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For example, in drug dependence, dysfunctional value-based decision-making and compulsive-like actions have been linked to hypo- and hyperactivity of orbital frontal cortex (OFC)-basal ganglia circuits, respectively; however, the underlying mechanisms are unknown. Here we show that alcohol-exposed mice have enhanced activity in OFC terminals in dorsal striatum (OFC-DS) associated with actions, but reduced activity of the same terminals during periods of outcome retrieval, corresponding with a loss of outcome control over decision-making. Disrupted OFC-DS terminal activity was due to a dysfunction of dopamine-type 1 receptors on spiny projection neurons (D1R SPNs) that resulted in increased retrograde endocannabinoid signaling at OFC-D1R SPN synapses reducing OFC-DS transmission. Blocking CB1 receptors restored OFC-DS activity in vivo and rescued outcome-based control over decision-making. These findings demonstrate a circuit-, synapse-, and computation-specific mechanism gating OFC activity in alcohol-exposed mice.<\/jats:p>","DOI":"10.7554\/elife.67065","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T09:00:14Z","timestamp":1615971614000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.67065","source":"Crossref","is-referenced-by-count":26,"title":["Mechanism for differential recruitment of orbitostriatal transmission during actions and outcomes following chronic alcohol exposure"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6199-0293","authenticated-orcid":true,"given":"Rafael","family":"Renteria","sequence":"first","affiliation":[{"name":"Department of Psychology, University of California San Diego, San Diego, United 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