{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:17:19Z","timestamp":1790878639933,"version":"4.1.0"},"reference-count":58,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37AI075039"],"award-info":[{"award-number":["R37AI075039"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI155634"],"award-info":[{"award-number":["R01AI155634"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","award":["Investigator Award"],"award-info":[{"award-number":["Investigator Award"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01AI066302"],"award-info":[{"award-number":["P01AI066302"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL134183"],"award-info":[{"award-number":["R01HL134183"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Type I interferons (IFNs) are essential for anti-viral immunity, but often impair protective immune responses during bacterial infections. An important question is how type I IFNs are strongly induced during viral infections, and yet are appropriately restrained during bacterial infections. The\n                    <jats:italic>Super susceptibility to tuberculosis 1<\/jats:italic>\n                    (\n                    <jats:italic>Sst1<\/jats:italic>\n                    ) locus in mice confers resistance to diverse bacterial infections. Here we provide evidence that\n                    <jats:italic>Sp140<\/jats:italic>\n                    is a gene encoded within the\n                    <jats:italic>Sst1<\/jats:italic>\n                    locus that represses type I IFN transcription during bacterial infections. We generated\n                    <jats:italic>Sp140<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice and found that they are susceptible to infection by\n                    <jats:italic>Legionella pneumophila<\/jats:italic>\n                    and\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    . Susceptibility of\n                    <jats:italic>Sp140<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice to bacterial infection was rescued by crosses to mice lacking the type I IFN receptor (\n                    <jats:italic>Ifnar<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    ). Our results implicate\n                    <jats:italic>Sp140<\/jats:italic>\n                    as an important negative regulator of type I IFNs that is essential for resistance to bacterial infections.\n                  <\/jats:p>","DOI":"10.7554\/elife.67290","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T08:00:28Z","timestamp":1624262428000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.67290","source":"Crossref","is-referenced-by-count":105,"title":["Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9148-3620","authenticated-orcid":true,"given":"Daisy X","family":"Ji","sequence":"first","affiliation":[{"name":"Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8744-9457","authenticated-orcid":true,"given":"Kristen C","family":"Witt","sequence":"additional","affiliation":[{"name":"Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-1503","authenticated-orcid":true,"given":"Dmitri I","family":"Kotov","sequence":"additional","affiliation":[{"name":"Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States"},{"name":"Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shally R","family":"Margolis","sequence":"additional","affiliation":[{"name":"Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Louie","sequence":"additional","affiliation":[{"name":"Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Chev\u00e9e","sequence":"additional","affiliation":[{"name":"Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine J","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States"},{"name":"Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz M","family":"Gaidt","sequence":"additional","affiliation":[{"name":"Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harmandeep S","family":"Dhaliwal","sequence":"additional","affiliation":[{"name":"Cancer Research Laboratory, University of California, Berkeley, Berkeley, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angus Y","family":"Lee","sequence":"additional","affiliation":[{"name":"Cancer Research Laboratory, University of California, Berkeley, Berkeley, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California, San Francisco, San Francisco, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7856-7512","authenticated-orcid":true,"given":"Dario S","family":"Zamboni","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6511-9246","authenticated-orcid":true,"given":"Igor","family":"Kramnik","sequence":"additional","affiliation":[{"name":"The National Emerging Infectious Diseases Laboratory, Department of Medicine (Pulmonary Center), and Department of Microbiology, Boston University School of Medicine, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A","family":"Portnoy","sequence":"additional","affiliation":[{"name":"Division of Immunology and Pathogenesis, 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