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A commensal bacterium,\n                    <jats:italic>Paracoccus aminovorans,<\/jats:italic>\n                    was previously identified in high abundance in stool collected from individuals infected with\n                    <jats:italic>V. cholerae<\/jats:italic>\n                    when compared to stool from uninfected persons. However, if and how\n                    <jats:italic>P. aminovorans<\/jats:italic>\n                    interacts with\n                    <jats:italic>V. cholerae<\/jats:italic>\n                    has not been experimentally determined; moreover, whether any association between this bacterium alters the behaviors of\n                    <jats:italic>V. cholerae<\/jats:italic>\n                    to affect the disease outcome is unclear. Here, we show that\n                    <jats:italic>P. aminovorans<\/jats:italic>\n                    and\n                    <jats:italic>V. cholerae<\/jats:italic>\n                    together form dual-species biofilm structure at the air\u2013liquid interface, with previously uncharacterized novel features. Importantly, the presence of\n                    <jats:italic>P. aminovorans<\/jats:italic>\n                    within the murine small intestine enhances\n                    <jats:italic>V. cholerae<\/jats:italic>\n                    colonization in the same niche that is dependent on the\n                    <jats:italic>Vibrio<\/jats:italic>\n                    exopolysaccharide and other major components of mature\n                    <jats:italic>V. cholerae<\/jats:italic>\n                    biofilm. These studies illustrate that multispecies biofilm formation is a plausible mechanism used by a gut microbe to increase the virulence of the pathogen, and this interaction may alter outcomes in enteric infections.\n                  <\/jats:p>","DOI":"10.7554\/elife.73010","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T08:00:22Z","timestamp":1648454422000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.73010","source":"Crossref","is-referenced-by-count":29,"title":["Impact of a human gut microbe on Vibrio cholerae host colonization through biofilm enhancement"],"prefix":"10.7554","volume":"11","author":[{"given":"Kelsey","family":"Barrasso","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05wvpxv85","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular Biology and Microbiology, Tufts University School of Medicine","place":["Boston, United 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