{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:37:15Z","timestamp":1789763835526,"version":"4.0.1"},"reference-count":40,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:00:00Z","timestamp":1653350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:00:00Z","timestamp":1653350400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:00:00Z","timestamp":1653350400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K08AR077100"],"award-info":[{"award-number":["K08AR077100"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K23AR075898"],"award-info":[{"award-number":["K23AR075898"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015629","name":"Jerome L. Greene Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015629","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 GM 129342"],"award-info":[{"award-number":["R01 GM 129342"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR069572"],"award-info":[{"award-number":["AR069572"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 DE12354"],"award-info":[{"award-number":["R01 DE12354"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2022,4,17]]},"abstract":"<jats:sec id=\"abs1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Nucleic acid binding proteins are frequently targeted as autoantigens in systemic lupus erythematosus (SLE) and other interferon (IFN)-linked rheumatic diseases. The AIM-like receptors (ALRs) are IFN-inducible innate sensors that form supramolecular assemblies along double-stranded (ds)DNA of various origins. Here, we investigate the ALR absent in melanoma 2 (AIM2) as a novel autoantigen in SLE, with similar properties to the established ALR autoantigen interferon-inducible protein 16 (IFI16). We examined neutrophil extracellular traps (NETs) as DNA scaffolds on which these antigens might interact in a pro-immune context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>AIM2 autoantibodies were measured by immunoprecipitation in SLE and control subjects. Neutrophil extracellular traps were induced in control neutrophils and combined with purified ALR proteins in immunofluorescence and DNase protection assays. SLE renal tissues were examined for ALR-containing NETs by confocal microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>AIM2 autoantibodies were detected in 41\/131 (31.3%) SLE patients and 2\/49 (4.1%) controls. Our SLE cohort revealed a frequent co-occurrence of anti-AIM2, anti-IFI16, and anti-DNA antibodies, and higher clinical measures of disease activity in patients positive for antibodies against these ALRs. We found that both ALRs bind NETs in vitro and in SLE renal tissues. We demonstrate that ALR binding causes NETs to resist degradation by DNase I, suggesting a mechanism whereby extracellular ALR-NET interactions may promote sustained IFN signaling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our work suggests that extracellular ALRs bind NETs, leading to DNase resistant nucleoprotein fibers that are targeted as autoantigens in SLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs5\">\n                    <jats:title>Funding:<\/jats:title>\n                    <jats:p>These studies were funded by NIH R01 DE12354 (AR), P30 AR070254, R01 GM 129342 (JS), K23AR075898 (CM), K08AR077100 (BA), the Jerome L. Greene Foundation and the Rheumatology Research Foundation. Dr. Antiochos and Dr. Mecoli are Jerome L. Greene Scholars. The Hopkins Lupus Cohort is supported by NIH grant R01 AR069572. Confocal imaging performed at the Johns Hopkins Microscopy Facility was supported by NIH Grant S10 OD016374.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7554\/elife.72103","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T09:15:25Z","timestamp":1650359725000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.72103","source":"Crossref","is-referenced-by-count":57,"title":["The DNA sensors AIM2 and IFI16 are SLE autoantigens that bind neutrophil extracellular traps"],"prefix":"10.7554","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6166-9750","authenticated-orcid":true,"given":"Brendan","family":"Antiochos","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Johns Hopkins University School of Medicine, Division of Rheumatology","place":["Baltimore, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Trejo-Zambrano","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Johns Hopkins University School of Medicine, Division of Rheumatology","place":["Baltimore, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paride","family":"Fenaroli","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02k7wn190","id-type":"ROR","asserted-by":"publisher"}],"name":"Nephrology Unit, Parma University Hospital, Department of Medicine and Surgery","place":["Parma, Italy"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Johns Hopkins University School of Medicine, Division of Pathology","place":["Baltimore, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avi","family":"Rosenberg","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Johns Hopkins University School of Medicine, Division of Pathology","place":["Baltimore, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Baer","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Johns Hopkins University School of Medicine, Division of Rheumatology","place":["Baltimore, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archit","family":"Garg","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Johns Hopkins University School of Medicine, Department of Biophysics and Biophysical Chemistry","place":["Baltimore, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9570-2544","authenticated-orcid":true,"given":"Jungsan","family":"Sohn","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Johns Hopkins University School of Medicine, Division of Rheumatology","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Johns Hopkins University School of Medicine, Department of Biophysics and Biophysical Chemistry","place":["Baltimore, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Johns Hopkins University School of Medicine, Division of Rheumatology","place":["Baltimore, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Petri","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Johns Hopkins