{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:15:51Z","timestamp":1792660551839,"version":"4.5.0"},"reference-count":66,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL094414"],"award-info":[{"award-number":["R01HL094414"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL138577"],"award-info":[{"award-number":["R01HL138577"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM131845"],"award-info":[{"award-number":["GM131845"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL133286"],"award-info":[{"award-number":["R01HL133286"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2021,9,9]]},"abstract":"<jats:p>\n                    The Connexin43 gap junction gene\n                    <jats:italic>GJA1<\/jats:italic>\n                    has one coding exon, but its mRNA undergoes internal translation to generate N-terminal truncated isoforms of Connexin43 with the predominant isoform being only 20 kDa in size (GJA1-20k). Endogenous GJA1-20k protein is not membrane bound and has been found to increase in response to ischemic stress, localize to mitochondria, and mimic ischemic preconditioning protection in the heart. However, it is not known how GJA1-20k benefits mitochondria to provide this protection. Here, using human cells and mice, we identify that GJA1-20k polymerizes actin around mitochondria which induces focal constriction sites. Mitochondrial fission events occur within about 45 s of GJA1-20k recruitment of actin. Interestingly, GJA1-20k mediated fission is independent of canonical Dynamin-Related Protein 1 (DRP1). We find that GJA1-20k-induced smaller mitochondria have decreased reactive oxygen species (ROS) generation and, in hearts, provide potent protection against ischemia-reperfusion injury. The results indicate that stress responsive internally translated GJA1-20k stabilizes polymerized actin filaments to stimulate non-canonical mitochondrial fission which limits ischemic-reperfusion induced myocardial infarction.\n                  <\/jats:p>","DOI":"10.7554\/elife.69207","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T21:28:37Z","timestamp":1633382917000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.69207","source":"Crossref","is-referenced-by-count":40,"title":["Protective mitochondrial fission induced by stress-responsive protein GJA1-20k"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9954-2162","authenticated-orcid":true,"given":"Daisuke","family":"Shimura","sequence":"first","affiliation":[{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah","place":["Salt Lake City, United 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States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California at Los Angeles","place":["Los Angeles, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junco S","family":"Warren","sequence":"additional","affiliation":[{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah","place":["Salt Lake City, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A","family":"Palatinus","sequence":"additional","affiliation":[{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah","place":["Salt Lake City, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TingTing","family":"Hong","sequence":"additional","affiliation":[{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah","place":["Salt Lake City, United States"]},{"name":"Diabetes and Metabolism Research Center, University of Utah","place":["Salt Lake City, United States"]},{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah","place":["Salt Lake City, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2710-9765","authenticated-orcid":true,"given":"Jared","family":"Rutter","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of Utah","place":["Salt Lake City, United States"]},{"name":"Department of Biochemistry, University of Utah","place":["Salt Lake City, United States"]},{"name":"Diabetes and Metabolism Research Center, University of Utah","place":["Salt Lake City, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7429-6092","authenticated-orcid":true,"given":"Robin M","family":"Shaw","sequence":"additional","affiliation":[{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah","place":["Salt Lake City, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1002\/prot.24364","article-title":"Optimized E. coli expression strain LOBSTR eliminates common contaminants from His-tag purification","volume":"81","author":"Andersen","year":"2013","journal-title":"Proteins"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1093\/eurheartj\/ehu331","article-title":"Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results","volume":"36","author":"Atar","year":"2015","journal-title":"European Heart 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