{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:34:47Z","timestamp":1792499687559,"version":"4.5.0"},"reference-count":99,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2022,6,1]]},"abstract":"<jats:p>\n                    Sleep strongly affects synaptic strength, making it critical for cognition, especially learning and memory formation. Whether and\n                    <jats:italic>how<\/jats:italic>\n                    sleep deprivation modulates human brain physiology and cognition is not well understood. Here we examined how overnight sleep deprivation vs overnight sufficient sleep affects (a) cortical excitability, measured by transcranial magnetic stimulation, (b) inducibility of long-term potentiation (LTP)- and long-term depression (LTD)-like plasticity via transcranial direct current stimulation (tDCS), and (c) learning, memory, and attention. The results suggest that sleep deprivation upscales cortical excitability due to enhanced glutamate-related cortical facilitation and decreases and\/or reverses GABAergic cortical inhibition. Furthermore, tDCS-induced LTP-like plasticity (anodal) abolishes while the inhibitory LTD-like plasticity (cathodal) converts to excitatory LTP-like plasticity under sleep deprivation. This is associated with increased EEG theta oscillations due to sleep pressure. Finally, we show that learning and memory formation, behavioral counterparts of plasticity, and working memory and attention, which rely on cortical excitability, are impaired during sleep deprivation. Our data indicate that upscaled brain excitability and altered plasticity, due to sleep deprivation, are associated with impaired cognitive performance. Besides showing how brain physiology and cognition undergo changes (from neurophysiology to higher-order cognition) under sleep pressure, the findings have implications for\n                    <jats:italic>variability<\/jats:italic>\n                    and optimal\n                    <jats:italic>application<\/jats:italic>\n                    of noninvasive brain stimulation.\n                  <\/jats:p>","DOI":"10.7554\/elife.69308","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T08:00:51Z","timestamp":1654502451000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.69308","source":"Crossref","is-referenced-by-count":87,"title":["Sleep-dependent upscaled excitability, saturated neuroplasticity, and modulated cognition in the human brain"],"prefix":"10.7554","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1913-4677","authenticated-orcid":true,"given":"Mohammad Ali","family":"Salehinejad","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05cj29x94","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors","place":["Dortmund, Germany"]},{"id":[{"id":"https:\/\/ror.org\/04tsk2644","id-type":"ROR","asserted-by":"publisher"}],"name":"International Graduate School of Neuroscience, Ruhr-University Bochum","place":["Bochum, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5944-8123","authenticated-orcid":true,"given":"Elham","family":"Ghanavati","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05cj29x94","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors","place":["Dortmund, 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