University School of Medicine, Division of Rheumatology","place":["Baltimore, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W","family":"Goldman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Johns Hopkins University School of Medicine, Division of Rheumatology","place":["Baltimore, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Mecoli","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Johns Hopkins University School of Medicine, Division of Rheumatology","place":["Baltimore, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4172-1539","authenticated-orcid":true,"given":"Livia","family":"Casciola-Rosen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Johns Hopkins University School of Medicine, Division of Rheumatology","place":["Baltimore, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony","family":"Rosen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Johns Hopkins University School of Medicine, Division of Rheumatology","place":["Baltimore, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Johns Hopkins University School of Medicine, Division of Pathology","place":["Baltimore, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2022,5,24]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.120179","article-title":"IFI16 filament formation in salivary epithelial cells shapes the anti-IFI16 immune response in Sj\u00f6gren\u2019s syndrome","volume":"3","author":"Antiochos","year":"2018","journal-title":"JCI Insight"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/bfz387","article-title":"Autoantibodies targeting LINE-1-encoded ORF1p are associated with systemic lupus erythematosus diagnosis but not disease activity","volume":"1","author":"Antiochos","year":"2021","journal-title":"Clinical and Experimental Rheumatology"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aax7942","article-title":"The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps","volume":"14","author":"Apel","year":"2021","journal-title":"Science Signaling"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/acr.22632","article-title":"Association of Antibodies to Interferon-Inducible Protein-16 With Markers of More Severe Disease in Primary Sj\u00f6gren\u2019s Syndrome","volume":"68","author":"Baer","year":"2016","journal-title":"Arthritis Care & Research"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1089\/jir.2014.0168","article-title":"The Extracellular IFI16 Protein Propagates Inflammation in Endothelial Cells Via p38 MAPK and NF-\u03baB p65 Activation","volume":"35","author":"Bawadekar","year":"2015","journal-title":"Journal of Interferon & Cytokine Research"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science (New York, N.Y.)"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-44379-w","article-title":"Neutrophil Extracellular Traps protein composition is specific for patients with Lupus nephritis and includes methyl-oxidized \u03b1enolase (methionine sulfoxide 93","volume":"9","author":"Bruschi","year":"2019","journal-title":"Scientific Reports"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/j.1365-2133.2010.10097.x","article-title":"Redistribution of the nuclear protein IFI16 into the cytoplasm of ultraviolet B-exposed keratinocytes as a mechanism of autoantigen processing","volume":"164","author":"Costa","year":"2011","journal-title":"The British Journal of Dermatology"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41423-018-0024-0","article-title":"NETosis, complement, and coagulation: a triangular relationship","volume":"16","author":"de Bont","year":"2019","journal-title":"Cellular & Molecular Immunology"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1136\/annrheumdis-2018-213181","article-title":"REDD1\/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A","volume":"78","author":"Frangou","year":"2019","journal-title":"Annals of the Rheumatic Diseases"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/ni.2913","article-title":"The adaptor ASC has extracellular and \u201cprionoid\u201d activities that propagate inflammation","volume":"15","author":"Franklin","year":"2014","journal-title":"Nature Immunology"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001201","article-title":"Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus","volume":"3","author":"Garcia-Romo","year":"2011","journal-title":"Science Translational Medicine"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"v39","DOI":"10.1093\/rheumatology\/keaa381","article-title":"Lupus nephritis: clinical presentations and outcomes in the 21st century","volume":"59","author":"Gasparotto","year":"2020","journal-title":"Rheumatology (Oxford, England)"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"3364","DOI":"10.4049\/jimmunol.1700778","article-title":"Netting Neutrophils Activate Autoreactive B Cells in Lupus","volume":"200","author":"Gestermann","year":"2018","journal-title":"Journal of Immunology (Baltimore, Md)"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063045","article-title":"Nuclear DNA sensor IFI16 as circulating protein in autoimmune diseases is a signal of damage that impairs endothelial cells through high-affinity membrane binding","volume":"8","author":"Gugliesi","year":"2013","journal-title":"PLOS ONE"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/nrneph.2016.71","article-title":"The role of neutrophils and NETosis in autoimmune and renal diseases","volume":"12","author":"Gupta","year":"2016","journal-title":"Nature Reviews. Nephrology"},{"key":"bib17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI144918","article-title":"Bite of the wolf: innate immune responses propagate autoimmunity in lupus","volume":"131","author":"Gupta","year":"2021","journal-title":"The Journal of Clinical Investigation"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"9813","DOI":"10.1073\/pnas.0909927107","article-title":"Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis","volume":"107","author":"Hakkim","year":"2010","journal-title":"PNAS"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/nature07725","article-title":"AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC","volume":"458","author":"Hornung","year":"2009","journal-title":"Nature"},{"key":"bib20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008811","article-title":"Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding","volume":"16","author":"Iannucci","year":"2020","journal-title":"PLOS