{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:57:07Z","timestamp":1788245827162,"version":"build-2803163510"},"reference-count":43,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2018YFC1004200"],"award-info":[{"award-number":["2018YFC1004200"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2018YFA0107700"],"award-info":[{"award-number":["2018YFA0107700"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB19000000"],"award-info":[{"award-number":["XDB19000000"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["81525011"],"award-info":[{"award-number":["81525011"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970785"],"award-info":[{"award-number":["31970785"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31601193"],"award-info":[{"award-number":["31601193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671496"],"award-info":[{"award-number":["31671496"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2021,8,26]]},"abstract":"<jats:p>\n                    Protein arginine methyltransferase 5 (\n                    <jats:italic>Prmt5<\/jats:italic>\n                    ) is the major type II enzyme responsible for symmetric dimethylation of arginine. Here, we found that PRMT5 was expressed at high level in ovarian granulosa cells of growing follicles. Inactivation of\n                    <jats:italic>Prmt5<\/jats:italic>\n                    in granulosa cells resulted in aberrant follicle development and female infertility. In\n                    <jats:italic>Prmt5-<\/jats:italic>\n                    knockout mice, follicle development was arrested with disorganized granulosa cells in which WT1 expression was dramatically reduced and the expression of steroidogenesis-related genes was significantly increased. The premature differentiated granulosa cells were detached from oocytes and follicle structure was disrupted. Mechanism studies revealed that\n                    <jats:italic>Wt1<\/jats:italic>\n                    expression was regulated by PRMT5 at the protein level. PRMT5 facilitated IRES-dependent translation of\n                    <jats:italic>Wt1<\/jats:italic>\n                    mRNA by methylating HnRNPA1. Moreover, the upregulation of steroidogenic genes in\n                    <jats:italic>Prmt5<\/jats:italic>\n                    -deficient granulosa cells was repressed by\n                    <jats:italic>Wt1<\/jats:italic>\n                    overexpression. These results demonstrate that PRMT5 participates in granulosa cell lineage maintenance by inducing\n                    <jats:italic>Wt1<\/jats:italic>\n                    expression. Our study uncovers a new role of post-translational arginine methylation in granulosa cell differentiation and follicle development.\n                  <\/jats:p>","DOI":"10.7554\/elife.68930","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T08:01:58Z","timestamp":1630051318000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.68930","source":"Crossref","is-referenced-by-count":25,"title":["PRMT5 regulates ovarian follicle development by facilitating Wt1 translation"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5074-2174","authenticated-orcid":true,"given":"Min","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"Institute for Stem Cell and Regeneration, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine","place":["Beijing, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Dong","sequence":"first","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"Institute for Stem Cell and Regeneration, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6577-6705","authenticated-orcid":true,"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"Institute for Stem Cell and Regeneration, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowei","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"Institute for Stem Cell and Regeneration, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhuo","family":"Cen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"Institute for Stem Cell and Regeneration, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhong","family":"Cui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"Institute for Stem Cell and Regeneration, Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilai","family":"Bao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4029-6411","authenticated-orcid":true,"given":"Fei","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"Institute for Stem Cell and Regeneration, Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine","place":["Beijing, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1261\/rna.157806","article-title":"Searching for ires","volume":"12","author":"Baird","year":"2006","journal-title":"RNA"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"17098","DOI":"10.1074\/jbc.M110.109439","article-title":"Eif2alpha phosphorylation tips the balance to apoptosis during osmotic stress","volume":"285","author":"Bevilacqua","year":"2010","journal-title":"The Journal of Biological Chemistry"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/dvg.20231","article-title":"Development of a steroidogenic factor 1\/cre transgenic mouse line","volume":"44","author":"Bingham","year":"2006","journal-title":"Genesis"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"4144","DOI":"10.1074\/jbc.M411492200","article-title":"Heterogeneous nuclear ribonucleoprotein a1 is a novel internal ribosome entry site trans-acting factor that modulates alternative initiation of translation of the fibroblast growth factor 2 mrna","volume":"280","author":"Bonnal","year":"2005","journal-title":"The Journal of Biological