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We found support for this hypothesis by recording sleep-wake state alongside PER2 bioluminescence in freely behaving mice, demonstrating that PER2 bioluminescence increases during spontaneous waking and decreases during sleep. The temporary reinstatement of PER2-bioluminescence rhythmicity in behaviorally arrhythmic SCN-lesioned mice submitted to daily recurring sleep deprivations substantiates our hypothesis. Mathematical modeling revealed that PER2 dynamics can be described by a damped harmonic oscillator driven by two forces: a sleep-wake-dependent force and an SCN-independent circadian force. Our work underscores the notion that in peripheral tissues the clock gene circuitry integrates sleep-wake information and could thereby contribute to behavioral adaptability to respond to homeostatic requirements.\n                  <\/jats:p>","DOI":"10.7554\/elife.69773","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T08:00:25Z","timestamp":1639382425000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.69773","source":"Crossref","is-referenced-by-count":30,"title":["The sleep-wake distribution contributes to the peripheral rhythms in PERIOD-2"],"prefix":"10.7554","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0723-2026","authenticated-orcid":true,"given":"Marieke MB","family":"Hoekstra","sequence":"first","affiliation":[{"name":"Center for Integrative Genomics, University of Lausanne","place":["Lausanne, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6483-7430","authenticated-orcid":true,"given":"Maxime","family":"Jan","sequence":"first","affiliation":[{"name":"Center for Integrative Genomics, University of Lausanne","place":["Lausanne, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Katsioudi","sequence":"additional","affiliation":[{"name":"Center for Integrative Genomics, University of Lausanne","place":["Lausanne, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yann","family":"Emmenegger","sequence":"additional","affiliation":[{"name":"Center for Integrative Genomics, University of Lausanne","place":["Lausanne, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2500-2921","authenticated-orcid":true,"given":"Paul","family":"Franken","sequence":"additional","affiliation":[{"name":"Center for Integrative Genomics, University of Lausanne","place":["Lausanne, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4374","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/s0960-9822(02)00759-5","article-title":"Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus","volume":"12","author":"Akhtar","year":"2002","journal-title":"Current Biology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0010-406x(68)90324-1","article-title":"Temporal secretory responses of cultured hamster adrenals","volume":"26","author":"Andrews","year":"1968","journal-title":"Comparative Biochemistry and Physiology"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.neuroscience.2017.03.002","article-title":"Circadian rhythms of hedonic drinking behavior in mice","volume":"349","author":"Bainier","year":"2017","journal-title":"Neuroscience"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"R827","DOI":"10.1152\/ajpregu.00093.2005","article-title":"Persistence of sleep-temperature coupling after suprachiasmatic nuclei lesions in rats","volume":"289","author":"Baker","year":"2005","journal-title":"American Journal of Physiology. 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