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The determinants of feeding responses to stress are unknown, in part because this issue is rarely studied in rodents. We focused our efforts on the novelty-suppressed feeding (NSF) assay, which uses latency to eat as readout of anxiety-like behavior, but rarely assesses feeding per se. We explored how key variables in experimental paradigms \u2013 estrous and diurnal cyclicity, age and duration of social isolation, prandial state, diet palatability, and elevated body weight \u2013 influence stress-induced anxiety-like behavior and food intake in male and female C57BL\/6J mice. Latency to eat in the novel environment is increased in both sexes across most of the conditions tested, while effects on caloric intake are variable. In the common NSF assay (i.e., lean mice in the light cycle), sex-specific effects of the length of social isolation, and not estrous cyclicity, are the main source of variability. Under conditions that are more physiologically relevant for humans (i.e., overweight mice in the active phase), the novel stress now elicits robust hyperphagia in both sexes . This novel model of stress eating can be used to identify underlying neuroendocrine and neuronal substrates. Moreover, these studies can serve as a framework to integrate cross-disciplinary studies of anxiety and feeding related behaviors in rodents.<\/jats:p>","DOI":"10.7554\/elife.70271","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T08:16:05Z","timestamp":1640160965000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.70271","source":"Crossref","is-referenced-by-count":79,"title":["Assessing the effects of stress on feeding behaviors in laboratory mice"],"prefix":"10.7554","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0418-6282","authenticated-orcid":true,"given":"Marie","family":"Francois","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Naomi Berrie Diabetes Center, Division of Molecular Genetics, Columbia University Irving Medical Center","place":["New York, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Canal Delgado","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Naomi Berrie Diabetes Center, Division of Molecular Genetics, Columbia University Irving Medical Center","place":["New York, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9705-2645","authenticated-orcid":true,"given":"Nikolay","family":"Shargorodsky","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Naomi Berrie Diabetes Center, Division of Molecular Genetics, Columbia University Irving Medical Center","place":["New York, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Shiun","family":"Leu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Naomi Berrie Diabetes Center, Division of Molecular Genetics, Columbia University Irving Medical Center","place":["New York, United States"]},{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biostatistics, Columbia University Irving Medical Center","place":["New York, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4330-6240","authenticated-orcid":true,"given":"Lori","family":"Zeltser","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Naomi Berrie Diabetes Center, Division of Molecular Genetics, Columbia University Irving Medical Center","place":["New York, United States"]},{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center","place":["New York, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.yfrne.2014.05.004","article-title":"Sex differences in anxiety and depression clinical perspectives","volume":"35","author":"Altemus","year":"2014","journal-title":"Frontiers in Neuroendocrinology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/0006-8993(76)90890-8","article-title":"Stress related recovery from lateral hypothalamic aphagia","volume":"102","author":"Antelman","year":"1976","journal-title":"Brain Research"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"R1215","DOI":"10.1152\/ajpregu.00446.2012","article-title":"Sex differences in the physiology of eating","volume":"305","author":"Asarian","year":"2013","journal-title":"American Journal of Physiology. 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