{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:18:54Z","timestamp":1792174734660,"version":"4.4.0"},"reference-count":70,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2018YFA0800801"],"award-info":[{"award-number":["2018YFA0800801"]}]},{"name":"National Key Research and Development Program of China","award":["2018YFA0800803"],"award-info":[{"award-number":["2018YFA0800803"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91749201"],"award-info":[{"award-number":["91749201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["81873679"],"award-info":[{"award-number":["81873679"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Disorders of the transparent cornea affect millions of people worldwide. However, how to maintain and\/or regenerate this organ remains unclear. Here, we show that\n                    <jats:italic>Rela<\/jats:italic>\n                    (encoding a canonical NF-\u03baB subunit) ablation in K14\n                    <jats:sup>+<\/jats:sup>\n                    corneal epithelial stem cells not only disrupts corneal regeneration but also results in age-dependent epithelial deterioration, which triggers aberrant wound-healing processes including stromal remodeling, neovascularization, epithelial metaplasia, and plaque formation at the central cornea. These anomalies are largely recapitulated in normal mice that age naturally. Mechanistically,\n                    <jats:italic>Rela<\/jats:italic>\n                    deletion suppresses expression of Aldh1a1, an enzyme required for retinoic acid synthesis from vitamin A. Retinoic acid administration blocks development of ocular anomalies in\n                    <jats:italic>\n                      Krt14-Cre; Rela\n                      <jats:sup>f\/f<\/jats:sup>\n                    <\/jats:italic>\n                    mice and naturally aged mice. Moreover, epithelial metaplasia and plaque formation are preventable by inhibition of angiogenesis. This study thus uncovers the major mechanisms governing corneal maintenance, regeneration, and aging and identifies the NF-\u03baB-retinoic acid pathway as a therapeutic target for corneal disorders.\n                  <\/jats:p>","DOI":"10.7554\/elife.67315","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T10:00:43Z","timestamp":1622800843000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.67315","source":"Crossref","is-referenced-by-count":26,"title":["Canonical NF-\u03baB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid"],"prefix":"10.7554","volume":"10","author":[{"given":"Qian","family":"Yu","sequence":"first","affiliation":[{"name":"Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 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