{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:20:47Z","timestamp":1792002047820,"version":"4.4.0"},"reference-count":52,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["I-2061-20210327"],"award-info":[{"award-number":["I-2061-20210327"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG061338"],"award-info":[{"award-number":["R01AG061338"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RR150089"],"award-info":[{"award-number":["RR150089"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clayton Foundation for Research"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00AG042495"],"award-info":[{"award-number":["R00AG042495"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Concussion is associated with a myriad of deleterious immediate and long-term consequences. Yet the molecular mechanisms and genetic targets promoting the selective vulnerability of different neural subtypes to dysfunction and degeneration remain unclear. Translating experimental models of blunt force trauma in\n                    <jats:italic>C. elegans<\/jats:italic>\n                    to concussion in mice, we identify a conserved neuroprotective mechanism in which reduction of mitochondrial electron flux through complex IV suppresses trauma-induced degeneration of the highly vulnerable dopaminergic neurons. Reducing cytochrome C oxidase function elevates mitochondrial-derived reactive oxygen species, which signal through the cytosolic hypoxia inducing transcription factor,\n                    <jats:italic>Hif1a<\/jats:italic>\n                    , to promote hyperphosphorylation and inactivation of the pyruvate dehydrogenase, PDHE1\u03b1. This critical enzyme initiates the Warburg shunt, which drives energetic reallocation from mitochondrial respiration to astrocyte-mediated glycolysis in a neuroprotective manner. These studies demonstrate a conserved process in which glycolytic preconditioning suppresses Parkinson-like hypersensitivity of dopaminergic neurons to trauma-induced degeneration via redox signaling and the Warburg effect.\n                  <\/jats:p>","DOI":"10.7554\/elife.69438","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T12:00:41Z","timestamp":1630584041000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.69438","source":"Crossref","is-referenced-by-count":24,"title":["Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5927-5936","authenticated-orcid":true,"given":"Rene","family":"Solano Fonseca","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Metang","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Egge","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Texas at Dallas, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kielen R","family":"Zuurbier","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States"},{"name":"O\u2019Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthigayini","family":"Sivaprakasam","sequence":"additional","affiliation":[{"name":"O\u2019Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, United States"},{"name":"Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Shirazi","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology, University of California, Berkeley, Berkeley, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashleigh","family":"Chuah","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1123-3876","authenticated-orcid":true,"given":"Sonja LB","family":"Arneaud","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3363-7302","authenticated-orcid":true,"given":"Genevieve","family":"Konopka","sequence":"additional","affiliation":[{"name":"O\u2019Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, United States"},{"name":"Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Texas at Dallas, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0734-1049","authenticated-orcid":true,"given":"Peter M","family":"Douglas","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States"},{"name":"Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3171\/jns.1997.86.2.0241","article-title":"Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study","volume":"86","author":"Bergsneider","year":"1997","journal-title":"Journal of Neurosurgery"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2015.00091","article-title":"Oxidative stress and Parkinson's disease","volume":"9","author":"Blesa","year":"2015","journal-title":"Frontiers in Neuroanatomy"},{"key":"bib3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.15252\/embj.201695810","article-title":"Brain metabolism in health, aging, and\u00a0neurodegeneration","volume":"36","author":"Camandola","year":"2017","journal-title":"The EMBO Journal"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00112","article-title":"Glycolysis and the significance of lactate in traumatic brain injury","volume":"9","author":"Carpenter","year":"2015","journal-title":"Frontiers in Neuroscience"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1001\/jamaneurol.2016.1948","article-title":"Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings","volume":"73","author":"Crane","year":"2016","journal-title":"JAMA Neurology"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/hmg\/ddl477","article-title":"Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice","volume":"16","author":"Dell'agnello","year":"2007","journal-title":"Human Molecular Genetics"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.devcel.2019.11.001","article-title":"Age-onset phosphorylation of a minor actin variant promotes intestinal barrier dysfunction","volume":"51","author":"Egge","year":"2019","journal-title":"Developmental