{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:22:25Z","timestamp":1785806545361,"version":"3.56.0"},"reference-count":45,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["725970"],"award-info":[{"award-number":["725970"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Objects can be recognized based on their intrinsic features, including shape, color, and texture. In daily life, however, such features are often not clearly visible, for example when objects appear in the periphery, in clutter, or at a distance. Interestingly, object recognition can still be highly accurate under these conditions when objects are seen within their typical scene context. What are the neural mechanisms of context-based object recognition? According to parallel processing accounts, context-based object recognition is supported by the parallel processing of object and scene information in separate pathways. Output of these pathways is then combined in downstream regions, leading to contextual benefits in object recognition. Alternatively, according to feedback accounts, context-based object recognition is supported by (direct or indirect) feedback from scene-selective to object-selective regions. Here, in three pre-registered transcranial magnetic stimulation (TMS) experiments, we tested a key prediction of the feedback hypothesis: that scene-selective cortex causally and selectively supports context-based object recognition before object-selective cortex does. Early visual cortex (EVC), object-selective lateral occipital cortex (LOC), and scene-selective occipital place area (OPA) were stimulated at three time points relative to stimulus onset while participants categorized degraded objects in scenes and intact objects in isolation, in different trials. Results confirmed our predictions: relative to isolated object recognition, context-based object recognition was selectively and causally supported by OPA at 160\u2013200 ms after onset, followed by LOC at 260\u2013300 ms after onset. These results indicate that context-based expectations facilitate object recognition by disambiguating object representations in the visual cortex.<\/jats:p>","DOI":"10.7554\/elife.69736","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T04:00:44Z","timestamp":1628568044000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.69736","source":"Crossref","is-referenced-by-count":36,"title":["Causal neural mechanisms of context-based object recognition"],"prefix":"10.7554","volume":"10","author":[{"given":"Miles","family":"Wischnewski","sequence":"first","affiliation":[{"name":"Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands"},{"name":"Department of Biomedical Engineering, University of Minnesota, Minneapolis, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4026-7303","authenticated-orcid":true,"given":"Marius 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