28null pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death","volume":"8","author":"Pera","year":"2018","journal-title":"Theranostics"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1136\/annrheumdis-2018-214620","article-title":"Low-density granulocytes activate T cells and demonstrate a non-suppressive role in systemic lupus erythematosus","volume":"78","author":"Rahman","year":"2019","journal-title":"Annals of the Rheumatic Diseases"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1093\/cvr\/cvz161","article-title":"Small animal models of heart failure","volume":"115","author":"Riehle","year":"2019","journal-title":"Cardiovascular Research"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"4838","DOI":"10.4049\/jimmunol.1300725","article-title":"IL-1 induces proinflammatory leukocyte infiltration and regulates fibroblast phenotype in the infarcted myocardium","volume":"191","author":"Saxena","year":"2013","journal-title":"The Journal of Immunology"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.it.2019.04.012","article-title":"Neutrophil diversity in health and disease","volume":"40","author":"Silvestre-Roig","year":"2019","journal-title":"Trends in Immunology"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/s41569-019-0326-7","article-title":"Neutrophils as regulators of cardiovascular inflammation","volume":"17","author":"Silvestre-Roig","year":"2020","journal-title":"Nature Reviews Cardiology"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.cell.2020.08.002","article-title":"Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19","volume":"182","author":"Silvin","year":"2020","journal-title":"Cell"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1161\/CIRCULATIONAHA.119.043833","article-title":"Neutrophil-Derived S100A8\/A9 amplify granulopoiesis after myocardial infarction","volume":"141","author":"Sreejit","year":"2020","journal-title":"Circulation"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1161\/ATVBAHA.119.313032","article-title":"Low levels of CD4+CD28null T cells at Baseline are associated with First-Time coronary events in a prospective Population-Based Case-Control cohort","volume":"40","author":"Tomas","year":"2020","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1161\/CIRCRESAHA.119.315454","article-title":"G-CSF's Last Stand in STEMI","volume":"125","author":"Traverse","year":"2019","journal-title":"Circulation Research"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nri1001","article-title":"Interleukin-12 and the regulation of innate resistance and adaptive immunity","volume":"3","author":"Trinchieri","year":"2003","journal-title":"Nature Reviews Immunology"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"207","DOI":"10.4049\/jimmunol.1801255","article-title":"Immature neutrophils released in acute inflammation exhibit efficient migration despite incomplete segmentation of the nucleus","volume":"202","author":"van Grinsven","year":"2019","journal-title":"The Journal of Immunology"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1002\/path.5227","article-title":"Neutrophil trafficking to lymphoid tissues: physiological and pathological implications","volume":"247","author":"Voisin","year":"2019","journal-title":"The Journal of Pathology"},{"key":"bib49","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.139163","article-title":"ROS-producing immature neutrophils in giant cell arteritis are linked to vascular pathologies","volume":"5","author":"Wang","year":"2020","journal-title":"JCI Insight"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.4049\/jimmunol.1301721","article-title":"Aging and Cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans","volume":"192","author":"Wertheimer","year":"2014","journal-title":"The Journal of Immunology"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.immuni.2014.01.006","article-title":"Transcriptome-based network analysis reveals a spectrum model of human macrophage activation","volume":"40","author":"Xue","year":"2014","journal-title":"Immunity"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"3508","DOI":"10.4049\/jimmunol.1200662","article-title":"Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction","volume":"189","author":"Zizzo","year":"2012","journal-title":"The Journal of Immunology"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/66808\/elife-66808-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/66808\/elife-66808-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/66808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:12:01Z","timestamp":1697058721000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/66808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,22]]},"references-count":52,"alternative-id":["10.7554\/eLife.66808"],"URL":"https:\/\/doi.org\/10.7554\/elife.66808","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.09.21.306118","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2020.09.21.306118","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.66808.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.66808.sa2","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,22]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e66808"}}