Chemistry"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"5048","DOI":"10.1091\/mbc.e07-06-0603","article-title":"Cytoplasmic relocalization of heterogeneous nuclear ribonucleoprotein a1 controls translation initiation of specific mrnas","volume":"18","author":"Cammas","year":"2007","journal-title":"Molecular Biology of the Cell"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1093\/biolre\/ioaa042","article-title":"Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development\u2020","volume":"103","author":"Cen","year":"2020","journal-title":"Biology of Reproduction"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1242\/dev.144105","article-title":"WT1 directs the lineage specification of sertoli and granulosa cells by repressing sf1 expression","volume":"144","author":"Chen","year":"2017","journal-title":"Development"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/sj.onc.1203407","article-title":"Initiation of Apaf-1 translation by internal ribosome entry","volume":"19","author":"Coldwell","year":"2000","journal-title":"Oncogene"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1042\/BJ20120906","article-title":"HNRNP A1 mediates the activation of the ires-dependent SREBP-1A mrna translation in response to endoplasmic reticulum stress","volume":"449","author":"Damiano","year":"2013","journal-title":"The Biochemical Journal"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1016\/j.febslet.2010.11.010","article-title":"Histone arginine methylation","volume":"585","author":"Di Lorenzo","year":"2011","journal-title":"FEBS Lett"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1210\/jcem-70-4-1041","article-title":"Expression of messenger ribonucleic acid species encoding steroidogenic enzymes in human follicles and corpora lutea throughout the menstrual cycle","volume":"70","author":"Doody","year":"1990","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/nrm760","article-title":"Messenger-RNA-binding proteins and the messages they carry","volume":"3","author":"Dreyfuss","year":"2002","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"11987","DOI":"10.1073\/pnas.0600994103","article-title":"The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis","volume":"103","author":"Gao","year":"2006","journal-title":"PNAS"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1093\/hmg\/ddt423","article-title":"WT1 functions in ovarian follicle development by regulating granulosa cell differentiation","volume":"23","author":"Gao","year":"2014","journal-title":"Human Molecular Genetics"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"4359","DOI":"10.1093\/nar\/gkw1367","article-title":"PRMT5 regulates ires-dependent translation via methylation of Hnrnp A1","volume":"45","author":"Gao","year":"2017","journal-title":"Nucleic Acids Research"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040924","article-title":"IRES Trans-Acting Factors, Key Actors of the Stress Response","volume":"20","author":"Godet","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s11060-019-03274-0","article-title":"The protein arginine methyltransferase prmt5 confers therapeutic resistance to mtor inhibition in glioblastoma","volume":"145","author":"Holmes","year":"2019","journal-title":"Journal of Neuro-Oncology"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1210\/mend.9.10.8544844","article-title":"Wilms\u2019 tumor protein WT1 as an ovarian transcription factor: decreases in expression during follicle development and repression of inhibin-alpha gene promoter","volume":"9","author":"Hsu","year":"1995","journal-title":"Molecular Endocrinology"},{"key":"bib19","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-10-66","article-title":"Inactivation of Dicer1 in Steroidogenic factor 1-positive cells reveals tissue-specific requirement for Dicer1 in adrenal, testis, and ovary","volume":"10","author":"Huang","year":"2010","journal-title":"BMC Developmental Biology"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1210\/mend.7.7.8413309","article-title":"Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression","volume":"7","author":"Ikeda","year":"1993","journal-title":"Molecular Endocrinology"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.matbio.2004.05.008","article-title":"A novel basal lamina matrix of the stratified epithelium of the ovarian follicle","volume":"23","author":"Irving-Rodgers","year":"2004","journal-title":"Matrix Biology"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.mce.2011.07.049","article-title":"Oogenesis: Transcriptional regulators and mouse models","volume":"356","author":"Jagarlamudi","year":"2012","journal-title":"Molecular and Cellular Endocrinology"},{"key":"bib23","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11020142","article-title":"The perk branch of the unfolded protein response promotes dll4 expression by activating an alternative translation mechanism","volume":"11","author":"Jaud","year":"2019","journal-title":"Cancers"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"23274","DOI":"10.1074\/jbc.M801185200","article-title":"Heterogeneous nuclear ribonucleoprotein A1 regulates cyclin d1 and C-MYC internal ribosome entry site function through AKT signaling","volume":"283","author":"Jo","year":"2008","journal-title":"The Journal of Biological Chemistry"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.tibs.2011.09.001","article-title":"Versatility of prmt5-induced methylation in growth control and development","volume":"36","author":"Karkhanis","year":"2011","journal-title":"Trends in Biochemical Sciences"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.molcel.2014.10.003","article-title":"PRMT5 protects genomic integrity during global