Cell"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21611-8","article-title":"Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress","volume":"12","author":"Egge","year":"2021","journal-title":"Nature Communications"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s10439-011-0394-2","article-title":"Viscoelastic properties of the rat brain in the sagittal plane: effects of anatomical structure and age","volume":"40","author":"Finan","year":"2012","journal-title":"Annals of Biomedical Engineering"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1016\/j.freeradbiomed.2012.09.035","article-title":"Mitochondrial morphology-emerging role in bioenergetics","volume":"53","author":"Galloway","year":"2012","journal-title":"Free Radical Biology and Medicine"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/j.1365-2990.1996.tb01126.x","article-title":"The spectrum of traumatic axonal injury","volume":"22","author":"Gennarelli","year":"1996","journal-title":"Neuropathology and Applied Neurobiology"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1089\/neu.2008.0857","article-title":"Early mitochondrial dysfunction after cortical contusion injury","volume":"26","author":"Gilmer","year":"2009","journal-title":"Journal of Neurotrauma"},{"key":"bib14","first-page":"51","volume-title":"Handbook of Clinical Neurology","author":"Giza","year":"2018"},{"key":"bib15","first-page":"228","article-title":"The neurometabolic cascade of concussion","volume":"36","author":"Giza","year":"2001","journal-title":"Journal of Athletic Training"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1089\/neu.2014.3483","article-title":"Lactate: brain fuel in human traumatic brain injury: a comparison with normal healthy control subjects","volume":"32","author":"Glenn","year":"2015","journal-title":"Journal of Neurotrauma"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.cmet.2005.05.001","article-title":"Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing","volume":"1","author":"Guzy","year":"2005","journal-title":"Cell Metabolism"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1089\/neu.2005.22.252","article-title":"Spatial and temporal characteristics of neurodegeneration after controlled cortical impact in mice: more than a focal brain injury","volume":"22","author":"Hall","year":"2005","journal-title":"Journal of Neurotrauma"},{"key":"bib19","first-page":"81","article-title":"Free radicals in CNS injury","volume":"71","author":"Hall","year":"1993","journal-title":"Research Publications - Association for Research in Nervous and Mental Disease"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/272976","article-title":"Characterization of closed head impact injury in rat","volume":"2015","author":"Hua","year":"2015","journal-title":"BioMed Research International"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1126\/science.1096485","article-title":"Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis","volume":"305","author":"Kasischke","year":"2004","journal-title":"Science"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1016\/j.cub.2015.06.062","article-title":"Mitochondrial Proteostatic Collapse Leads to Hypoxic Injury","volume":"25","author":"Kaufman","year":"2015","journal-title":"Current Biology"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.expneurol.2009.07.014","article-title":"Mechanical membrane injury induces axonal beading through localized activation of calpain","volume":"219","author":"Kilinc","year":"2009","journal-title":"Experimental Neurology"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.cmet.2006.02.002","article-title":"HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia","volume":"3","author":"Kim","year":"2006","journal-title":"Cell Metabolism"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1042\/bj3580069","article-title":"Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites","volume":"358","author":"Kolobova","year":"2001","journal-title":"Biochemical Journal"},{"key":"bib26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225774","article-title":"Pyruvate dehydrogenase and tricarboxylic acid cycle enzymes are sensitive targets of traumatic brain injury induced metabolic derangement","volume":"20","author":"Lazzarino","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1016\/j.cub.2010.10.057","article-title":"Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity","volume":"20","author":"Lee","year":"2010","journal-title":"Current Biology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1089\/neu.2015.4361","article-title":"Pioglitazone attenuates neuroinflammation and promotes dopaminergic neuronal survival in the nigrostriatal system of rats after diffuse brain injury","volume":"34","author":"Liu","year":"2017","journal-title":"Journal of Neurotrauma"},{"key":"bib29","doi-asserted-by":"publisher","DOI":"10.1038\/srep21569","article-title":"Mechanical characterization of the P56 mouse brain under large-deformation dynamic indentation","volume":"6","author":"MacManus","year":"2016","journal-title":"Scientific Reports"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.actbio.2016.10.029","article-title":"A viscoelastic analysis of the P56 mouse brain under large-deformation dynamic indentation","volume":"48","author":"MacManus","year":"2017","journal-title":"Acta Biomaterialia"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1126\/science.283.5401.496","article-title":"Energy on demand","volume":"283","author":"Magistretti","year":"1999","journal-title":"Science"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1136\/jnnp.2006.099796","article-title":"Acute metabolic brain changes following traumatic brain injury and their