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Impairment of centrosomal nucleation in apical progenitors of the developing mouse brain induces p53-dependent apoptosis and causes non-lethal microcephaly. Whether disruption of non-centrosomal nucleation has similar effects is unclear. Here, we show, using mouse embryos, that conditional knockout of the augmin subunit\n                    <jats:italic>Haus6<\/jats:italic>\n                    in apical progenitors led to spindle defects and mitotic delay. This triggered massive apoptosis and abortion of brain development. Co-deletion of\n                    <jats:italic>Trp53<\/jats:italic>\n                    rescued cell death, but surviving progenitors failed to organize a pseudostratified epithelium, and brain development still failed. This could be explained by exacerbated mitotic errors and resulting chromosomal defects including increased DNA damage. Thus, in contrast to centrosomes, augmin is crucial for apical progenitor mitosis, and, even in the absence of p53, for progression of brain development.\n                  <\/jats:p>","DOI":"10.7554\/elife.67989","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T08:00:53Z","timestamp":1629792053000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.67989","source":"Crossref","is-referenced-by-count":21,"title":["Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8146-3693","authenticated-orcid":true,"given":"Ricardo","family":"Viais","sequence":"first","affiliation":[{"name":"Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, 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