Pathogens"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nm.1959","article-title":"Netting neutrophils in autoimmune small-vessel vasculitis","volume":"15","author":"Kessenbrock","year":"2009","journal-title":"Nature Medicine"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1016\/j.autrev.2017.09.012","article-title":"Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review","volume":"16","author":"Lee","year":"2017","journal-title":"Autoimmunity Reviews"},{"key":"bib23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00035","article-title":"Clearance Deficiency and Cell Death Pathways: A Model for the Pathogenesis of SLE","volume":"7","author":"Mahajan","year":"2016","journal-title":"Frontiers in Immunology"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.autrev.2008.02.002","article-title":"DNase 1 and systemic lupus erythematosus","volume":"7","author":"Mart\u00ednez Valle","year":"2008","journal-title":"Autoimmunity Reviews"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"E1963","DOI":"10.1073\/pnas.1712860115","article-title":"Digital signaling network drives the assembly of the AIM2-ASC inflammasome","volume":"115","author":"Matyszewski","year":"2018","journal-title":"PNAS"},{"key":"bib26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23045-8","article-title":"Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome","volume":"12","author":"Matyszewski","year":"2021","journal-title":"Nature Communications"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1172\/JCI23025","article-title":"Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9","volume":"115","author":"Means","year":"2005","journal-title":"The Journal of Clinical Investigation"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.clim.2016.08.010","article-title":"Cell death in the pathogenesis of systemic lupus erythematosus and lupus nephritis","volume":"185","author":"Mistry","year":"2017","journal-title":"Clinical Immunology (Orlando, Fla.)"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"E62","DOI":"10.1073\/pnas.1313577111","article-title":"Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy","volume":"111","author":"Morrone","year":"2014","journal-title":"PNAS"},{"key":"bib30","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8827","article-title":"Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC","volume":"6","author":"Morrone","year":"2015","journal-title":"Nature Communications"},{"key":"bib31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01028","article-title":"Sources of Pathogenic Nucleic Acids in Systemic Lupus Erythematosus","volume":"10","author":"Mustelin","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1002\/art.34473","article-title":"Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus","volume":"64","author":"Petri","year":"2012","journal-title":"Arthritis and Rheumatism"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1146\/annurev-immunol-032414-112205","article-title":"Autoantigens as Partners in Initiation and Propagation of Autoimmune Rheumatic Diseases","volume":"34","author":"Rosen","year":"2016","journal-title":"Annual Review of Immunology"},{"key":"bib34","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55080431","article-title":"Neutrophil Extracellular Traps in the Establishment and Progression of Renal Diseases","volume":"55","author":"Salazar-Gonzalez","year":"2019","journal-title":"Medicina (Kaunas, Lithuania)"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/art.39859","article-title":"2016 American College of Rheumatology\/European League Against Rheumatism Classification Criteria for Primary Sj\u00f6gren\u2019s Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts","volume":"69","author":"Shiboski","year":"2017","journal-title":"Arthritis & Rheumatology (Hoboken, N.J.)"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"5191","DOI":"10.1038\/s41388-018-0339-4","article-title":"Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense","volume":"37","author":"So","year":"2018","journal-title":"Oncogene"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1038\/ni.1932","article-title":"IFI16 is an innate immune sensor for intracellular DNA","volume":"11","author":"Unterholzner","year":"2010","journal-title":"Nature Immunology"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/art.37720","article-title":"The rheumatoid arthritis synovial fluid citrullinome reveals novel citrullinated epitopes in apolipoprotein E, myeloid nuclear differentiation antigen, and \u03b2-actin","volume":"65","author":"van Beers","year":"2013","journal-title":"Arthritis and Rheumatism"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"538","DOI":"10.4049\/jimmunol.1100450","article-title":"Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus","volume":"187","author":"Villanueva","year":"2011","journal-title":"Journal of Immunology (Baltimore, Md)"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.autrev.2012.10.006","article-title":"Type I interferons in Sj\u00f6gren\u2019s syndrome","volume":"12","author":"Yao","year":"2013","journal-title":"Autoimmunity Reviews"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/72103\/elife-72103-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/72103\/elife-72103-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/72103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:06:22Z","timestamp":1697058382000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/72103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,24]]},"references-count":40,"alternative-id":["10.7554\/eLife.72103"],"URL":"https:\/\/doi.org\/10.7554\/elife.72103","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.08.19.456941","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2021.08.19.456941","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.72103.sa0","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.72103.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.72103.sa2","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,24]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e72103"}}