relevance to clinical severity and outcome","volume":"78","author":"Marino","year":"2007","journal-title":"Journal of Neurology, Neurosurgery & Psychiatry"},{"key":"bib33","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00043","article-title":"Lactate Shuttles in Neuroenergetics-Homeostasis, Allostasis and Beyond","volume":"11","author":"Mason","year":"2017","journal-title":"Frontiers in Neuroscience"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/bpa.12248","article-title":"The neuropathology of chronic traumatic encephalopathy","volume":"25","author":"McKee","year":"2015","journal-title":"Brain Pathology"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"3264","DOI":"10.1073\/pnas.042497999","article-title":"Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans","volume":"99","author":"Nass","year":"2002","journal-title":"PNAS"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1042\/BST0340217","article-title":"Regulation of the pyruvate dehydrogenase complex","volume":"34","author":"Patel","year":"2006","journal-title":"Biochemical Society Transactions"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"10625","DOI":"10.1073\/pnas.91.22.10625","article-title":"Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization","volume":"91","author":"Pellerin","year":"1994","journal-title":"PNAS"},{"key":"bib38","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009332","article-title":"Mitochondrial biology and Parkinson's disease","volume":"2","author":"Perier","year":"2012","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1042\/BJ20140291","article-title":"Complex IV-deficient Surf1(-\/-) mice initiate mitochondrial stress responses","volume":"462","author":"Pulliam","year":"2014","journal-title":"Biochemical Journal"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1101\/gr.2505604","article-title":"Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library","volume":"14","author":"Rual","year":"2004","journal-title":"Genome Research"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1111\/j.1471-4159.1977.tb10649.x","article-title":"The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat","volume":"28","author":"Sokoloff","year":"1977","journal-title":"Journal of Neurochemistry"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/0167-4838(84)90031-1","article-title":"Size and stability to sodium dodecyl sulfate of alkaline phosphatases from their three established human genes","volume":"790","author":"Stinson","year":"1984","journal-title":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of Single-Cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.nbd.2012.10.011","article-title":"Mitochondrial dysfunction and oxidative stress in Parkinson's disease","volume":"107","author":"Subramaniam","year":"2013","journal-title":"Progress in Neurobiology"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/jcbfm.2012.193","article-title":"Hypoxia-inducible factor 1 is essential for spontaneous recovery from traumatic brain injury and is a key mediator of heat acclimation induced neuroprotection","volume":"33","author":"Umschweif","year":"2013","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1007\/s10439-019-02277-2","article-title":"A 3-D Rat Brain Model for Blast-Wave Exposure: Effects of Brain Vasculature and Material Properties","volume":"47","author":"Unnikrishnan","year":"2019","journal-title":"Annals of Biomedical Engineering"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1098\/rstb.1986.0056","article-title":"The structure of the nervous system of the nematode Caenorhabditis elegans","volume":"314","author":"White","year":"1986","journal-title":"Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.redox.2014.01.019","article-title":"Optogenetic control of ROS production","volume":"2","author":"Wojtovich","year":"2014","journal-title":"Redox Biology"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.neulet.2009.01.047","article-title":"Traumatic brain injury-induced expression and phosphorylation of pyruvate dehydrogenase: a mechanism of dysregulated glucose metabolism","volume":"454","author":"Xing","year":"2009","journal-title":"Neuroscience Letters"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1089\/neu.1997.14.23","article-title":"Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury","volume":"14","author":"Xiong","year":"1997","journal-title":"Journal of Neurotrauma"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/0006-8993(91)90755-K","article-title":"Dynamic changes in local cerebral glucose utilization following cerebral conclusion in rats: evidence of a hyper- and subsequent hypometabolic state","volume":"561","author":"Yoshino","year":"1991","journal-title":"Brain Research"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/69438\/elife-69438-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/69438\/elife-69438-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/69438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:18:37Z","timestamp":1697059117000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/69438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,2]]},"references-count":52,"alternative-id":["10.7554\/eLife.69438"],"URL":"https:\/\/doi.org\/10.7554\/elife.69438","archive":["CLOCKSS"],"relation":{"is-supplemented-by":[{"id-type":"accession","id":"GSE173431","asserted-by":"subject"},{"id-type":"accession","id":"GSE179905","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.69438.sa2","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.69438.sa1","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,2]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e69438"}}