dna demethylation in primordial germ cells and preimplantation embryos","volume":"56","author":"Kim","year":"2014","journal-title":"Molecular Cell"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.bbagrm.2016.05.005","article-title":"SST2 translation is regulated by fgf2 via an HNRNP a1-mediated ires-dependent mechanism","volume":"1859","author":"Kunze","year":"2016","journal-title":"Biochimica et Biophysica Acta"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1091\/mbc.e06-06-0515","article-title":"Subcellular relocalization of a trans-acting factor regulates XIAP ires-dependent translation","volume":"18","author":"Lewis","year":"2007","journal-title":"Molecular Biology of the Cell"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"748","DOI":"10.15252\/embj.201489319","article-title":"The SM protein methyltransferase prmt5 is not required for primordial germ cell specification in mice","volume":"34","author":"Li","year":"2015","journal-title":"The EMBO Journal"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0070-2153(10)90007-0","article-title":"Building pathways for ovary organogenesis in the mouse embryo","volume":"90","author":"Liu","year":"2010","journal-title":"Current Topics in Developmental Biology"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.theriogenology.2016.04.017","article-title":"Driving folliculogenesis by the oocyte-somatic cell dialog: Lessons from genetic models","volume":"86","author":"Monniaux","year":"2016","journal-title":"Theriogenology"},{"key":"bib32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074710","article-title":"PRMT5 is upregulated in malignant and metastatic melanoma and regulates expression of MITF and p27(Kip1","volume":"8","author":"Nicholas","year":"2013","journal-title":"PLOS ONE"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1093\/humrep\/deq275","article-title":"Understanding follicle growth in vivo","volume":"25","author":"Oktem","year":"2010","journal-title":"Human Reproduction"},{"key":"bib34","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0021-9258(17)42223-X","article-title":"Enzymatic methylation of recombinant heterogeneous nuclear RNP protein A1. Dual substrate specificity for S-adenosylmethionine:histone-arginine N-methyltransferase","volume":"269","author":"Rajpurohit","year":"1994","journal-title":"The Journal of Biological Chemistry"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-3-642-02062-9_1","volume-title":"Handbook of Experimental Pharmacology","author":"Richards","year":"2010"},{"key":"bib36","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1431","article-title":"Emerging roles of HNRNPA1 in modulating malignant transformation","volume":"8","author":"Roy","year":"2017","journal-title":"Wiley Interdisciplinary Reviews RNA"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"10964","DOI":"10.1074\/jbc.M407874200","article-title":"Cyclin d1 and C-MYC internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 mapk- and erk-dependent pathway","volume":"280","author":"Shi","year":"2005","journal-title":"The Journal of Biological Chemistry"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"R145","DOI":"10.1530\/JOE-14-0062","article-title":"Development of mammalian ovary","volume":"221","author":"Smith","year":"2014","journal-title":"The Journal of Endocrinology"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.steroids.2008.01.017","article-title":"Aromatase expression in the ovary: hormonal and molecular regulation","volume":"73","author":"Stocco","year":"2008","journal-title":"Steroids"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"3200","DOI":"10.1038\/sj.onc.1207551","article-title":"Cellular internal ribosome entry segments: structures, trans-acting factors and regulation of gene expression","volume":"23","author":"Stoneley","year":"2004","journal-title":"Oncogene"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1007\/s00018-015-1847-9","article-title":"The PRMT5 arginine methyltransferase: Many roles in development, cancer and beyond","volume":"72","author":"Stopa","year":"2015","journal-title":"Cellular and Molecular Life Sciences"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.jmb.2016.12.011","article-title":"Methylarginines within the rgg-motif region of HNRNP A1 affect its IRES trans-acting factor activity and are required for HNRNP A1 stress granule localization and formation","volume":"429","author":"Wall","year":"2017","journal-title":"Journal of Molecular Biology"},{"key":"bib43","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.127308","article-title":"Protein arginine methyltransferase 5 (prmt5) is required for germ cell survival during mouse embryonic development","volume":"92","author":"Wang","year":"2015","journal-title":"Biology of Reproduction"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/68930\/elife-68930-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/68930\/elife-68930-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/68930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:17:29Z","timestamp":1697059049000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/68930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,27]]},"references-count":43,"alternative-id":["10.7554\/eLife.68930"],"URL":"https:\/\/doi.org\/10.7554\/elife.68930","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.04.04.438394","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2021.04.04.438394","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.68930.sa2","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.68930.sa1","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,27]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e68930"}}